Quantitative Sonography of Muscle

Heckmatt, J. Z.; Rodillo, E.; Doherty, Mark; Willson, Keith; Leeman, S.

doi:10.1177/0883073889004001s15

Cited by 66 publications

(47 citation statements)

References 11 publications

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“…Previous ultrasound studies of skeletal muscle have expressed results as uncalibrated grayscale values without ensuring that values fell within a linear range. 7,14,15,20,21 Our method also expresses backscatter values relative to an external reference, a tissue-mimicking phantom with reproducible ultrasound characteristics. This allows reproducibility and comparison among different ultrasound set-ups.…”

Section: Discussionmentioning

confidence: 99%

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Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis

et al. 2008

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We evaluated the ability of an ultrasound method, which can characterize cardiac muscle pathology and has reliability across different imaging systems, to obtain calibrated quantitative estimates of backscatter of skeletal muscle. Our procedure utilized a tissue-mimicking phantom to establish a linear relationship between ultrasound grayscale and backscatter levels. We studied skeletal muscles of 82 adults: 45 controls and 37 patients with hereditary myopathies. We found that skeletal muscle ultrasound backscatter levels varied with probe orientation, age, and muscle contraction and pathology. Reliability was greater with the probe in longitudinal compared with transverse planes. Backscatter levels were higher in those >40 years of age, in muscle extension than flexion, and in myopathic patients than controls. Calibrated measurements of muscle backscatter have sensitivity and specificity in identifying and reliably measuring levels of skeletal muscle pathology.

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Section: Discussionmentioning

confidence: 99%

“…5,7,14,20,21,25 Its advantages are that it is rapid, non-invasive, painless, and inexpensive. Analyses of ultrasound images of muscle in clinical practice most commonly focus on qualitative features.…”

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confidence: 99%

Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis

et al. 2008

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“…10,42,98 Quantification of muscle echo intensity improved the sensitivity to 87%-92%. 35,62,64,67 With this high sensitivity, muscle ultrasound is very suitable for screening purposes. 62 In adults, no prospective studies investigating the diagnostic value of muscle ultrasound have yet been performed.…”

Section: Ultrasound In Neuromuscular Disordersmentioning

confidence: 99%

“…6). 5,35,54,55,64,69,74 Because this is more objective and allows for statistical analysis, it is a robust clinical technique and is also very suitable for research purposes. Quantitative techniques improve the interobserver agreement (kappa ϭ 0.86).…”

Section: Figurementioning

confidence: 99%

Muscle ultrasound in neuromuscular disorders

2008

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Muscle ultrasound is a useful tool in the diagnosis of neuromuscular disorders, as these disorders result in muscle atrophy and intramuscular fibrosis and fatty infiltration, which can be visualized with ultrasound. Several prospective studies have reported high sensitivities and specificities in the detection of neuromuscular disorders. Although not investigated in large series of patients, different neuromuscular disorders tend to show specific changes on muscle ultrasound, which can be helpful in differential diagnosis. For example, Duchenne muscular dystrophy results in a severe, homogeneous increase of muscle echo intensity with normal muscle thickness, whereas spinal muscular atrophy shows an inhomogeneous increase of echo intensity with severe atrophy. A major advantage of muscle ultrasound, compared to other imaging techniques, is its ability to visualize muscle movements, such as muscle contractions and fasciculations. This study reviews the possibilities and limitations of ultrasound in muscle imaging and its value as a diagnostic tool in neuromuscular disorders.

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“…These changes can be determined by muscle histology, the results of which have been reported to be correlated with US measurements in many studies (Brockmann et al 2007;Heckmatt et al 1989;Maurits et al 2003Maurits et al , 2004. Normal muscles appear as low echo-intensity structures; increased muscle echo intensity is indicative of a neuromuscular disorder (Pillen et al 2008).…”

Section: Introductionmentioning

confidence: 96%

Application of Ultrasonography in the Assessment of Skeletal Muscles in Children with and without Neuromuscular Disorders: A Systematic Review

Rahmani¹,

Mohseni-Bandpei

Vameghi

et al. 2015

Ultrasound in Medicine & Biology

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The purpose of this study was to systematically review published studies (2000-2014) carried out on the application of ultrasonography (US) to evaluation of skeletal muscle size in children with and without neuromuscular disorders. Different databases including PubMed, Science Direct, OVID, MEDLINE, CINAHL, EMBASE, ProQuest and Google Scholar were searched. The key words used were: "children," "ultrasound," "skeletal muscles," "neuromuscular disease," "neurogenic disorders," "spina bifida," "myelomeningocele" and "reliability." Eighteen articles were found to be relevant. Eight studies applied US in combination with additional methods of assessment. Four of the 18 studies did not have a control group. Ten studies applied only US in the assessment of skeletal muscles in children with and without neuromuscular diseases. In 9 studies, there were children ranging widely in age, and in 3 studies US was used to determine normal values for skeletal muscles. According to the results of these 18 reviewed articles, US is an appropriate, reliable and highly predictive method for assessment of skeletal muscles in children.

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Quantitative Sonography of Muscle

Cited by 66 publications

References 11 publications

Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis

Calibrated quantitative ultrasound imaging of skeletal muscle using backscatter analysis

Muscle ultrasound in neuromuscular disorders

Application of Ultrasonography in the Assessment of Skeletal Muscles in Children with and without Neuromuscular Disorders: A Systematic Review

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