Quantitative Proton Magnetic Resonance Spectroscopic Determination of Nifedipine and Its Photodecomposition Products from Pharmaceutical Preparations

Towards Understanding Drugs on the Molecular Level to Design Drugs of Desired Profiles

“…The photodegradation of NIF in solution has been widely studied [178] whereas only a few authors have studied it in solid [179]. The photostability and the photostabilization of NIF in different solid formulations including powders and tablets have received considerable attention [180]. A typical approach to study these phenomena is based on a combination of different techniques.…”

Shedding Blue Light on the Undergraduate Laboratory: An Easy-to-Assemble LED Photoreactor for Aromatization of a 1,4-Dihydropyridine

“…The nifedipine, nimodipine, and 1,4-DHP used in this experiment are oxidized in the liver by cytochrome P-450 to produce the corresponding pyridine derivative . On the other hand, during the industrial synthesis of several 1,4-DHPs, pyridine derivatives are commonly obtained as the main impurities . This could affect the effectiveness, safety, and quality of drugs available on the market, hence the importance of becoming familiar with this type of photochemical transformation.…”