Quantitative ultrasonometry for the diagnosis of osteoporosis in human skeletal remains: New methods and standards

Rinaldo, Natascia; Pasini, Alba; Donati, Roberta; Belcastro, Maria Giovanna; Gualdi‐Russo, Emanuela

doi:10.1016/j.jas.2018.09.013

Cited by 10 publications

(21 citation statements)

References 66 publications

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“…QUS is not used to obtain images, but to measure and assess tissue properties (60). This modality may be used to evaluate osteoporosis (61,62) and fracture healing (63)(64)(65). QUS is a low-cost technique that has been applied at different anatomical sites, but according to the International Society for Clinical Densitometry (ISCD) official guideline (66) the only validated skeletal site is the calcaneus.…”

Section: Discussionmentioning

confidence: 99%

Ex vivo vibro-acoustography characterization of osteoporosis in an experimental mice model

Agnollitto¹,

Braz²,

Spirlandeli³

et al. 2021

Quant Imaging Med Surg

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Background: Osteoporosis is a highly prevalent multifactorial osteometabolic disease, classically diagnosed, in vivo, by dual energy X-ray absorptiometry (DXA). This study evaluated osteoporosis, ex vivo, using vibroacoustography (VA), an elastographic technique based on ultrasound radiation force.Methods: Three groups of mice femurs were used: (I) control group (CG), (II) osteoporosis group (OG) and (III) treated osteoporosis group (TOG), in which the animals received pamidronate, an antiresorptive drug. Evaluation was performed in an acoustic tank, using two high frequency focused beams produced by a confocal ultrasonic transducer. A hydrophone registered the low frequency acoustic response (AR) of bone samples. We used micro-computed tomography (microCT) as the reference standard and evaluated the correlation between VA and microCT parameters. Results:The spectral analyses of the ARs with estimated area under the curve (AUC) values (mean; st. dev.) were, respectively, 1.29e -07 and 9.32e -08 for the CG, 3.25e -08 and 2.16e -08 for the OG, and 1.50e -07 and 8.37e -08 for the TOG. VA differentiated the experimental groups (P<0.01) and the results were reproducible [interclass correlation coefficient (ICC): 0.43 (95% CI: 0.15-0.71)]. There was also a statistically significant association between VA and microCT connectivity (Conn.) (r=0.80; P<0.01) and connectivity density (Conn. D) (r=0.76; P<0.01).Conclusions: These results encourage further studies aimed at evaluating the potential use of VA for the diagnosis of osteoporosis as a relatively low-cost and radiation-free alternative to DXA.

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Section: Discussionmentioning

confidence: 99%

Ex vivo vibro-acoustography characterization of osteoporosis in an experimental mice model

Agnollitto¹,

Braz²,

Spirlandeli³

et al. 2021

Quant Imaging Med Surg

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“…Therefore, the BIF, more than any single biomarker, offers a comprehensive view of the frailty of each individual and can be used as a proxy for his or her pre-existing health status and, thus, for the risk of death. Stature was estimated from long bone measurements (Gualdi-Russo et al 2018;Pearson 1899;Trotter and Gleser 1958), whereas osteoporosis was evaluated through quantitative ultrasonometry (Rinaldo et al 2018). Each biomarker was considered as a categorical variable, assigning a score of 1 if present and 0 if absent.…”

Section: Methodsmentioning

confidence: 99%

Overall frailty gauged in victims of the Italian plague (Imola, 1630–1632): was plague an indiscriminate killer?

Zedda

Rinaldo

Gualdi‐Russo

et al. 2022

Archaeol Anthropol Sci

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Plague is an epidemic-prone infectious disease that has affected humanity with catastrophic effects throughout almost its entire history. One of the most intriguing questions of the last years is whether plague kills indiscriminately. To address the question regarding pre-existent health conditions, this study aims to assess the overall frailty of plague victims and compare it with a sample of non-plague victims from the same period and area. Frailty was assessed using the biological index of frailty (BIF) on two skeletal series dated to the seventeenth century from north-eastern Italy: one of plague victims from the Imola’s Lazzaretto (n = 93) and another from an attritional cemetery located in Ravenna (n = 58). Comparisons between the BIF values of the two samples were performed separately by sex and age classes. Cox proportional hazards regression was conducted to analyze factors associated with the risk of dying from plague. The age-adjusted ANCOVA test revealed no significant differences in BIF results between the two samples. However, according to Cox’s regression, individuals in the lowest BIF category (the least frail) had a significantly higher hazard of dying from plague. Although we found no differences between the mean frailty values of plague and non-plague victims in the univariate analysis, individuals with a low level of frailty showed a higher hazard of dying from plague than from other causes. In fact, otherwise healthier individuals (i.e., with low levels of frailty) could be found only among plague victims.

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“…The latter include methodological studies focused on estimation of age-at-death and attribution of sex [47][48][49][50][51][52][53][54][55][56][57][58][59][60][61], the study of entheseal changes in modern humans [62][63][64][65][66][67], and the discussion of their variability among extinct taxa [1][2][3][4]. Additional topics of investigation have been the various expression and demographic distribution of skeletal morphological variants and pathological changes [68][69][70][71], as well as dental and palate traits [72][73][74][75][76]. These collections have also offered excellent biological, demographic, and biocultural background in the analysis and discussion of case studies [77][78][79].…”

Section: Scientific Osteological Collections and Their Utilitymentioning

confidence: 99%

Scientific and Ethical Aspects of Identified Skeletal Series: The Case of the Documented Human Osteological Collections of the University of Bologna (Northern Italy)

et al. 2022

Self Cite

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Osteological collections are an essential source of information on human biological and cultural variability, providing insights about developmental, evolutionary, and biocultural processes. Among osteological series, documented human osteological collections (DHOC) are especially useful due to the opportunity to control biological parameters such as age-at-death and sex, which are typically unknown in archaeological or forensic cases. Raising ethical concerns about the collection, management, and study of human remains poses anthropologists with renewed responsibilities. These issues become especially pressing when dealing with DHOC. In this contribution, we discuss the scientific value and ethical issues characterizing DHOC using as case study the documented human osteological collections of the University of Bologna. This series includes more than 1000 individuals from Northern Italian and Sardinian cemeteries and is among the largest in Europe. It represents the basis for ongoing research on a large range of methodological studies, especially focused on the reconstruction of biological profile. After outlining the scientific studies performed on this DHOC, we discuss it in the context of the specific legislation featuring the Italian territory. Finally, we highlight some directions where work can be carried out to better balance scientific research, preservation needs, and ethical concerns, stressing the advantages of modern imaging techniques.

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Quantitative ultrasonometry for the diagnosis of osteoporosis in human skeletal remains: New methods and standards

Cited by 10 publications

References 66 publications

Ex vivo vibro-acoustography characterization of osteoporosis in an experimental mice model

Ex vivo vibro-acoustography characterization of osteoporosis in an experimental mice model

Overall frailty gauged in victims of the Italian plague (Imola, 1630–1632): was plague an indiscriminate killer?

Scientific and Ethical Aspects of Identified Skeletal Series: The Case of the Documented Human Osteological Collections of the University of Bologna (Northern Italy)

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