Quantitative TLC Determination of Epimeric Ratios of 16-Methyl 17-Ketone Oxidation Products of Dexamethasone and Related Drugs

Juenge, Eric C.; Flinn, Paul E.

doi:10.1002/jps.2600700418

Journal of Pharmaceutical Sciences

1981

DOI: 10.1002/jps.2600700418

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Quantitative TLC Determination of Epimeric Ratios of 16-Methyl 17-Ketone Oxidation Products of Dexamethasone and Related Drugs

Eric C. Juenge¹,

Paul E. Flinn²

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1983

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Cited by 5 publications

References 17 publications

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A validated, stability-indicating method for the assay of dexamethasone in drug substance and drug product analyses, and the assay of preservatives in drug product

Spangler¹,

Mularz²

2001

Chromatographia

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A new high-performance liquid chromatographic (HPLC) procedure for the determination of dexamethasone, impurities, degradation products and product preservatives is described. A three-stage, linear gradient with UV detection at 240 nm allows the analysis of dexamethasone drug substance and dexamethasone in I',,vo formulated products, using the same chromatographic system. The Limit of Quantitation (LOQ) of dexamethasone impurities in drug substance is 0.05%, and 0.1% for dexamethasone degradation products in formulated products. The method is linear, precise, accurate and robust. Sample preparations are simple, and are accomplished without the use of an internal standard. Several degradation products of stressed dexamethasone have been identified.

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A validated, stability-indicating method for the assay of dexamethasone in drug substance and drug product analyses, and the assay of preservatives in drug product

Spangler¹,

Mularz²

2001

Chromatographia

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show abstract

Application of polarography and voltammetry to drug analysis in industry

Bersier

1983

Journal of Pharmaceutical and Biomedical Analysis

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Biotransformation of α-Terpinene in Common Cutworm Larvae (Spodoptera lituraFabricius)

Miyazawa

Wada

Kameoka

1996

J. Agric. Food Chem.

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α-Terpinene was mixed in an artificial diet at a concentration of 10 mg/g of diet, and the diet was fed to the last instar larvae of common cutworm, Spodoptera litura Fabricius. Metabolites were recovered from frass and analyzed spectroscopically. The α-terpinene was transformed mainly to 4-isopropyl-1,3-cyclohexadienoic acid and cumic acid. The allylic methyl group of α-terpinene was preferentially oxidized. The results indicate that the intestinal bacteria probably participated in the metabolism of α-terpinene. The aerobically active intestinal bacteria transformed α-terpinene to 4-isopropyl-1,3-cyclohexadienemethanol, and the anaerobically active intestinal bacteria transformed α-terpinene to p-cymene. Keywords: Common cutworm; Spodoptera litura Fabricius; larvae; biotransformation; α-terpinene; allylic oxidation; 4-isopropyl-1,3-cyclohexadienemethanol; 4-isopropyl-1,3-cyclohexadienoic acid; p-cymene; cumic alcohol; cumic acid; intestinal bacteria

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Quantitative TLC Determination of Epimeric Ratios of 16-Methyl 17-Ketone Oxidation Products of Dexamethasone and Related Drugs

Cited by 5 publications

References 17 publications

A validated, stability-indicating method for the assay of dexamethasone in drug substance and drug product analyses, and the assay of preservatives in drug product

A validated, stability-indicating method for the assay of dexamethasone in drug substance and drug product analyses, and the assay of preservatives in drug product

Application of polarography and voltammetry to drug analysis in industry

Biotransformation of α-Terpinene in Common Cutworm Larvae (Spodoptera lituraFabricius)

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