Quantitative Study of the Effects of Cyclophosphamide on Peritoneal Cell Populations

Abstract

A quantitative study of peritoneal cell populations has been carried out in mice at intervals of 6 h to 30 days after a single sublethal dose of cyclophosphamide. There was a severe depletion in the number of lymphoid cells, which was first detected at 12 h and reached a maximum at 6 days. Macrophages were evident in the removal and disposal of degenerating cells, and showed increased numbers at 3 days. Recovery was rather slow, significant differences in small lymphocyte counts being still present at 18 days, and in other lymphocytes and blast cells at even later intervals.