Quantitative measurements of prostate capsule and gland density and their correlation to prostate size: possible clinical implications in prostate cancer

Weaver, Preston; Smith, Lisa A.; Keesari, Rohali; Mekdash, Hasan Al; Riese, Werner de

doi:10.1007/s11255-020-02527-6

Cited by 10 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As 80% of PCa originates from the glandular epithelium within the PZ this supports the hypothesis that these dynamic interactions between the growing TZ and compressed PZ explain the decreased incidence of PCa in large BPH prostates. 13,14 size prostates had a huge range of PZ thickness whereas large prostates with a total volume around 90 mL or above showed a noticeable drop in PZ thickness suggesting the PZ can resist pressure from the TZ growth to a certain point only. 15 This inverse relationship may also explain the results of the Prostate Cancer Prevention Trial, where almost 19,000 patients received continuous Finasteride medication.…”

Section: Discussionmentioning

confidence: 99%

Any Correlation Between Prostate Volume and Incidence of Prostate Cancer: A Review of Reported Data for the Last Thirty Years

Yamashiro¹,

Riese²

2021

RRU

View full text Add to dashboard Cite

Purpose: Prostate cancer (PCa) is the most common non-skin cancer in men worldwide and more than 80% of men with PCa also have histo-anatomical findings of benign prostate hyperplasia (BPH). It is well documented that BPH develops in the transition zone (TZ), whereas 80-85% of PCa originates in the peripheral zone (PZ) of the prostate. Possible causal links between both disease entities are controversially discussed in the current literature. Some studies have reported that larger prostates have a decreased incidence of PCa compared to smaller prostates. The purpose of this systematic review is to comprehensively summarize studies analyzing any association between prostate gland volume and incidence of PCa. Methods: A thorough literature review was performed between 01.01.1990 through 02.28.2020 using PubMed and applying the "PRISMA" guidelines. Inclusion and exclusion criteria were defined. Results: Our systematic review found 41 articles reporting an inverse (negative) relationship between prostate gland volume and incidence of prostate cancer. Sample sizes ranged from 114 to 6692 patients in these single institutional and multi-institutional studies. Thirty-nine (95%) of the 41 articles showed a statistically significant inverse relationship. In our search, no study was found showing a positive correlation between BPH size and the incidence of PCa. Conclusion: To our knowledge, this is the first systematic review on the important clinical question of interaction between prostate size and the incidence of PCa. The results are demonstrating an inverse relationship, and therefore reveal strong evidence that large prostates may be protective of PCa when compared to smaller prostates.

show abstract

Section: Discussionmentioning

confidence: 99%

Any Correlation Between Prostate Volume and Incidence of Prostate Cancer: A Review of Reported Data for the Last Thirty Years

Yamashiro¹,

Riese²

2021

RRU

View full text Add to dashboard Cite

show abstract

“…This pressure can result in glandular tissue atrophy and scarring in the peripheral zone, leading to the thickening of the prostate capsule. Histological studies have shown that the thickness of the prostate capsule, the atrophy of glands, and the scarring of glandular epithelial cells in the peripheral zone are positively associated with PV [24,25].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Transrectal Ultrasonography Guided Prostate Biopsy Gleason Score Results with Prostate Volume in Patients with Prostate Specific Antigen Level Between 2.5-10 ng/ml.

Bostancı,

Erdem

2024

Preprint

View full text Add to dashboard Cite

Purpose To investigate the correlation between prostate volume and Gleason score results obtained by systematic transrectal prostate biopsy in patients with a prostate-specific antigen value between 2,5–10 ng/ml. Methods 904 patients who underwent transrectal prostate biopsy at our institution were divided into four groups based on prostate volume calculated by transrectal ultrasonography. Group 1 had a prostate volume ≤ 35 cc, Group 2 had a prostate volume ranging from 36-55cc, Group 3 had a prostate volume between 56-75cc, and Group 4 had a prostate volume > 75cc. Subgroups were based on biopsy-proven prostate carcinoma patients within each group in the same prostate volume intervals, and the prostate cancer detection rates and Gleason scores were calculated for each group and subgroup. Results The prostate cancer detection rate was 78.5% in Group 1 and decreased to 17.2% in Group 4. Gleason score ≥ 8 also decreased from 16.4% in Group 1 to 2.5% in Group 4. However, there was no statistically significant difference between Gleason score ≥ 8 in subgroups, with the results of 20,9% in Group 1a and 15% in Group 4a. Conclusion Our study results suggest an inverse relationship between prostate volume, and cancer detection rates. Although Gleason score ≤ 6 rates in biopsy-proven prostate carcinoma patients increased, and Gleason score of 7 decreased in larger prostates it was not obvious in patients with Gleason score ≥ 8. Further prospective studies with large volumes of patients are required to confirm our analysis. Trial registration number and date of registration: 2023/1633 on 07/02/2024 retrospectively registered

show abstract

“…Как известно, локализованные образования ПЖ не имеют клинических проявлений [18]. Однако в нашем исследовании большинство больных имели выраженные обструктивные симптомы.…”

Section: Discussionunclassified

The importance of surgical access in the treatment of patients with prostate cancer and abnormal prostate anatomy

et al. 2022

View full text Add to dashboard Cite

Background. The increased volume of the prostate in patients with confirmed prostate cancer (pc) is observed in 10 % of cases. The limitations of external beam radiotherapy and brachytherapy associated with large prostate volume and obstructive symptoms define radical prostatectomy (Rp) as the only possible treatment for prostate cancer in these patients. The purpose of the study was to determine the importance of the surgical approach in radical prostatectomy in patients with abnormal anatomy of the prostate. Material and methods. The study group consisted of patients with a prostate volume of more than 80 cm3 (n=40) who underwent a robot prostatectomy. The comparison group was represented by patients also selected by the prostate volume ≥ 80 cm3, who underwent classical open prostatectomy (n=44). The groups were comparable in age and psa level. The average prostate volume in the study group was 112.2 ± 26 cm 3(80–195 cm 3). The average prostate volume in the comparison group was 109.8 ± 18.7 cm3 (80–158 cm 3) (р>0.05). Both groups had favorable morphological characteristics. Results. The average surgery time difference was 65 minutes in favor of the open prostatectomy (p<0.05). The average blood loss volume in the study group was 282.5 ± 227.5 ml (50–1000 ml). The average blood loss volume in the group with open prostatectomy was 505.7 ± 382.3 ml (50–2000 ml). Positive surgical margin in the robotic prostatectomy was not detected, at 6.9 % in the group with open prostatectomy (p<0.05). According to the criterion of urinary continence, the best results were obtained in the group of robotic prostatectomy (p<0.05). Overall and relapse-free 5-year survival did not show a statistically significant difference. Conclusion. The use of robotic prostatectomy in a group of patients with a large prostate volume (≥ 80 cm3) allows us to achieve better functional and oncological outcomes.

show abstract

Quantitative measurements of prostate capsule and gland density and their correlation to prostate size: possible clinical implications in prostate cancer

Cited by 10 publications

References 24 publications

Any Correlation Between Prostate Volume and Incidence of Prostate Cancer: A Review of Reported Data for the Last Thirty Years

Any Correlation Between Prostate Volume and Incidence of Prostate Cancer: A Review of Reported Data for the Last Thirty Years

Correlation of Transrectal Ultrasonography Guided Prostate Biopsy Gleason Score Results with Prostate Volume in Patients with Prostate Specific Antigen Level Between 2.5-10 ng/ml.

The importance of surgical access in the treatment of patients with prostate cancer and abnormal prostate anatomy

Contact Info

Product

Resources

About