Quantitative trait locus mapping of resistance to Aspergillus flavus infection using a recombinant inbred line population in maize

Yin, Zhitong; Wang, Yanqiu; Wu, Feifei; Gu, Xiao Hui; Bian, Yunlong; Wang, Yijun; Deng, Dexiang

doi:10.1007/s11032-013-9932-y

Cited by 26 publications

(27 citation statements)

References 37 publications

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“…Among Z. mays genes, several ROS genes were found to have the largest number of connections in the network. For example, the Z. mays glutathione S -transferase 7 (GST7), which has been previously implicated in ROS (Mideros et al, 2014; Yin et al, 2014; Fountain et al, 2015), had 776 connections, while cytochrome P450 family 72 (GRMZM2G147752), also involved in oxidative stress, had 223 connections in the interspecies network. Interestingly, the top 20 most connected genes in the network were A. flavus genes ( Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

et al. 2016

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A gene co-expression network (GEN) was generated using a dual RNA-seq study with the fungal pathogen Aspergillus flavus and its plant host Zea mays during the initial 3 days of infection. The analysis deciphered novel pathways and mapped genes of interest in both organisms during the infection. This network revealed a high degree of connectivity in many of the previously recognized pathways in Z. mays such as jasmonic acid, ethylene, and reactive oxygen species (ROS). For the pathogen A. flavus, a link between aflatoxin production and vesicular transport was identified within the network. There was significant interspecies correlation of expression between Z. mays and A. flavus for a subset of 104 Z. mays, and 1942 A. flavus genes. This resulted in an interspecies subnetwork enriched in multiple Z. mays genes involved in the production of ROS. In addition to the ROS from Z. mays, there was enrichment in the vesicular transport pathways and the aflatoxin pathway for A. flavus. Included in these genes, a key aflatoxin cluster regulator, AflS, was found to be co-regulated with multiple Z. mays ROS producing genes within the network, suggesting AflS may be monitoring host ROS levels. The entire GEN for both host and pathogen, and the subset of interspecies correlations, is presented as a tool for hypothesis generation and discovery for events in the early stages of fungal infection of Z. mays by A. flavus.

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Section: Resultsmentioning

confidence: 99%

A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

et al. 2016

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“…Eight QTL mapping experiments on A. flavus or aflatoxin resistance [35][36][37][38][39][40][41][42] and one additional on ear rot due to A. flavus [43] have been published to date. Most of these QTL studies have reported multiple QTL, most of which have been found in only one environment, and the majority of the QTL each account for less than 5% of the phenotypic variation observed in the population and the environment in which it was measured.…”

Section: Mapped Aflatoxin Resistance Qtlmentioning

confidence: 99%

Aflatoxin Resistance in Maize: What Have We Learned Lately?

Warburton

Williams

2014

Advances in Botany

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Aflatoxin contamination of maize grain is a huge economic and health problem, causing death and increased disease burden in much of the developing world and income loss in the developed world. Despite the gravity of the problem, deployable solutions are still being sought. In the past 15 years, much progress has been made in creating resistant maize inbred lines; mapping of genetic factors associated with resistance; and identifying possible resistance mechanisms. This review highlights this progress, most of which has occurred since the last time a review was published on this topic. Many of the needs highlighted in the last reviews have been addressed, and several solutions, taken together, can now greatly reduce the aflatoxin problem in maize grain. Continued research will soon lead to further solutions, which promise to further reduce and even eliminate the problem completely.

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“…By analyzing phenotypic data from three locations, they were able to identify two consistent QTLs, one with a PVE of 7-18%, and a second with a PVE of 8-18%, indicating a nominal degree of variation between the environments. In another study, a single consistent QTL (PVE 8.42%) was identified using a recombinant inbred line (RIL) population of 228F 8:9 RILs derived from RA × M53 (resistant × susceptible) utilizing 916 SNP markers for linkage map construction, and phenotyping data was obtained from two locations with contrasting environments for phenotypic analysis [61].…”

Section: Qtl Discoverymentioning

confidence: 99%

Resistance to Aspergillus flavus in maize and peanut: Molecular biology, breeding, environmental stress, and future perspectives

et al. 2015

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The colonization of maize (Zea mays L.) and peanut (Arachis hypogaea L.) by the fungal pathogen Aspergillus flavus results in the contamination of kernels with carcinogenic mycotoxins known as aflatoxins leading to economic losses and potential health threats to humans. The regulation of aflatoxin biosynthesis in various Aspergillus spp. has been extensively studied, and has been shown to be related to oxidative stress responses. Given that environmental stresses such as drought and heat stress result in the accumulation of reactive oxygen species (ROS) within host plant tissues, host-derived ROS may play an important role in cross-kingdom communication between host plants and A. flavus. Recent technological advances in plant breeding have provided the tools necessary to study and apply knowledge derived from metabolomic, proteomic, and transcriptomic studies in the context of productive breeding populations. Here, we review the current understanding of the potential roles of environmental stress, ROS, and aflatoxin in the interaction between A.flavus and its host plants, and the current status in molecular breeding and marker discovery for resistance to A. flavus colonization and aflatoxin contamination in maize and peanut. We will also propose future directions and a working model for continuing research efforts linking environmental stress tolerance and aflatoxin contamination resistance in maize and peanut.

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Quantitative trait locus mapping of resistance to Aspergillus flavus infection using a recombinant inbred line population in maize

Cited by 26 publications

References 37 publications

A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

A Network Approach of Gene Co-expression in the Zea mays/Aspergillus flavus Pathosystem to Map Host/Pathogen Interaction Pathways

Aflatoxin Resistance in Maize: What Have We Learned Lately?

Resistance to Aspergillus flavus in maize and peanut: Molecular biology, breeding, environmental stress, and future perspectives

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