Quantitative susceptibility mapping across two clinical field strengths: Contrast‐to‐noise ratio enhancement at 1.5T

Ippoliti, Matteo; Adams, Lisa C.; Brenner, Winfried; Hamm, Bernd; Spincemaille, Pascal; Wang, Yi; Makowski, Marcus R.

doi:10.1002/jmri.26045

Cited by 11 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several observations can be made from our measurements of susceptibility and

R_{2}^{*}

across a range of GA (under normoxia). Because magnetic susceptibility is independent of field strength, there was no significant difference in susceptibility measures between 1.5T and 3T, showing the 2 linear regression lines nicely overlapped for both mean and SD, which is in accordance with previous results in the brain 33 . In contrast,

R_{2}^{*}

was significantly higher at 3T than 1.5T, primarily due to increased intravoxel dephasing at a higher field, which is also consistent with results of the brain 34 .…”

Section: Discussionsupporting

confidence: 90%

“…Because magnetic susceptibility is independent of field strength, there was no significant difference in susceptibility measures between 1.5T and 3T, showing the 2 linear regression lines nicely overlapped for both mean and SD, which is in accordance with previous results in the brain. 33 In contrast, R * 2 was significantly higher at 3T than 1.5T, primarily due to increased intravoxel dephasing at a higher field, which is also consistent with results of the brain. 34 Also, it was notable that susceptibility and R * 2 showed very different distributions within the placenta as well as different changes with advancing GA. Susceptibility exhibited almost always nearly zero mean, with a symmetrical distribution and increasing SD with advancing GA. For R * 2 , both mean and SD increased with advancing GA; however, given that CV of R * 2 was almost consistent across GA, it can be inferred that spatial heterogeneity of R * 2 within the placenta was maintained, and only magnitude of R * 2 increased as a function of increasing GA.…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Feasibility of QSM in the human placenta

Zun

Kapse

Quistorff

et al. 2020

Magnetic Resonance in Med

View full text Add to dashboard Cite

Purpose: Quantitative susceptibility mapping (QSM) is an emerging tool for the precise characterization of human tissue, including regional oxygenation. A critical function of the human placenta is oxygen transfer to the developing fetus, which remains difficult to study in utero. The purpose of this study is to investigate the feasibility of performing QSM in the human placenta in utero. Methods: In healthy pregnant women, 3D gradient echo data of the placenta were acquired with prospective respiratory gating at 1.5 Tesla and 3 Tesla. A brief period (6-7 min) of maternal hyperoxia was induced to increase placental oxygenation in a subset of women scanned at 3 Tesla, and data were acquired before and during oxygen administration. Susceptibility and T * 2 /R * 2 maps were reconstructed from gradient echo data, and mean and SD of these measures within the whole placenta were calculated. Results: A total of 54 women were studied at a mean gestational age of 30.7 ± 4.2 (range: 24 5/7-38 4/7) weeks. Susceptibility and T * 2 maps demonstrated lobular contrast reflecting regional oxygenation difference at both field strengths. SD of susceptibilities, mean R * 2 , and SD of R * 2 of the placenta showed a linear relationship with gestational age (P < .01 for all). These measures were also responsive to maternal hyperoxia, and there was an increasing response with advancing gestational age (P < .01 for all). Conclusion: This study demonstrates the feasibility of performing placental QSM in pregnant women and supports the potential for placental QSM to provide noninvasive in vivo assessment of placental oxygenation.

show abstract

“…Several observations can be made from our measurements of susceptibility and

R_{2}^{*}

R_{2}^{*}

was significantly higher at 3T than 1.5T, primarily due to increased intravoxel dephasing at a higher field, which is also consistent with results of the brain 34 .…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 87%

Feasibility of QSM in the human placenta

Zun

Kapse

Quistorff

et al. 2020

Magnetic Resonance in Med

View full text Add to dashboard Cite

show abstract

“…According to the published methods (14), the QSM reconstruction was achieved through the use of a C++ software developed and validated by Wang and his colleagues (15), and is based on nonlinear morphology-enabled dipole inversion (MEDI), which makes use of the consistency between the susceptibility maps and magnitude images obtained from the Spoiled Gradient Recalled Echo (SPGR) acquisitions. The susceptibility maps are obtained through estimating (nonlinearly) the phase maps, which have to be unwrapped and subsequently undergo dipole inversion.…”

Section: Methodsmentioning

confidence: 99%

Brain Iron Deposits in Thalamus Is an Independent Factor for Depressive Symptoms Based on Quantitative Susceptibility Mapping in an Older Adults Community Population

Zhang

Zhou

et al. 2019

Front. Psychiatry

View full text Add to dashboard Cite

Objectives: With the trend of an aging population, an increasing prevalence of late-life depression has been identified. Several studies demonstrated that iron deposition was significantly related to the severity of symptoms in patients with depression. However, whether brain iron deposits influence depressive symptoms is so far unclear in the community of older adults. We measured iron deposition in deep intracranial nucleus by quantitative susceptibility mapping (QSM) and aimed to explore the relationship between iron deposition and depressive symptoms. Methods: We reviewed the data of a community population from CIRCLE study, which is a single-center prospective observational study that enrolled individuals above 40 years old with cerebral small vessel disease (SVD), while free of known dementia or stroke. We evaluated regional iron deposits on QSM, measured the volume of white matter hyperintensities (WMHs) on T2 fluid-attenuated inversion recovery, and assessed depressive symptoms by Hamilton depression scale (HDRS). We defined depressive symptom as HDRS > 7. Results: A total of 185 participants were enrolled. Participants in depressive symptom group had higher QSM value in thalamus than control group (18.79 ± 14.94 vs 13.29 ± 7.64, p = 0.003). The QSM value in the thalamus was an independent factor for the presence of depressive symptoms (OR = 1.055; 95% CI: 1.011-1.100; p = 0.013). The regional QSM values in other areas were not associated with HDRS score (all p > 0.05). No significant correlations were observed between WMHs volume and HDRS score (p > 0.05), or regional QSM values and WMHs volume (all p > 0.05). Conclusions: Our study demonstrated that iron deposits in the thalamus were related to the depressive symptoms in older adults.

show abstract

“…Brain QSM measurements have good inter-scanner and same-scanner reproducibility for HC and patients, respectively. Ippoliti et al (2018) also evaluated the reproducibility and consistency of QSM across 1.5T and 3.0T field strengths and optimized the contrast-to-noise ratio (CNR) at 1.5T through bandwidth tuning. Feng et al (2018) evaluated the repeatability of QSM on a 3.0T scanner using 8 subjects and found that QSM results were highly reproducible across the four time scans.…”

Section: Introductionmentioning

confidence: 99%

Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study

Sethi

Miao

et al. 2021

Front. Neurosci.

View full text Add to dashboard Cite

PurposeTo evaluate the effect of resolution on iron content using quantitative susceptibility mapping (QSM); to verify the consistency of QSM across field strengths and manufacturers in evaluating the iron content of deep gray matter (DGM) of the human brain using subjects from multiple sites; and to establish a susceptibility baseline as a function of age for each DGM structure using both a global and regional iron analysis.MethodsData from 623 healthy adults, ranging from 20 to 90 years old, were collected across 3 sites using gradient echo imaging on one 1.5 Tesla and two 3.0 Tesla MR scanners. Eight subcortical gray matter nuclei were semi-automatically segmented using a full-width half maximum threshold-based analysis of the QSM data. Mean susceptibility, volume and total iron content with age correlations were evaluated for each measured structure for both the whole-region and RII (high iron content regions) analysis. For the purpose of studying the effect of resolution on QSM, a digitized model of the brain was applied.ResultsThe mean susceptibilities of the caudate nucleus (CN), globus pallidus (GP) and putamen (PUT) were not significantly affected by changing the slice thickness from 0.5 to 3 mm. But for small structures, the susceptibility was reduced by 10% for 2 mm thick slices. For global analysis, the mean susceptibility correlated positively with age for the CN, PUT, red nucleus (RN), substantia nigra (SN), and dentate nucleus (DN). There was a negative correlation with age in the thalamus (THA). The volumes of most nuclei were negatively correlated with age. Apart from the GP, THA, and pulvinar thalamus (PT), all the other structures showed an increasing total iron content despite the reductions in volume with age. For the RII regional high iron content analysis, mean susceptibility in most of the structures was moderately to strongly correlated with age. Similar to the global analysis, apart from the GP, THA, and PT, all structures showed an increasing total iron content.ConclusionA reasonable estimate for age-related iron behavior can be obtained from a large cross site, cross manufacturer set of data when high enough resolutions are used. These estimates can be used for correcting for age related iron changes when studying diseases like Parkinson’s disease, Alzheimer’s disease, and other iron related neurodegenerative diseases.

show abstract

Quantitative susceptibility mapping across two clinical field strengths: Contrast‐to‐noise ratio enhancement at 1.5T

Abstract: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1410-1420.

Cited by 11 publications

References 23 publications

Feasibility of QSM in the human placenta

Feasibility of QSM in the human placenta

Brain Iron Deposits in Thalamus Is an Independent Factor for Depressive Symptoms Based on Quantitative Susceptibility Mapping in an Older Adults Community Population

Iron Content in Deep Gray Matter as a Function of Age Using Quantitative Susceptibility Mapping: A Multicenter Study

Contact Info

Product

Resources

About