Background: The interaction of workers and work tools does not always have a good impact; the mismatch of worker anthropometry and work tools impacts work-related diseases. Jobs with repetitive motions, manual lifting, and awkward postures cause complaints of CTDs. These complaints impact decreased productivity and, in the long run, cause permanent disability. This study aims to determine the risk factors for CTDs complaints. Material and methods: Analytical observational research with a quantitative approach and a cross-sectional design. The population in this study is production workers at an Indonesian spinning and dyeing factory company. The sampling technique used is Total Sampling. The dependent variable is Complaints of CTDs, with the independent variables namely work posture, gender, age, BMI, and years of service. The research instruments used were questionnaires and REBA. Univariable analysis to determine the frequency distribution and bivariable analysis with the chi-square test. Result: Work posture is at risk of experiencing CTDs complaints as much as 90.9%, female sex as much as 71.2%, old age 87.9%, BMI not at risk 56.1%, years of service ≥4 years is 95.5%, and there are very high CTDs complaints 66.7%. There is a relationship between work posture (p value=0.001) and years of service (p value=0.003) with CTD complaints. There was no relationship between gender (p value=0.393), age (p value=0.960), and BMI 0.429) with complaints of CTDs. Conclusion: Most workers experience complaints of CTDs. The risk factors for CTDs revealed in this study are work posture and length of service.