Quantum chemical study of 2-hydroxypropyl-β-cyclodextrin and genipin-crosslinked chitosan nanocarriers functionalized with cytarabine anticancer drug

Rezaei, Azadeh; Vahidi, S. Hooman; Nasrabadi, Marjan; Beyramabadi, S. Ali; Morsali, Ali

doi:10.1016/j.molliq.2022.120427

Cited by 8 publications

(4 citation statements)

References 65 publications

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“…More compact microstructures and improved mechanical properties of the chitosan hydrogel are reported by the use of succinic acid and urea, in addition to chemical crosslinking, in the presence of genipin [ 121 ]. Therefore, several studies have reported the utilization of the genipin-crosslinked chitosan for anti-bacterial material [ 122 ], as a carrier of drugs including 5-fluorouracil [ 123 ], cisplatin [ 124 ], and cytarabine [ 125 ], as well as for the treatment of diabetes [ 126 ] and diabetic wounds [ 127 ]. However, the drawback of using genipin as a crosslinker is relatively long gelation time [ 128 ].…”

Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

“…Chitosan hydrogels have shown potential as targeted drug delivery systems in cancer treatment. By incorporating anti-cancer drugs, such as 5-fluorouracil [ 123 , 184 ], cisplatin [ 124 ], cytarabine [ 125 ], doxorubicin [ 18 , 87 ], and methotrexate [ 185 ], into the hydrogels, the drugs can be delivered directly to cancer cells. The hydrogels can be formulated into various shapes and sizes, such as nanoparticles or microspheres, to enhance the delivery efficiency and reduce the risk of systemic toxicity.…”

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

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Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

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Chitosan is a promising naturally derived polysaccharide to be used in hydrogel forms for pharmaceutical and biomedical applications. The multifunctional chitosan-based hydrogels have attractive properties such as the ability to encapsulate, carry, and release the drug, biocompatibility, biodegradability, and non-immunogenicity. In this review, the advanced functions of the chitosan-based hydrogels are summarized, with emphasis on fabrications and resultant properties reported in literature from the recent decade. The recent progress in the applications of drug delivery, tissue engineering, disease treatments, and biosensors are reviewed. Current challenges and future development direction of the chitosan-based hydrogels for pharmaceutical and biomedical applications are prospected.

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Section: Gelation Techniques Of Chitosan-based Hydrogelsmentioning

confidence: 99%

Section: Pharmaceutical and Biomedical Applications Of Chitosan-based...mentioning

confidence: 99%

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Taokaew

Kaewkong

Kriangkrai

2023

Gels

View full text Add to dashboard Cite

show abstract

“…Chitosan hydrogels can be used as cancer therapy tools to deliver specific drugs. The hydrogels can be used to deliver anticancer medications such as cytarabine [146], methotrexate [147], 5-fluorouracil [148,149], doxorubicin [150,151], and cisplatin [152] directly to cancer cells. Li et al created a thiolated chitosan hydrogel with a gelation point of 37 • C to target and treat a solid tumor.…”

Section: Utilization Of Chitosan-based Products In Drug Deliverymentioning

confidence: 99%

Chitosan-Based Composites: Development and Perspective in Food Preservation and Biomedical Applications

Kumar

Yadav

Pramanik³

et al. 2023

Polymers

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Chitin, which may be the second-most common polymer after cellulose, is the raw material of chitosan. Chitosan has been infused with various plant extracts and subsidiary polymers to improve its biological and physiological properties. Chitosan’s physicochemical properties are enhanced by blending, making them potential candidates that can be utilized in multifunctional areas, including food processing, nutraceuticals, food quality monitoring, food packaging, and storage. Chitosan-based biomaterials are biocompatible, biodegradable, low toxic, mucoadhesive, and regulate chemical release. Therefore, they are used in the biomedical field. The present manuscript highlights the application of chitosan-based composites in the food and biomedical industries.

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“…However, most studies − in this research domain use complex nanosystems, thereby hindering the scalability and translation to clinical research. Recently, a few DNA nanosystems to deliver drugs like doxorubicin in cancer therapeutics , have been proposed. Doxorubicin disrupts DNA replication and protein synthesis due to intercalation within the DNA ladder .…”

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confidence: 99%

High-Affinity DNA Nanomatrix: A Platform Technology for Synergistic Drug Delivery and Photothermal Therapy

et al. 2023

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With the advent of nucleosome/nucleotide intercalating drugs, DNA-based nanocarriers have recently gained impetus. However, most of the newly proposed DNA nanosystems are rather complex, thereby having low scalability and translatability. In this study, we propose a simple DNA nanomatrix core encapsulated within a chitosan shell, which is expected to enhance the encapsulation efficiency of intercalating drugs. This has been demonstrated using proflavine hemisulfate (PfHS), a model intercalating agent that shows improved ROS generation, among other anticancerous properties. The release of the drug from the nanomatrix is triggered by providing a heat trigger using IR-792 perchlorate, a known NIR photothermal sensitizer.

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Quantum chemical study of 2-hydroxypropyl-β-cyclodextrin and genipin-crosslinked chitosan nanocarriers functionalized with cytarabine anticancer drug

Cited by 8 publications

References 65 publications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Recent Development of Functional Chitosan-Based Hydrogels for Pharmaceutical and Biomedical Applications

Chitosan-Based Composites: Development and Perspective in Food Preservation and Biomedical Applications

High-Affinity DNA Nanomatrix: A Platform Technology for Synergistic Drug Delivery and Photothermal Therapy

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