Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period

Heijtink, R. A.; Waart, M. van der; Weimar, Willem; Schalm, Solko W.; Masurel, N.

doi:10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>3.0.co;2-5

Cited by 8 publications

(3 citation statements)

References 26 publications

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“…The fall in HB,Ag titre in case 3 from 1: 32 000 to undetectable concentrations by reverse passive haemagglutination in successive tests, a highly significant reduction, is of great interest particularly because the HB.Ag titres are usually constant in patients with chronic active hepatitis (Heijtink et al, 1980). This phenomenon would support the theory of viral interference (Dulbecco and Ginsberg, 1973) which suggests that simultaneous infection with 2 viruses results in inhibition of multiplication of one of them.…”

Section: Discussionmentioning

confidence: 82%

“…This phenomenon would support the theory of viral interference (Dulbecco and Ginsberg, 1973) which suggests that simultaneous infection with 2 viruses results in inhibition of multiplication of one of them. In addition, it has been suggested (Heijtink et al, 1980) that the introduction of a foreign antigen results in interferon production and consequent reduction in viral particle synthesis, a view supported by the results of parenteral interferon administration in this group of patients (Greenberg et al, 1976).…”

Section: Discussionmentioning

confidence: 89%

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The clinical course of acute type A hepatitis in chronic HBsAg carriers—a report of 3 cases

Viola

Coleman

Barrison

et al. 1982

Postgraduate Medical Journal

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Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 89%

The clinical course of acute type A hepatitis in chronic HBsAg carriers—a report of 3 cases

Viola

Coleman

Barrison

et al. 1982

Postgraduate Medical Journal

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“…that these treatments could reduce, at least transiently, HBV replication, one should also take into account the possibility of spontaneous temporal fluctuations in DNAP levels, as recently noted by Weimar et a1 [1977] in untreated HBsAg carriers and by Heijtink et al [1980] in similar patients receiving an influenza vaccination.…”

mentioning

confidence: 93%

Changes in hepatitis B virus DNA‐polymerase activity in patients with chronic infection

Alberti

Pontisso

Realdi

1981

Journal of Medical Virology

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Levels of serum hepatitis B virus DNA-polymerase (HBV-DNAP) were studied longitudinally over variable periods of time in 16 HBV chronic carriers using a modified assay procedure developed to increase reproducibility. Ten patients were tested on a short-term basis at 3- to 6-hr intervals for 48 hr or at 24- to 48-hr intervals for 15 consecutive days, and all showed marked vacillations in enzyme levels although hospitalized and untreated. Patients with chronic active hepatitis on liver biopsy had larger fluctuations compared to cases of chronic persistent hepatitis. Six patients were longitudinally tested over a period of 12-32 months and those three receiving immunosuppressive drugs showed a progressive increase in DNAP levels during therapy, but two returned to pretreatment levels after therapy was withdrawn and one even cleared permanently the complete virus with seroconversion to anti-HBe. Such outcome was also observed in one patient with chronic active hepatitis who remained untreated.

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Influenza vaccination in HBsAg positive chronic active hepatitis patients treated with interferon

Heijtink

Masurel

Weimar

et al. 1980

Med Microbiol Immunol

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Sixteen patients with hepatitis B antigen (HBsAg) positive chronic active hepatitis (CAH) were vaccinated with the nonhuman influenza A virus Heq1Neq1; eight patients were also treated with leucocyte interferon. Pre-vaccination sera were negative for specific antibody in hemagglutination inhibition tests. Four weeks after vaccination all patients had responded with a homologous antibody titer. Between the interferon-treated and the untreated groups the differences in antibody titers against the vaccine virus were not significant. Concomitant with the antibody response against the nonhuman influenza virus, a fourfold or higher antibody rise was observed against the influenza A virus strains Hsw1N1 (in six treated with seven untreated patients), H1N1 (in six treated and four untreated patients) and H3N2 (in five treated patients only). The results suggest that a normal specific antibody response in HBsAg positive chronic active hepatitis patients is not significantly altered by leucocyte interferon, and that non-specific antibody production can occur in the absence of a serologic relationship.

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Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period

Cited by 8 publications

References 26 publications

The clinical course of acute type A hepatitis in chronic HBsAg carriers—a report of 3 cases

The clinical course of acute type A hepatitis in chronic HBsAg carriers—a report of 3 cases

Changes in hepatitis B virus DNA‐polymerase activity in patients with chronic infection

Influenza vaccination in HBsAg positive chronic active hepatitis patients treated with interferon

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