Quantitative prediction of aspiration risk in head and neck cancer patients treated with radiation therapy

Liu, Hannah C.; Williamson, Casey W.; Zou, Jingjing; Todd, Jacob R.; Nelson, Tyler J.; Hill, Lindsay M.; Linnemeyer, Kristen; Henderson, G.E.; Madgula, Puja; Faung, Brian; Sacco, Assuntina G.; Vitzthum, Lucas K.; Weissbrod, Philip A.; Blumenfeld, Liza; Mell, Loren K.

doi:10.1016/j.oraloncology.2022.106247

Cited by 7 publications

(3 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another difference between our study and the previous literature was the inclusion of patients treated with proton therapy for a sizable portion of the cohort (35%). Patients treated with protons were included in Liu et al 34 but they were only 5% of the cohort and no explicit analysis was performed using that information nor was dose analysis performed. Although radiation type was not a significant independent predictor in our study, it did serve to reduce the mean epiglottis dose from 53.7 ± 11.0 Gy for photon patients to 43.9 ± 13.6 Gy for proton patients.…”

Section: Discussionmentioning

confidence: 99%

Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes

Pepin,

Anaya,

Garces

et al. 2024

Advances in Radiation Oncology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes

Pepin,

Anaya,

Garces

et al. 2024

Advances in Radiation Oncology

View full text Add to dashboard Cite

“…The quantitative of VFSS based on pathological samples collected from a wide range of individuals with multiple diseases, the extraction of the most effective and valuable information from dysphagia angiography and the objective comparison of the levels of functionality within-patients before and after treatment, as well as between patients, can fully meet the comprehensive needs of scientific research, stimulate more innovative research, and generate ideas and references for the evaluation and follow-up treatment of dysphagia. For now, the quantitative analysis of VFSS is mainly used to describe the physiological state of swallowing ( 14 , 38 ), explore the pathological and physiological characteristics of swallowing in different diseases ( 23 , 39 ), analyze the effects of age, gender, texture of food balls and other factors on swallowing ( 40 , 41 ), and evaluate treatment efficacy ( 42 , 43 ). In the future, the quantitative results should be used for evaluation, and future studies should assess other valuable parameters and improve those with poor reliability, validity, and matching.…”

Section: Discussionmentioning

confidence: 99%

Findings of a videofluoroscopic swallowing study in patients with dysphagia

Cui

Wei

et al. 2023

Front. Neurol.

View full text Add to dashboard Cite

ObjectiveSwallowing examination is crucial in patients with dysphagia. We aimed to compare qualitative and quantitative videofluoroscopic swallowing study (VFSS) results to provide reference for standardizing quantitative parameters.Materials and methodsIn total, 117 patients with dysphagia were included, 38 with Parkinson’s disease and 39 and 40 in convalescence following cerebral hemorrhage and infarction. VFSS was both qualitatively and quantitatively analyzed.ResultsA significant difference of Oral transit time was found between the oral motor function grades (p < 0.001), also was swallowing reaction times found between swallowing reaction duration grades (p < 0.001), and soft palate lift duration between the soft palate lift grades (p < 0.001). Superior hyoid bone movement (p < 0.001), anterior hyoid bone movement (p < 0.001), hyoid pause time (p < 0.001), and hyoid movement duration (p = 0.032) had significant differences between the hyoid laryngeal complex movement grades, as did the pharyngeal cavity transit time among the cricopharyngeal muscle opening duration grades (p < 0.001). The laryngeal vestibule closure duration differed among the glottic closure grades (p < 0.001). No statistically significant difference in upper esophageal sphincter opening diameter (p = 0.682) or duration (p = 0.682) among the cyclopharyngeal muscle opening duration grades. The pharyngeal area at rest did not significantly differ among the different vallecular residue (p = 0.202) and pyriform sinus residue (p = 0.116) grades.ConclusionSeveral quantitative parameters can reflect the swallowing assessment process well. Further optimization of quantitative parameters is recommended.

show abstract

“…Xu et al mention that 5 years after the end of the treatment, a quarter of this category of patients will be affected by aspiration pneumonia. Tumor stage is identified as a risk factor by Liu et al; patients with ≥2 risk factors have a risk of 2.5 times more to aspire after the completion of radiotherapy treatment [36,37].…”

Section: Case Reportmentioning

confidence: 99%

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

Mireștean,

Simionescu,

Iancu

et al. 2023

Diagnostics

View full text Add to dashboard Cite

Chondrosarcoma represents approximately 0.1% of all neoplasms of the head and neck and is considered a rare disease with a relatively good prognosis. The 5-year overall survival (OS) rate is estimated at 70–80%, being considered a disease with a low growth rate. Approximately 13% of all cases of chondrosarcoma are located in the region of the head and neck. We present the case of a 30-year-old patient without a medical history who reported dysphagia, swallowing difficulty, neck mass sensation and dysphonia that started insidiously after an upper respiratory tract infection. Subsequently, the patient was diagnosed with a low-grade glosso-epiglottic region chondrosarcoma and was multimodally treated with surgery followed by chemotherapy and radiotherapy. The radiation treatment was delivered with a Rokus M40 former Soviet Union cobalt machine without any image guidance capabilities. The inability to obtain resection margin information justified an aggressive adjuvant treatment with chemotherapy and radiotherapy. The early loss from the oncological record without recurrence of the disease could be associated in this case with the consequence of a major complication, of which we could assume an aspiration pneumonia secondary to a dysphagia associated with an aggressive multidisciplinary treatment. Large tumor size and positive resection margins (R1 resection) are risk factors that support an intensive adjuvant approach in order to reduce the risk of recurrence, but the low grade of tumor associated with a lower risk of recurrence as well as the adverse events (AE) of adjuvant radiotherapy and chemotherapy justify a more reserved therapeutic approach. Taking into account the longer life expectancy of these patients, it is recommended to use a more conformal irradiation technique in order to reduce doses to radiosensitive structures as well as to omit elective neck irradiation, taking into account the lower risk of lymph node involvement. The lack of guidelines, which include very rare tumors including low grade chondrosarcoma of the head and neck, makes a unified approach difficult, but the data presented in case reports could contribute to choosing the regimen that offers the best therapeutic ratio.

show abstract

Quantitative prediction of aspiration risk in head and neck cancer patients treated with radiation therapy

Cited by 7 publications

References 32 publications

Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes

Radiation Dose Sensitivity of Subregions of the Larynx to Patient-Reported Swallowing Outcomes

Findings of a videofluoroscopic swallowing study in patients with dysphagia

Head and Neck Low Grade Chondrosarcoma—A Rare Entity

Contact Info

Product

Resources

About