Quantitative MRI Analysis of the Brain after Twenty-Two Years of Neuromyelitis Optica Indicates Focal Tissue Damage

Abstract

Background: The long-term effect of neuromyelitis optica (NMO) on the brain is not well established. Methods: After 22 years of NMO, a patient’s brain was examinedbyquantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short-term NMO and 20 healthy subjects. Results: Although routine T1- and T2-weighted images appeared to be normal, quantitative T1-, T2- and diffusion-weighted magnetic resonance imaging identified areas with high diffusivity and altered relaxation time in ‘normal appearing white matter’ (NAWM). In such abnormal NAWM regions, biexponential diffusion analysis and quantitative spectroscopy indicated extracellular edema and axonal loss, respectively. Repeated analysis 6 months later identified the same alterations. Such patchy alterations were not detectable in the NAWM of the 3 cases with short-term NMO, and they were also not quantitatively different from the controls. Conclusion: After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months.

The Urine Proteome Profile Is Different in Neuromyelitis Optica Compared to Multiple Sclerosis: A Clinical Proteome Study

“…In MS it is widely accepted that the inflammatory process is caused or propagated by an autoimmune cascade involving myelin reactive T cells, resulting in widespread demyelination and neuronal and axonal degeneration[ 22 – 24 ]. Deposition of pathogenic antibodies and complement activation may be more prominent in NMO, while axonal degeneration is less pronounced[ 1 – 3 , 25 ]. However, MS is not a homogenous disease[ 24 ].…”