Quantitative profiling of glycerides, glycerophosphatides and sphingolipids in Chinese human milk with ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

Zhao, Jianxin; Liu, Qian; Liu, Yan; Qiao, Weicang; Yang, Kai; Jiang, Tiemin; Hou, Juncai; Zhao, Yang; Lin, Tie; Li, Nan; Chen, Lijun

doi:10.1016/j.foodchem.2020.128857

Cited by 42 publications

(42 citation statements)

References 31 publications

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“…A previous study reported remarkable variations in the human milk FA profile over different lactation stages. 7 As TAGs constituted of FAs account for about 98% of the human milk lipid, there may also be divergence in TAG composition. Therefore, we further investigated the changes in the human milk TAG composition along lactation periods in the present study.…”

Section: (Esi †)mentioning

confidence: 99%

“…6 Lipids are the second-largest component in HBM, mainly including glycerides, polar lipids, sterols, and glycolipids. 7 Ninety-eight percent of the milk fat consists of glycerides encompassed by three subclasses of triacylglycerols (TAGs), diglycerides (DAGs) and monoglycerides. According to the composition of fatty acids (FAs), the three subclasses of human milk glycerides contain various molecular species.…”

Section: Introductionmentioning

confidence: 99%

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Profiling of triacylglycerol composition in the breast milk of Chinese mothers at different lactation stages

et al. 2022

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Section: (Esi †)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Profiling of triacylglycerol composition in the breast milk of Chinese mothers at different lactation stages

et al. 2022

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“…Breast milk samples are self-collected by mothers ( 62 ) at 1–5 days, 10–15 days, 1 month, 4 months, and 12 months after delivery. Human milk glycerides, phospholipids, and sphingolipids will be profiled using ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry [UPLC/Q-TOF-MS with electrospray ionization source (ESI)] ( 63 ). Meanwhile, the human milk oligosaccharides (HMO) will be quantified using ultra-high-pressure liquid chromatography (UHPLC) with fluorescence detection ( 64 ).…”

Section: Methods and Analysismentioning

confidence: 99%

MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia

et al. 2022

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BackgroundThe microbiota plays a key role in early immunity maturation that affects infant health and is associated with the development of non-communicable diseases and allergies in later life.ObjectiveThe MYBIOTA is a prospective mother-infant cohort study in Malaysia aiming to determine the association between gut microbiota with infant health (temperament, gastrointestinal disorders, eczema, asthma, and developmental delays) in Selangor, Malaysia.MethodsPregnant mothers will be enrolled in their first trimester of pregnancy, and follow-ups will be done for infants during their first year of life. Maternal-infant biological samples (blood, feces, saliva, urine, and breast milk), anthropometric, dietary, and clinical information will be collected at different time points from early pregnancy to 12 months postpartum.DiscussionThis study could provide a better understanding of the colonization and development of the gut microbiome during early life and its impact on infant health.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT04919265.

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“…The higher O-P-L content in Chinese human milk was related to the higher consumption of linoleic acid in Chinese mothers. For example, olive oil with a content of oleic acid of more than 80% was widely used in cooking in western countries (32), while soybean oil and sunflower oil containing ∼50-60% linoleic acid were consumed more in China (19, 25).…”

Section: Chinese Human Milk Was Highly Rich In O-p-l Than Western Cou...mentioning

confidence: 99%

Medium- and long-chain triacylglycerols and di-unsaturated fatty acyl-palmitoyl-glycerols in Chinese human milk: Association with region during the lactation

Yan²,

Mi³

et al. 2022

Front. Nutr.

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The triacylglycerols (TAGs) of medium- and long-chain triacylglycerols (MLCT) and di-unsaturated fatty acyl-palmitoyl-glycerols (UPU) in human milk provide better nutritional effects, and should be prioritized as crucial focuses on neonatal nutrition research. However, little has been done on the influences of the lactation stage and regional diversity on MLCT and UPU. In this study, we collected 204 human milk samples during colostrum, 1st and 4th month from the north (Baotou), central (Beijing), east (Jinan), southwest (Kunming), southeast (Shenzhen), and northwest (Xining) regions of China. There were 122 species of TAGs detected with UPLC-Q-TOF-MS, including 60 kinds of MLCT and 15 kinds of UPU. The MLCT and UPU type TAGs in human milk were ~27 and ~38%, respectively. The sum content of MLCT and UPU in human milk was stable. Compared to the regional diversity, lactation stages showed more obvious influences on MLCT and UPU composition. Moreover, a summary of TAG studies indicated that Chinese human milk showed a higher ratio of O-P-L to O-P-O than in western countries.

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Quantitative profiling of glycerides, glycerophosphatides and sphingolipids in Chinese human milk with ultra-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry

Cited by 42 publications

References 31 publications

Profiling of triacylglycerol composition in the breast milk of Chinese mothers at different lactation stages

Profiling of triacylglycerol composition in the breast milk of Chinese mothers at different lactation stages

MYBIOTA: A birth cohort on maternal and infant microbiota and its impact on infant health in Malaysia

Medium- and long-chain triacylglycerols and di-unsaturated fatty acyl-palmitoyl-glycerols in Chinese human milk: Association with region during the lactation

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