Quantitative Measurement of the Histamine‐releasing Activity of a Series of Mono‐alkyl‐amines Using Minced Guinea‐pig Lung

Mongar, J. L.; Schild, H. O.

doi:10.1111/j.1476-5381.1953.tb00760.x

Cited by 39 publications

(24 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is consistent, at least for histamine release, with the results of Mongar and Schild (10). It is also seen that all the agents do not elicit quantitatively the same reaction: 48/805 is more potent than morphine which is more active than octadecylarnine which in turn is more active than tween 20.…”

Section: Resultssupporting

confidence: 79%

Tissue Reactions to Anaphylactic and Anaphylactoid Stimuli; Proteolysis and Release of Histamine and Heparin

Ungar

Damgaard

1955

The Journal of Experimental Medicine

View full text Add to dashboard Cite

Addition of the specific antigen to slices of liver or lung taken from sensitized guinea pigs, or the addition of anaphylactoid agents (tween 20, octadecylamine, morphine, and 48/80) to tissue slices from normal animals, or the perfusion of lung with these agents, has been shown to cause protein breakdown and liberation of histamine and heparin. The dose correlation between these phenomena raises the question of which is the causal event. Suppression of histamine and heparin release by inhibition of proteolysis suggests that the latter is the more fundamental reaction, but the problem probably can not be decided on the basis of present knowledge. Tissue proteolysis induced by the agents investigated in this work results from the action of a protease present in normal tissues as an inactive precursor. Conversion of the proenzyme requires the intervention of a kinase. The tissue kinase seems to be different from the serum kinase which has been shown to be related to complement. Serum kinase, however, also acts on tissue proenzyme and probably plays an important role in tissue reactions as elicited in the intact animal.

show abstract

Section: Resultssupporting

confidence: 79%

Tissue Reactions to Anaphylactic and Anaphylactoid Stimuli; Proteolysis and Release of Histamine and Heparin

Ungar

Damgaard

1955

The Journal of Experimental Medicine

View full text Add to dashboard Cite

show abstract

“…A series of uniform samples were prepared as described by Mongar & Schild (1953) and incubated at 370 C in 10 ml. beakers for 15 min with 0-9 ml.…”

mentioning

confidence: 99%

Effect of antigen and octylamine on mast cells and histamine content of sensitized guinea‐pig tissues

Mota¹

1959

The Journal of Physiology

View full text Add to dashboard Cite

“…Histamine-releasing Activity.-The histaminereleasing activity of diamines has been demonstrated by MacIntosh and Paton (1949), by the test of the delayed fall in blood pressure in the cat anaesthetized with chloralose. The results reported have been obtained using minced guinea-pig lung (Mongar and Schild, 1953b), and isolated rat diaphragm (Rocha e Silva and Schild, 1949) to measure histamine-releasing activity of diamines of chain length C. to C15. solutions of straight-chain aliphatic diamines of various chain lengths.…”

Section: Resultsmentioning

confidence: 99%

“…This paper describes the influence of chainlength and pH on these properties. Part of the results have already been briefly described (Mongar and Schild, 1953a).…”

mentioning

confidence: 95%

Effect of Chain Length of Aliphatic Amines on Histamine Potentiation and Release

Mongar

1957

British Journal of Pharmacology and Chemotherapy

Self Cite

View full text Add to dashboard Cite

Diamines in the series NH2.(CH2)n.NH2 specifically potentiate histamine contractions of the guinea-pig ileum and inhibit the enzymatic destruction of histamine. These activities are greatest with short-chain compounds (n -5). Diamines also release histamine from isolated tissues and depress the contractility of plain muscle and the motility of paramecia. These activities increase with chain-length and are probably limited only by solubility. The parallelism between histaminereleasing activity and toxicity also extends to the monoamines in the series Cff3.(CH5)n-1.NH2.Histamine-releasing activity of both series increases with increase of pH and can mainly be attributed to the non-ionized base.From the results on the effect of chain-length and ionization on activity, it is suggested that aliphatic amines release histamine by penetration of the cell membrane in the non-ionized form, followed by exchange in the ionic form with intracellular histamine.Within the homologous series of monoamines

show abstract

Quantitative Measurement of the Histamine‐releasing Activity of a Series of Mono‐alkyl‐amines Using Minced Guinea‐pig Lung

Cited by 39 publications

References 11 publications

Tissue Reactions to Anaphylactic and Anaphylactoid Stimuli; Proteolysis and Release of Histamine and Heparin

Tissue Reactions to Anaphylactic and Anaphylactoid Stimuli; Proteolysis and Release of Histamine and Heparin

Effect of antigen and octylamine on mast cells and histamine content of sensitized guinea‐pig tissues

Effect of Chain Length of Aliphatic Amines on Histamine Potentiation and Release

Contact Info

Product

Resources

About