Quantum dots decorated gold nanorod as fluorescent-plasmonic dual-modal contrasts agent for cancer imaging

Wu, Qiong; Chen, Lu; Huang, Liang; Wang, Jing; Liu, Jiawei; Hu, Chao; Han, Heyou

doi:10.1016/j.bios.2015.06.010

Cited by 50 publications

(25 citation statements)

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“…Nevertheless, here they [ 42 , 43 ] prove that this process of ‘atomization’ ( Figure 6 B) contributes to stable NHC@Au nanorods under a wide variety of harsh conditions, as well as those where conventional NHC and thiol@Au nanorods are unstable. In addition, assays to culture in vitro cells indicate that NHC@Au nanorods are promising materials for laser-induced Partial thromboplastin time (PTT).…”

Section: Gnr Synthesismentioning

confidence: 81%

Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity

et al. 2021

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Multifunctional gold nanorods (GNR) have drawn growing interest in biomedical fields because of their excellent biocompatibility, ease of alteration, and special optical properties. The great advantage of using GNR in medicine is their application to Photothermal therapy (PPTT), which is possible thanks to their ability to turn luminous energy into heat to cause cellular hyperthermia. For this purpose, the relevant articles between 1988 and 2020 were searched in databases such as John Wiley, Free paper, Scopus, Science Direct, and Springer to obtain the latest findings on multifunctional gold nanorods for therapeutic applications and pharmaceutical delivery. In this article, we review recent progress in diagnostic and therapeutic applications of multifunctional GNR, highlighting new information about their toxicity to various cellular categories, oxidative stress, cellular longevity, and their metabolic effects, such as the effect on the energy cycles and genetic structures. The methods for the synthesis and functionalization of GNR were surveyed. This review includes new information about GNR toxicity to various cellular categories and their metabolic effects.

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Section: Gnr Synthesismentioning

confidence: 81%

Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity

et al. 2021

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“…QDs-decorated gold nanorods with silicon coating functionalized with transferrin have been taken up by A549 lung cancer cell line and demonstrated good potential as high contrast fluorescent/ plasmonic bimodal labels for fluorescence and dark-field cell imaging [70]. A highly sensitive electro-chemiluminescent assay based on double-quenching of graphene QDs by G-quadruplexhemin and gold nanoparticles for protein kinase A activity detection in serum samples and cell lysates with a detection limit down to 0.04 U/mL was designed by Liu et al [71], which might be potentially utilised both in experimental settings and clinical biochemistry diagnostics.…”

Section: Quantum Dots For In Vitro Biomedical Experimental Systemsmentioning

confidence: 99%

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

Volkov

2015

Biochemical and Biophysical Research Communications

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a b s t r a c tThe review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including "classical" semiconductor groups III-V and II-VI nanocrystals, along with more recently emerged carbon, silicon, gold and other types of nanoparticles falling into this class of nanomaterials due to their similar physical characteristics such as small size and associated quantum confinement effects. A diverse range of QDs applications in nanomedicine has been extensively summarised previously in numerous publications. Therefore, this review is not intended to provide an all-embracing survey of the well documented QDs uses, but is rather focused on the most recent emerging developments, concepts and outstanding unresolved problematic and sometimes controversial issues. Over 125 publications are overviewed and discussed here in the context of major nanomedicine domains, i.e. medical imaging, diagnostics, therapeutic applications and combination of them in multifunctional theranostic systems.© 2015 Elsevier Inc. All rights reserved. Quantum dots in nanomedicine: recent trendsWithin a steadily increasing database of diverse nanomaterials reported as suitable for applications in nanomedicine [1e10], quantum dots (QDs) deservedly occupy a special niche as nanoparticles with a unique track record full of high expectations, dramatic pitfalls and often controversial experimental evidence. From the early optimistic aspirations of them as breakthrough tools for multipurpose in vitro and in vivo applications [11e17], they have been subject to a period of partial relinquishment following the sombre realisation that in the original unmodified state QDs did not stand a chance to deserve a unanimous approval as imaging or drug delivery vehicles in humans, due to their intrinsic toxicity and lack of biodegradability perspective. The disappointingly low yield of exploitable outputs following the initial rounds of heavy investments in the field has also contributed to the overall decline in research productivity metrics. The analysis of the recent ten years' trends in publications number in this area related to the QDs medical applications in vivo in general (Fig. 1 A), as well as for imaging and diagnostics purposes (Fig. 1 B, C) according to Thomson Reuters Web of Science™ database clearly reflects such "cooling down" period after 2010 resulting in a significant reduction in the initially steady exponential growth of publication rates. This trend has been partially or completely reversed by 2014 and it is intriguing whether we will see it sustained in 2015 and beyond.Such returning enthusiasm has been reinvigorated by a number of objective tendencies in the related technological developments, including the arrival of innovative nanotechnology-enabled tools for diagnostic and ex vivo imaging applications [18,19], the arrival of new types of QDs of alternative nature offering the opportunities of r...

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“…been intensively studied as functional materials and used for protein detection and cell imaging [12]. SiNPs doped with dyes have also been prepared and investigated for fluorescence imaging and biosensors.…”

Section: Introductionmentioning

confidence: 99%

Methyl Parathion Degrading Enzyme‐based Nano‐hybrid Biosensor for Enhanced Methyl Parathion Recognition

Guo

Peng

et al. 2016

Electroanalysis

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Enzyme‐based electrochemical biosensors with sufficient sensing specificity are useful analytical tools for detection of biologically important substances in complicated systems. Here, we present the design of a nano‐hybrid biosensor for the specific and sensitive detection of methyl parathion (MP). The nano‐hybrid sensing film was prepared via the formation of Au nanoparticals (AuNPs) on silica nanoparticles (SiNPs), mixing with multiwall carbon nanotube (MWNTs) and subsequent immobilization of methyl parathion degrading enzyme (MPD). The fabrication procedure was characterized by scanning electron images, linear scan voltammetry and electrochemical impedance spectroscopy. The combined MPD exhibited high affinity to it substrate and thus a selective, sensitive, fast and cheap method for determination of MP, quantitatively was proposed. A significant synergistic effect of nano‐hybrid on the biosensor performance was observed in biosensing MP. The square wave voltammetric responses displayed well defined peaks, linearly proportional to the concentration of MP in the range from 0.001 to 5.0 μg/mL with a detection limit of 0.3 ng/mL. The proposed biosensor also showed good precision and reproducibility, acceptable stability and accuracy in garlic samples analysis. It provided a platform for the simple and fast construction of biosensors with good performance for the determination of enzyme‐specific electroactive species.

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Quantum dots decorated gold nanorod as fluorescent-plasmonic dual-modal contrasts agent for cancer imaging

Cited by 50 publications

References 43 publications

Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity

Multifunctional Gold Nanorod for Therapeutic Applications and Pharmaceutical Delivery Considering Cellular Metabolic Responses, Oxidative Stress and Cellular Longevity

Quantum dots in nanomedicine: recent trends, advances and unresolved issues

Methyl Parathion Degrading Enzyme‐based Nano‐hybrid Biosensor for Enhanced Methyl Parathion Recognition

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