Quantitative proteomics of plasma and liver reveals the mechanism of turmeric in preventing hyperlipidemia in mice

Wang, Meiqin; Wang, Runjing; Li, Lieyao; Yan, Yingfei; Jia, Shuailong; Jiang, Hongliang; Du, Zhifeng

doi:10.1039/d1fo01849c

Cited by 9 publications

(7 citation statements)

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“…Obesity is typically associated with body weight and dyslipidemia, which encompasses elevated levels of TC, TG, and LDL-C as well as lowered HDL-C levels. All of these are risk factors for cardiovascular disease (Skrypnik et al, 2018 ; Wang et al, 2021 ). The long-term exposure of high-fat diet seems to have a significant relation to the onset of obesity from various rat model studies (Yin et al, 2010 ; Lasker et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…Under normal conditions, the liver, which is an important site of lipid metabolism in the body, maintains a balance of lipid synthesis and decomposition, whereas a high-fat diet disrupts this balance, causing excessive lipid accumulation (i.e., hepatic steatosis) and oxidative stress in the liver, indicating the presence of liver injury (Skrypnik et al, 2018 ; Wang et al, 2021 ). Accumulation of lipids in the liver is the main cause of non-alcoholic fatty liver disease (NAFLD), which is a common complication of obesity (Skrypnik et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Accumulation of lipids in the liver is the main cause of non-alcoholic fatty liver disease (NAFLD), which is a common complication of obesity (Skrypnik et al, 2018 ). Furthermore, multiple studies have shown that obesity is directly connected with body-liver weight, liver TC and liver TG, and serum lipid profiles in high-fat diet-induced obese rats (Skrypnik et al, 2018 ; Wang et al, 2021 ; Yang et al, 2021 ). In our experiments, it was evident that the high-fat diet-fed rats (HCD rats) showed an increased TC and TG levels from both the serum and liver tissue homogenate, which further triggered the lipid accumulation and lipotoxicity in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…Over the last decades, the ubiquity of hyperlipidemia among people throughout the world has inflated and attained an epidemic level (Zhang et al, 2021 ). Hyperlipidemia is a condition in which the plasma or serum contains elevated levels of total cholesterol (TC) and/or triglycerides (TG) and/or low-density lipoprotein (LDL); and low levels of high-density lipoprotein (HDL) (Wang et al, 2021 ). Numerous aspects like environmental factors, unhealthy food habits, and heredity may be the cause of hyperlipidemia.…”

Section: Introductionmentioning

confidence: 99%

“…Numerous aspects like environmental factors, unhealthy food habits, and heredity may be the cause of hyperlipidemia. Whatever be the causative factors of hyperlipidemia, long-term exposure to such a condition as hyperlipidemia may be followed by various health issues like cardiovascular diseases, cerebrovascular diseases, atherosclerosis, metabolic syndrome, and many chronic diseases (Skrypnik et al, 2018 ; Wang et al, 2021 ). Although the use of drug therapy (statins, fibrate, etc.)…”

Section: Introductionmentioning

confidence: 99%

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Revealing Probiotic Potential of Enterococcus Strains Isolated From Traditionally Fermented Chhurpi and Healthy Human Gut

Ghatani

Thapa

Sha³

et al. 2022

Front. Microbiol.

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In this study, the two lactic acid bacterial strains Enterococcus durans and Enterococcus lactis previously isolated from soft chhurpi, a traditionally fermented milk product prepared by the indigenous community of Sikkim Himalayas and healthy human gut were used. In this study, we attempted to investigate the probiotic attributes, safety, and health beneficial role, and hypercholesterolemia of Enterococcus durans and Enterococcus lactis. Both probiotic potential strains showed good hypocholesterolemic activity in vitro along with tolerance to acid pH (2 and 2.5), tolerance to three bile salts, oxbile, cholic acid, and taurocholic acid (0.5 and 1%), presence of BSH enzyme and its activity, and cell surface adherence. On assessing for safety, both LAB strains were sensitive to antibiotics and exhibited no hemolytic activity. The probiotic strains were tested in vivo in the Sprague–Dawley rats which were divided into five experimental groups: Normal Control (ND), probiotic strain Enterococcus durans HS03 (BSH-negative) and high-cholesterol diet (HCD1), probiotic strain Enterococcus lactis YY1 (BSH-positive) and high-cholesterol diet (HCD2), and a combination of both strains and high-cholesterol diet (HCD3) and Negative Control (HCD). The probiotic-treated groups HCD1, HCD2, and HCD3 showed a decrease in serum cholesterol levels up to 22.55, 6.67, and 31.06%; the TG and VLDL concentrations were 25.39, 26.3, and 33.21%; reduction in LDL-cholesterol was 33.66, 28.50, and 35.87%; and increase of HDL was 38.32, 47.9, and 41.92%. Similarly, the effects of total cholesterol and TG in the liver, kidney and liver histopathology, liver and body lipid index, and oxidative stress in rat liver were also studied. The fecal lactobacilli were more in the samples of the probiotic-treated groups and their fecal coliform and E. coli counts decreased relatively as compared to the control groups in 0, 7, 14, and 21 days. This is the first report on the probiotic potential of Enterococcus durans HS03 and Enterococcus lactis YY1 strains that gives a new insight into the cholesterol-lowering and probiotic product development with wide health attributes.

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