2015
DOI: 10.1063/1.4921203
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Quantum dot-based microfluidic biosensor for cancer detection

Abstract: We report results of the studies relating to fabrication of an impedimetric microfluidic–based nucleic acid sensor for quantification of DNA sequences specific to chronic myelogenous leukemia (CML). The sensor chip is prepared by patterning an indium–tin–oxide (ITO) coated glass substrate via wet chemical etching method followed by sealing with polydimethylsiloxane (PDMS) microchannel for fluid control. The fabricated microfluidic chip comprising of a patterned ITO substrate is modified by depositing cadmium s… Show more

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Cited by 29 publications
(15 citation statements)
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“…The probe was fabricated to detect change in concentration via interfacial charge transfer resistance after hybridization. The biosensor exhibited improved linearity in the concentration range of 10 -15 -10 -11 M DNA [15].…”
Section: Quantum-dots Based Sensormentioning
confidence: 99%
“…The probe was fabricated to detect change in concentration via interfacial charge transfer resistance after hybridization. The biosensor exhibited improved linearity in the concentration range of 10 -15 -10 -11 M DNA [15].…”
Section: Quantum-dots Based Sensormentioning
confidence: 99%
“…1.4.3A). In this microfluidic sensor, the cadmium selenide quantum dots were deposited on a patterned conductive electrode via the LangmuireBlodgett technique for detection of the target complementary DNA concentration by measuring the interfacial charge transfer resistance (R ct ) via hybridization [52]. Increasing concentrations of complementary DNA followed by DNA hybridization can result in the double-stranded DNA helix formation on the sensor surface that increases the negative charge of the electrode surface and hence decreasing R ct (Fig.…”
Section: Constant Phase Elementmentioning
confidence: 99%
“…n FIGURE 1.4.3 (A) The fabrication of microfluidic biochip for electrochemical detection of DNA hybridization using quantum dots and (B) the electrochemical impedance spectroscopy response spectra by varying the complementary DNA from 10 À15 to 10 À6 [52]. pcDNA, probe complementary DNA.…”
Section: Constant Phase Elementmentioning
confidence: 99%
“…One such example in cellomics is the use of fluorescent stains and organic dyes in droplet microfluidic devices to sort cells based on their dynamic fluorescent responses to external stimuli [12, 13]. Similarly, fluorescent proteins, quantum dots, and luminescent nanoparticles have been used to track protein-protein interactions, intracellular enzyme activities, and identify biomolecules or biomarkers within single cells encapsulated in droplets [1417]. In addition to cellomics, massively parallelized high-throughput droplet generators are used in combination with fluorescent barcodes to perform single cell DNA- and RNA- sequencing [18, 19].…”
Section: Introductionmentioning
confidence: 99%