Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom

Devaux, Christiane; Jouirou, Besma; Krifi, Mohamed Naceur; Clot-Faybesse, Olivier; Ayeb, Mohamed El; Rochat, Hervé

doi:10.1016/j.toxicon.2004.02.021

Cited by 38 publications

(28 citation statements)

References 37 publications

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“…No significant variability of clinical and laboratory profiles according to the studied parameters was found ( Table 2). The undefined scorpion species, the patients' body weight, and the individual differences, as well as previous treatments, are important factors implicated in the vulnerability to envenomation (5,12,13). An increase in mean arterial pressure, heart rate, glucose level and number of white blood cells was observed in scorpion-envenomed pregnant women compared with the nonpregnant ones.…”

Section: Resultsmentioning

confidence: 99%

Scorpion envenomation symptoms in pregnant women

Ben-Nasr¹,

Hammami²,

Z³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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Scorpion envenomation is common in many countries; however, its effects on pregnancy are still unclear. In the present paper, we described the effects of scorpion envenomation on pregnant patients. A retrospective study was carried out considering the clinical and laboratory exams of patients admitted to the emergency room of Habib Bourguiba Hospital, Sfax, Tunisia, from 1990 to 2004. Variability of these clinical and laboratory profiles according to maternal age, gestational age and number of previous parities was also discussed. Among 167 scorpion-envenomed women, age ranged from 17 to 42 years, 7.18% were pregnant. These presented symptoms similar to those of non-pregnant women envenomed by scorpions. Two pregnant patients developed intense pelvic pain and one manifested vaginal bleeding. Although the studied parameters showed non-significant differences, we could conclude that scorpion envenomation may lead to abnormal uterine contraction probably causing preterm delivery. Maternal disturbances induced by scorpion envenomation may influence the fetus development. The effects were more severe in the second trimester of pregnancy.KEY WORDS: pregnant women, scorpion envenomations, signs and symptoms, laboratory data.

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Section: Resultsmentioning

confidence: 99%

Scorpion envenomation symptoms in pregnant women

Ben-Nasr¹,

Hammami²,

Z³

et al. 2007

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Les accidents provoqués par les piqûres de scorpions sont fréquents dans certains pays, en particulier, en Amérique Centrale, en Amérique du Sud, en Afrique du Nord, au Moyen Orient et en Inde [1,2].…”

Section: Introductionunclassified

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

et al. 2009

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Résumé - Mots clés : Envenimation, scorpion, épidémiologie, fiches d'hospitalisation, Beni MellalAbstract -In Morocco, the province of Beni Mellal is one of the regions most affected by the problem of scorpion sting and envenomation. Objective: The aim of this research is to reduce cases of morbidity and mortality subsequent to scorpion envenomation through the analysis and interpretation of data recorded in hospital admission forms. Patients and methods: Our study covered 56 retrospective cases of scorpion poisoning during the year 2007, which were reported by the hospital's intensive care service in Beni Mellal province. Results: Results indicate that scorpion envenomation occurs mainly during summer time, in particular during June and July. Moreover, stings happen at night between 6PM and 6AM (56.8%). Youngsters with age less than or equal to 15 years are those most exposed to envenomation, with a male age of 14.92 ± 12.94 years. Furthermore, 71.4% of the hurt patients arrive at the hospital with general symptoms and 28.6% exhibit signs of vital distress. The therapy is still variable, and the rate of lethality at hospital is 8.92%. Statistical analysis of various factors studied in relation to survival prediction (recovery and mortality) showed a highly significant difference for each admission class (χ 2 = 13.72 and p < 0.001). Age of less than 15 years and cardiovascular are factors of risk for envenomed patients. Conclusion: Scorpion envenomation remains a public health problem in Morocco.

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“…AahI was measured using the 2G3 mAb as a capture antibody and the biotinylated 9C2 mAb as a detecting antibody (31). AahII was measured using polyclonal IgG antiAahII and biotinylated 4C1 mAb (12).…”

Section: Methodsmentioning

confidence: 99%

“…The proportions of the three toxins differ in different venoms. The AahII toxin is the most abundant, followed by AahI, and then AahIII (12). AahII seems to be responsible for 70% of the toxicity and produces the greatest toxic effect, regardless of the route of injection (intracerebroventricular or subcutaneous (s.c.)) in mice.…”

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confidence: 99%

Diabody Mixture Providing Full Protection against Experimental Scorpion Envenoming with Crude Androctonus australis Venom

Tommaso

Juste

Martin‐Eauclaire

et al. 2012

Journal of Biological Chemistry

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Background: Currently, the only known treatment for scorpion envenomation is serotherapy with a heterologous polyclonal antibody displaying low specificity. Results: The injection of a diabody mixture allowed mice to survive in a test that mimics severe envenomation with the crude venom. Conclusion:The diabody mixture displayed better protective power than any other known remedy. Significance: This could herald the next generation of antivenoms.

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Quantitative variability in the biodistribution and in toxinokinetic studies of the three main alpha toxins from the Androctonus australis hector scorpion venom

Cited by 38 publications

References 37 publications

Scorpion envenomation symptoms in pregnant women

Scorpion envenomation symptoms in pregnant women

Les caractéristiques épidémiologiques et cliniques des envenimations scorpioniques dans la province de Beni Mellal (Maroc)

Diabody Mixture Providing Full Protection against Experimental Scorpion Envenoming with Crude Androctonus australis Venom

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