Quantum dots, lighting up the research and development of nanomedicine

Wang, Yunqing; Chen, Lingxin

doi:10.1016/j.nano.2010.12.006

Cited by 249 publications

(121 citation statements)

References 147 publications

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“…Another imposing limitation is that synthesized QDs are not water-soluble. 19 The most commonly used passivators to make these QDs water-soluble are toxic. 20,21 Thus, imparting toxic linker-assisted water solubility does not address the real issue of QD toxicity.…”

Section: Preparation Of Bare Cds and Silica-coated Cdsmentioning

confidence: 99%

Synthesis and application of luminescent single CdS quantum dot encapsulated silica nanoparticles directed for precision optical bioimaging

Veeranarayanan¹,

Poulose²,

Mohamed³

et al. 2012

IJN

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This paper presents the synthesis of aqueous cadmium sulfide (CdS) quantum dots (QDs) and silica-encapsulated CdS QDs by reverse microemulsion method and utilized as targeted bio-optical probes. We report the role of CdS as an efficient cell tag with fluorescence on par with previously documented cadmium telluride and cadmium selenide QDs, which have been considered to impart high levels of toxicity. In this study, the toxicity of bare QDs was efficiently quenched by encapsulating them in a biocompatible coat of silica. The toxicity profile and uptake of bare CdS QDs and silica-coated QDs, along with the CD31-labeled, silica-coated CdS QDs on human umbilical vein endothelial cells and glioma cells, were investigated. The effect of size, along with the time-dependent cellular uptake of the nanomaterials, has also been emphasized. Enhanced, high-specificity imaging toward endothelial cell lines in comparison with glioma cells was achieved with CD31 antibody-conjugated nanoparticles. The silica-coated nanomaterials exhibited excellent biocompatibility and greater photostability inside live cells, in addition to possessing an extended shelf life. In vivo biocompatibility and localization study of silica-coated CdS QDs in medaka fish embryos, following direct nanoparticle exposure for 24 hours, authenticated the nanomaterials' high potential for in vivo imaging, augmented with superior biocompatibility. As expected, CdS QD-treated embryos showed 100% mortality, whereas the silica-coated QD-treated embryos stayed viable and healthy throughout and after the experiments, devoid of any deformities. We provide highly cogent and convincing evidence for such silica-coated QDs as a model nanoparticle in practice, to achieve in vitro and in vivo precision targeted imaging.

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Section: Preparation Of Bare Cds and Silica-coated Cdsmentioning

confidence: 99%

Synthesis and application of luminescent single CdS quantum dot encapsulated silica nanoparticles directed for precision optical bioimaging

Veeranarayanan¹,

Poulose²,

Mohamed³

et al. 2012

IJN

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“…QDs coupled to materials with similar imaging and treatment function produce diverse biological functional probes that may be concurrently used for tumor molecular imaging and targeted therapy (13)(14)(15). Previous studies have assessed the feasibility of using QDs in cancer diagnosis, molecular classification, treatment and prognosis, and have established a broad prospect in basic and clinical cancer research (16,17).…”

Section: Introductionmentioning

confidence: 99%

Targeting breast cancer cells with a CuInS2/ZnS quantum dot-labeled Ki-67 bioprobe

et al. 2017

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Abstract. The aim of the present study was to develop a water-soluble biomarker for the detection of breast cancer using quantum dots (QDs) conjugated to Ki-67, a nuclear protein associated with the cell cycle. Ki-67 is also a marker of cell proliferation, with expression levels categorizing good and poor prognosis in invasive breast cancer. Ki-67 is a clinically used biomarker for breast cancer diagnosis, treatment and prognosis. Owing to the optical and chemical advantages of QDs, QD-based nanotechnology may aid the construction of a biomedical imaging platform for the study of cancer cell behavior. In the present study, a biomarker was prepared by employing the water-soluble CuInS 2 /ZnS QDs conjugated to an anti-Ki-67 monoclonal antibody to detect Ki-67 expression in breast cancer. The QDs, which were hydrophobic and coated with octadecylamine, were encapsulated with an amphiphilic biocompatible centipede-like polymer, and then conjugated to anti-Ki-67 monoclonal antibodies (QD-Ki-67 probes). The QD-Ki-67 probes retained the original optical properties of the unadorned QDs and did not exhibit distinct toxic side effects in in vitro cytotoxicity experiments. Therefore, this CuInS 2 /ZnS QD-labeled bioprobe, with a high quantum yield and low cytotoxicity, is a promising candidate for bioimaging and may be used as a cell label.

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“…3,4 QDs have several unique optical properties far superior to those of the organic chromophores. [5][6][7][8] For example, QDs have high molar extinction coefficients, broad absorption bands, high quantum efficiency (50%), narrow emission spectra with full width at half-maximum 50 nm, high resistance to photobleaching, and higher excited state lifetimes. 9,10 In addition to these features, it was demonstrated that QDs are at least 15 times brighter than organic dyes using the same excitation conditions.…”

Section: Introductionmentioning

confidence: 99%

Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots

Lin¹,

Wang²,

Yin³

et al. 2015

IJN

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In this paper, we demonstrate the preparation of monodispersed quantum dots (QDs) as near-infrared (NIR) optical probes for in vivo pancreatic cancer targeting and imaging. The design of these luminescent probes involves functionalizing NIR QDs with ligand mercaptosuccinic acid (MSA), which targets the tumor site by enhanced permeability and retention effect. The colloidal and optical stability of the QDs can be maintained for >1 week. In vivo optical imaging studies in nude mice bearing pancreatic tumor show that the probes accumulate at tumor sites for >2.5 hours following intravenous injection of the functionalized NIR QDs. Tumor-labeling studies showed no evidence of harmful effects on the treated animals, even at a dose as high a ~50 mg/kg. These results demonstrate that the engineered MSA-functionalized QDs can serve as a diagnostic platform for early detection of cancer, as well as in image-guided precise surgical resection of tumors.

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Quantum dots, lighting up the research and development of nanomedicine

Cited by 249 publications

References 147 publications

Synthesis and application of luminescent single CdS quantum dot encapsulated silica nanoparticles directed for precision optical bioimaging

Synthesis and application of luminescent single CdS quantum dot encapsulated silica nanoparticles directed for precision optical bioimaging

Targeting breast cancer cells with a CuInS2/ZnS quantum dot-labeled Ki-67 bioprobe

Passive tumor targeting and imaging by using mercaptosuccinic acid-coated near-infrared quantum dots

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