The clinical course of acute type A hepatitis in chronic HBsAg carriers—a report of 3 cases

Viola, Luis; Coleman, John; Barrison, I. G.; Murray‐Lyon, Iain M.

doi:10.1136/pgmj.58.676.80

Cited by 41 publications

(17 citation statements)

References 10 publications

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“…Our results confirm previous findings that acute HAV infection does not cause severe liver injury in patients with chronic HBV infection, [16][17][18][19][20] but they differ from the findings of other large series. 2 It is not easy to reconcile such differences; however, in other studies, most HBV-infected patients with fulminant hepatitis A had cirrhosis, the role of HCV was not evaluated, and the possibility of coinfections with HBV and HCV could not be ruled out.…”

Section: Discussionsupporting

confidence: 76%

Fulminant Hepatitis Associated with Hepatitis A Virus Superinfection in Patients with Chronic Hepatitis C

et al. 1998

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Section: Discussionsupporting

confidence: 76%

Fulminant Hepatitis Associated with Hepatitis A Virus Superinfection in Patients with Chronic Hepatitis C

et al. 1998

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“…Viola e cols. 20 e Zachoval e cols. 21 não encontraram diferenças nos níveis de bilirrubina, transaminases e nem na evolução de pacientes portadores crônicos do vírus B, com infecção aguda por HVA.…”

Section: Discussionunclassified

Prevalência do anticorpo da hepatite A em crianças e adolescentes com hepatopatia crônica

Ferreira¹,

Taniguchi²,

Vieira³

et al. 2002

J. Pediatr. (Rio J.)

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ResumoObjetivo: avaliar a prevalência de hepatite viral A (HVA) em crianças e adolescentes portadores de doenças crônicas do fígado, em um serviço de hepatologia pediátrica.Métodos: entre maio de 1999 e fevereiro de 2001, foi estudada a prevalência de anticorpos anti-HVA total em 60 crianças e adolescentes, entre 1 e 16 anos de idade, portadoras de hepatopatias crônicas, provenientes da unidade de gastroenterologia pediátrica e programa de transplante hepático infantil do serviço de pediatria do Hospital de Clínicas de Porto Alegre. O anti-HVA, realizado através de um teste laboratorial comercialmente disponível em nosso meio (Abbott -MEIA HAVAB -sistema AXSYM), foi determinado e relacionado com a idade, com o sexo, com a cor, com o diagnóstico etiológico da hepatopatia e com a renda familiar dos pacientes.Resultados: apenas uma criança de 1 ano, portadora de atresia biliar, foi excluída do estudo por apresentar anti-HVA indeterminado, em duas ocasiões. Das 59 crianças restantes, 14 (24%) apresentavam resultados positivos para o anti-HVA total. As idades dos pacientes com anti-HVA positivos variaram de 1 a 16 anos (x= 7,7 anos e mediana 8,5 anos). Não houve diferença significante entre idade, sexo e cor entre os grupos positivo e negativo. A renda familiar foi menor no grupo dos pacientes anti-HVA positivo, mas não mostrou diferença estatística significante. A diferença de prevalên-cia de anti-HVA entre as etiologias das hepatopatias está, provavelmente, relacionada à idade mais do que ao diagnóstico.Conclusões: na população estudada, a maioria (76%) das crianças e adolescentes portadoras de hepatopatias crônicas é suscetível à infecção pelo vírus A, podendo apresentar, portanto, um curso mais grave e complicações, se adquirirem HVA. Sugerimos, então, que esses pacientes devam receber a vacina inativada contra HVA.J Pediatr (Rio J) 2002;78(6):503-8: hepatite viral A, prevalên-cia, anticorpo anti-HVA, hepatopatias crônicas. AbstractObjective: to evaluate the prevalence of Hepatitis A virus (HAV) in children and adolescents with chronic liver disease in a unit of pediatric hepatology.

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“…Other papers refer to the course of acute HA in groups of institutionalized persons with past contact with HBV as being either milder [6] or aggravated [7]. More recently it has been concluded that HAV superinfection in HBsAg carriers neither causes a more severe illness, nor affects the course of chronic HB [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Dissociation of alanine aminotransferase values in acute hepatitis A patients with and without past experience to the hepatitis B virus

Papachristou¹,

Katsouyannopoulos

1991

Epidemiol. Infect.

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SUMMARYSerological markers and peak serum alanine aminotransferase (ALT) values of 140 in-patients with acute hepatitis, either type A (n = 90), or type B (n = 50) were prospectively assessed. In 23 out of the 90 patients with acute hepatitis A, evidence of previous experience with hepatitis B virus (HBV) was found, whereas 35 out of the 50 patients with acute hepatitis B had past contact with hepatitis A virus (HAV). The mean peak ALT values [S.D.] were significantly higher in hepatitis A patients with previous experience with HBV (1413 [704] i.u./l), when compared to those without such experience (842 [464] i.u./l, P < 0-001). Such a difference was not evident between acute hepatitis B patients, whether or not they had previous contact with HAV. We conclude that when acute hepatitis A is superimposed on past HBV infection an augmented transaminaemia, indicative of enhanced liver cell necrosis, takes place although a definite explanation is lacking. We suggest that individuals with markers of HBV infection should be early candidates for HAV immunization.

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The clinical course of acute type A hepatitis in chronic HBsAg carriers—a report of 3 cases

Cited by 41 publications

References 10 publications

Fulminant Hepatitis Associated with Hepatitis A Virus Superinfection in Patients with Chronic Hepatitis C

Fulminant Hepatitis Associated with Hepatitis A Virus Superinfection in Patients with Chronic Hepatitis C

Prevalência do anticorpo da hepatite A em crianças e adolescentes com hepatopatia crônica

Dissociation of alanine aminotransferase values in acute hepatitis A patients with and without past experience to the hepatitis B virus

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