Quantitative Susceptibility Mapping for Drug-Addicted Human Brain

Wei, Jiaxu; Wang, Lihui; Zhang, Jian; Wei, Hongjiang; Zhang, Yuyao; Cheng, Xinyu; Li, Zhi; Yang, Feng; Zhu, Yue-Min

doi:10.1109/icsp.2018.8652449

Cited by 1 publication

(1 citation statement)

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“…The reconstruction of susceptibility MRI was performed by using STI suite version 3.0 (https://people.eecs.berkeley.edu/c hunlei.liu/software.html) as described in the previous study (21). In summary, phase image was combined with magnitude for new phase calculation.…”

Section: Quantitative Susceptibility Mappingmentioning

confidence: 99%

Beyond the Motor Cortex: Thalamic Iron Deposition Accounts for Disease Severity in Amyotrophic Lateral Sclerosis

Zhu

Wen

et al. 2022

Front. Neurol.

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ObjectivePrevious studies have reliably identified iron deposition in the motor cortex as potential pathogenesis of amyotrophic lateral sclerosis (ALS). Here, we intended to investigate iron deposition, gray matter (GM) atrophy, and their associations with disease severity in the motor cortex and the thalamus in patients with ALS.MethodsA total of 34 patients with ALS (age 51.31 ± 8.24 years, 23 males) and 34 nonneurological controls (age 50.96 ± 9.35 years, 19 males) were enrolled between 2018 and 2020. The Revised ALS Functional Rating Scale (ALSFRS-R) and the Penn upper motor neuron (UMN) score were measured. MRI data included quantitative susceptibility mapping (QSM) for iron deposition and three-dimensional (3D) T1 for gray matter volume. After a between-group comparison, Pearson's correlation coefficient was used for identifying correlations of iron deposition, GM volume, and clinical measurements.ResultsThe two-sample t-tests revealed increased iron deposition in the left precentral gyrus (peak voxel T = 4.78, PSVC = 0.03) and the thalamus (peak voxel: right: T = 6.38, PSVC < 0.001; left: T = 4.64, PSVC = 0.02) in patients with ALS. GM volume of the precentral gyrus (T = −2.42, P = 0.02) and the bilateral thalamus (T = −4.10, P < 0.001) were reduced. Negative correlations were found between the increased QSM values and the decreased GM volume (P < 0.04, one-tailed) in patients with ALS. Iron deposition in the left precentral gyrus was positively correlated with the UMN score (R = 0.40, P = 0.02) and the GM volume was negatively correlated with the UMN score (R = −0.48, P = 0.004). Negative correlation between thalamic iron deposition and the ALSFRS-R (R = −0.36, P = 0.04) score was observed.DiscussionIron deposition in the thalamus, in addition to the motor cortex, is accompanied by GM atrophy and is associated with disease severity in patients with ALS, indicating that the thalamus is also a pathological region in patients with ALS.

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Section: Quantitative Susceptibility Mappingmentioning

confidence: 99%