Quantitative Topographic Curvature Maps of the Posterior Eye Utilizing Optical Coherence Tomography

McNabb, Ryan P.; Liu, Alice; Gospe, Sidney M.; El-Dairi, Mays; Meekins, Landon C.; James, Charlene; Vann, Robin; Izatt, Joseph A.; Kuo, Anthony N.

doi:10.1097/iae.0000000000002897

Cited by 5 publications

(1 citation statement)

References 20 publications

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“…Some previous studies have attempted to correct these distortions [18][19][20][21][22][23]. McNabb et al correct distortions using a "whole-eye" OCT system, and successfully generated quantitative curvature maps with intersession repeatability [24,25]. While simultaneous acquisition of the anterior and posterior segments of the eye using whole-eye OCT enables more accurate distortion correction, the device is not commercially available.…”

Section: Introductionmentioning

confidence: 99%

New findings on the unique curvature region in the posterior eye using widefield OCT

Hiraoka,

Tamura,

Moriguchi

et al. 2024

Preprint

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This study aimed to explore the curvature distribution in the posterior eye among school-aged children using distortion-corrected optical coherence tomography (OCT) images and its relationship with biometric variables and choroidal vascular parameters. We conducted a prospective, observational, cross-sectional study involving 88 children aged 6 to 15 years. After comprehensive ocular examinations, widefield OCT volumes with a 68×68 degrees were captured utilizing a high-speed, wide-field SS-OCT prototype system. The distortion of the captured OCT volume was geometricallycorrected, and Gaussian curvature maps were derived from Bruch’s membrane segmentation lines. The mean curvature was assessed across four square regions of 19×19 degrees each, where axial length (AL), refractive error, age, and choroidal thickness (ChT) were statistically analyzed. Additionally, the entry site of the long posterior ciliary artery (LPCA) into the choroid were assessed from the same OCT volume. Analysis of 169 OCT images demonstrated bilateral symmetry in choroidal vascular patterns and posterior eye curvature. Mean curvature exhibited asignificant correlation with AL, refractive error, and ChT in the superior, macular, and inferior regions. Conversely, the temporal region showed a weak negative correlation. Notably, a local maximum curvature point was commonly observed in the temporal region for the first time in this study, suggesting a potential reversal of correlation in this area. The rationale for this observation remains unclear; however, the proximity of the local maximum curvature point to the long posterior ciliary artery (LPCA) entry site may suggest a link. Further investigation is necessary to elucidate the origins and implications of these findingsfor ocular development.

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Section: Introductionmentioning

confidence: 99%

New findings on the unique curvature region in the posterior eye using widefield OCT

Hiraoka,

Tamura,

Moriguchi

et al. 2024

Preprint

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Automated Classification and Detection of Staphyloma with Ultrasound Images in Pathologic Myopia Eyes

Ito¹,

Lye²,

Dan³

et al. 2022

Ultrasound in Medicine & Biology

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Critical Impact of Working Distance on OCT Imaging: Correction of Optical Distortion and Its Effects on Measuring Retinal Curvature

Kim,

Sharpe,

Siber

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Purpose To assess the impact of working distance (WD) on optical distortion in optical coherence tomography (OCT) imaging and to evaluate the effectiveness of optical distortion correction in achieving consistent retinal Bruch's membrane (BM) layer curvature, regardless of variations in WD. Methods Ten subjects underwent OCT imaging with four serial macular volume scans, each employing distinct WD settings adjusted by balancing the sample and reference arm of the OCT interferometer (eye length settings changed). Either of two types of 30° standard objectives (SOs) was used. A ray tracing model was used to correct optical distortion, and BM layer curvature (represented as the second derivative of the curve) was measured. Linear mixed effects (LME) modeling was used to analyze factors associated with BM layer curvature, both before and after distortion correction. Results WD exhibited significant associations with axial length (β = −1.35, P < 0.001), SO type ( P < 0.001), and eye length settings ( P < 0.001). After optical distortion correction, the mean ± SD BM layer curvature significantly increased from 16.80 ± 10.08 µm –1 to 49.31 ± 7.50 µm –1 ( P < 0.001). The LME model showed a significant positive association between BM layer curvature and WD (β = 1.94, P < 0.001). After distortion correction, the percentage change in BM layer curvature due to a 1-mm WD alteration decreased from 9.75% to 0.25%. Conclusions Correcting optical distortion in OCT imaging significantly mitigates the influence of WD on BM layer curvature, enabling a more accurate analysis of posterior eye morphology, especially when variations in WD are unavoidable.

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Quantitative Topographic Curvature Maps of the Posterior Eye Utilizing Optical Coherence Tomography

Cited by 5 publications

References 20 publications

New findings on the unique curvature region in the posterior eye using widefield OCT

New findings on the unique curvature region in the posterior eye using widefield OCT

Automated Classification and Detection of Staphyloma with Ultrasound Images in Pathologic Myopia Eyes

Critical Impact of Working Distance on OCT Imaging: Correction of Optical Distortion and Its Effects on Measuring Retinal Curvature

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