Quantitative Measurement of Thromboelastography as a Function of Platelet Count

Oshita, Kyoko; Azma, Toshiharu; Osawa, Yasuhiro; Yuge, Osafumi

doi:10.1097/00000539-199908000-00006

Cited by 33 publications

(25 citation statements)

References 6 publications

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“…1c, 2d vs. 2b). Such concept is also supported by our previous study by using TEG that the number of platelets is closely related to the strength of clot [18].…”

Section: Discussionsupporting

confidence: 73%

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Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood

Azma

Matsubara

Kinoshita

et al. 2008

J Thromb Thrombolysis

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A number of types of non-neuronal cells including leukocytes have been confirmed to possess substance-P and its specific neurokinin-1 receptor (NK1R), while the pathophysiological roles of substance-P in these cells remain to be established. Effects of substance-P through NK1R on platelet-dependent clot formation were evaluated by using an oscillating-probe viscoelastometer. The clot signal, indicative of the clot strength in blood-derived samples, was measured after the stimulation with celite and Ca(2+). Substance-P (10 nM) increased the clot signal of whole blood obtained from healthy volunteers, especially modulating the platelet-dependent distinctive peak in traces of the signal. A NK1R antagonist Spantide (500 nM) blocked such substance-P derived change, suggesting the involvement of platelets in the action of substance-P. In contrast, substance-P did not increase the clot signal of platelet-containing but leukocyte-removed plasma. From these, we conclude that substance-P promotes platelet-dependent clot formation through NK1R, in which leukocytes appear to be involved.

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“…1c, 2d vs. 2b). Such concept is also supported by our previous study by using TEG that the number of platelets is closely related to the strength of clot [18].…”

Section: Discussionsupporting

confidence: 73%

“…Recalcification of citrated blood-derived samples split from single container made us possible to perform controlled examination for the clot formation [17,18].…”

Section: Introductionmentioning

confidence: 99%

Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood

Azma

Matsubara

Kinoshita

et al. 2008

J Thromb Thrombolysis

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“…In contrast to other reports, however, the MCF (similar to the MA in TEGH) in our study series was not increased in patients with recent thrombosis as compared to healthy controls. Previously reported data indicate that the MCF correlates with the platelet count as well as activity [13]. It is well known that global tissue factor-driven plasma coagulation assays, employing a high concentration of tissue factor, are insensitive to hypercoagulation.…”

Section: Discussionmentioning

confidence: 97%

Whole blood thrombelastographic coagulation profiles using minimal tissue factor activation can display hypercoagulation in thrombosis‐prone patients

Poulsen

Christiansen

Sørensen

et al. 2006

Scandinavian Journal of Clinical and Laboratory Investigation

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“…Such a selection would be very helpful and would allow us to start an early and aggressive treatment, which aims at eliminating morbidity and mortality. Although there is an obvious trend in hematology to interpret qualitatively and quantitatively complicated coagulation profiles with additional methods [4,5,7,8], their exact role in HIT has not been investigated yet.…”

Section: Discussionmentioning

confidence: 99%

“…Several authors have studied the role of thromboelastography (TEG) to evaluate the effect of platelets and rFVIIa on the kinetics of clot formation and clot firmness [3][4][5]. Our purpose was to explore the potency of TEG to predict those HIT patients (5%) who are subject to develop thrombotic complications of type II.…”

Section: Introductionmentioning

confidence: 99%

Can thromboelastography predict which patients with heparin-induced thrombocytopenia may suffer thrombotic complications of type II?

Kouerinis

El-Ali

Theakos

et al. 2007

European Journal of Cardio-Thoracic Surgery

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Despite the existence of several sensitive functional and antigen assays used for the diagnosis of heparin-induced thrombocytopenia (HIT), an additional assessment of the patient's hemostatic status, in order to predict the thrombotic complications of the malevolent HIT type II, has become necessary. Herein below, we present the findings of thromboelastography (TEG) in a post-cardiac-surgery patient with the clinical diagnosis of HIT type II and false negative tests for heparin antibodies. We have reached the conclusion that TEG may prove to be a useful supplementary method to predict those HIT patients who may suffer complications of HIT type II.

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Quantitative Measurement of Thromboelastography as a Function of Platelet Count

Cited by 33 publications

References 6 publications

Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood

Prothrombotic roles of substance-P, neurokinin-1 receptors and leukocytes in the platelet-dependent clot formation in whole blood

Whole blood thrombelastographic coagulation profiles using minimal tissue factor activation can display hypercoagulation in thrombosis‐prone patients

Can thromboelastography predict which patients with heparin-induced thrombocytopenia may suffer thrombotic complications of type II?

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