It is shown that in any von Neumann algebra with infinite‐dimensional non‐abelian central part there are always finite‐dimensional subalgebras which are C*‐independent but not W*‐independent. On the other hand, it is proved that C*‐independence is very close to W*‐independence in the following sense: If A and B are C*‐independent subalgebras of a von Neumann algebra M then the pairs (φ1,φ2), where φ1 is a normal state on A and φ2 is a normal state on B, which do admit a common normal extension over M form a norm dense set in the product of normal state spaces. Some other independence conditions (strict locality, logical independence) are studied.