Quantitative translation of dog-to-human aging by conserved remodeling of epigenetic networks

Wang, Tina; Ma, Jianzhu; Hogan, Andrew N.; Fong, Samson; Licon, Katherine; Tsui, Brian; Kreisberg, Jason F.; Adams, Peter D.; Carvunis, Anne‐Ruxandra; Bannasch, Danika L.; Ostrander, Elaine A.; Ideker, Trey

doi:10.1101/829192

Cited by 5 publications

(2 citation statements)

References 53 publications

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“…In contrast, dogs fed vegan diets could be expected to have relatively worse health outcomes. Due to their shorter lifespans, a single canine year of life equates to many years of human life [ 38 ], from a veterinary healthcare perspective.…”

Section: Discussionmentioning

confidence: 99%

Vegan versus meat-based dog food: Guardian-reported indicators of health

Knight

Huang²,

Rai

et al. 2022

PLoS ONE

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Alternative pet foods may offer benefits concerning environmental sustainability and the welfare of animals processed into pet foods. However, some worry these may compromise the welfare of pets. We asked 2,639 dog guardians about one dog living with them, for at least one year. Among 2,596 involved in pet diet decision-making, pet health was a key factor when choosing diets. 2,536 provided information relating to a single dog, fed a conventional meat (1,370 = 54%), raw meat (830 = 33%) or vegan (336 = 13%) diet for at least one year. We examined seven general indicators of ill health: unusual numbers of veterinary visits, medication use, progression onto a therapeutic diet after initial maintenance on a vegan or meat-based diet, guardian opinion and predicted veterinary opinion of health status, percentage of unwell dogs and number of health disorders per unwell dog. Dogs fed conventional diets appeared to fare worse than those fed either of the other two diets. Dogs fed raw meat appeared to fare marginally better than those fed vegan diets. However, there were statistically significant differences in average ages. Dogs fed raw meat were younger, which has been demonstrated to be associated with improved health outcomes. Additionally, non-health related factors may have improved apparent outcomes for dogs fed raw meat, for three of seven general health indicators. We also considered the prevalence of 22 specific health disorders, based on predicted veterinary assessments. Percentages of dogs in each dietary group considered to have suffered from health disorders were 49% (conventional meat), 43% (raw meat) and 36% (vegan). Significant evidence indicates that raw meat diets are often associated with dietary hazards, including nutritional deficiencies and imbalances, and pathogens. Accordingly, the pooled evidence to date indicates that the healthiest and least hazardous dietary choices for dogs, are nutritionally sound vegan diets.

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Section: Discussionmentioning

confidence: 99%

Vegan versus meat-based dog food: Guardian-reported indicators of health

Knight

Huang²,

Rai

et al. 2022

PLoS ONE

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“…Adolescence a period to occur physical and emotional changes with rapid growth. Many human studies have suggested that the gut microbial composition in early life affects the immune system and health in the future [ 42 , 43 ]. Our results suggest that the management of GM during the growing period is also important in dogs.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Gut Microbiota of 96 Healthy Dogs by Individual Traits: Breed, Age, and Body Condition Score

You

Kim

2021

Animals

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Since dogs are part of many peoples’ lives, research and industry related to their health and longevity are becoming a rising topic. Although gut microbiota (GM) is a key contributor to host health, limited information is available for canines. Therefore, this study characterized GM according to individual signatures (e.g., breed, age, and body condition score—BCS) of dogs living in the same environment. Fresh fecal samples from 96 healthy dogs were analyzed by sequencing the V3-V4 region of the 16S rRNA gene. The major microbial phyla were Firmicutes, Bacteroidetes, Fusobacteria, Proteobacteria, and Actinobacteria. In the comparison by breeds, relative abundance of Fusobacterium was significantly differed. Interestingly, Fusobacterium perfoetens abundance was positively correlated with age (p = 0.018), being significantly more enriched in the 6–10-year-old group (14.3%) than in the 0.5–1-year-old group (7.2%). Moreover, despite the healthy appearance of dogs in all age (0.5–10 years) and BCS (3–6) groups, the gut microbial environment may be disadvantageous in older dogs or in dogs with an abnormal BCS. These findings broaden our understanding of gut microbial ecology according to individual characteristics of dogs and may be used as a reference for providing customized-care to companion animals.

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