Quantum Molecular Resonance–Assisted Phonomicrosurgery: Preliminary Experience

Demirhan, Erhan; Çukurova, İbrahim; Arslan, İlker Burak; Özkan, Elçin Tadıhan; Mengi, Erdem; Yigitbasi, Orhan

doi:10.1177/0194599814549729

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…It has been shown to positively affect wound healing and postoperative inflammation. 5,[10][11][12][13] QMR has been examined before in the context of DED. One previous study reported the capabilities of QMR in 27 patients with DED.…”

Section: Discussionmentioning

confidence: 99%

Quantum Molecular Resonance Effects on Patients With Dry Eye Disease: A Randomized Controlled Trial

Shemer,

Altarescu,

Nusbaum

et al. 2023

Cornea

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Purpose: The aim of the study was to evaluate the efficacy and safety of quantum molecular resonance in the treatment of dry eye disease. Methods: This study was a double-blind randomized control trial in 1 academic medical center, for 2 years. Participants received treatment or a placebo with the Rexon-Eye device, once per week for 4 weeks. The primary outcome was the change in dry eye symptoms assessed by the Ocular Surface Disease Index (OSDI). Secondary outcomes were clinical findings associated with the dry eye such as meibomian gland dysfunction (MGD) score, tear break-up time (TBUT), corneal fluorescein staining, Schirmer test, and best-corrected visual acuity (BCVA). Results: Forty patients were recruited, 20 in each arm. The mean age was 63.5 ± 15.1 years and 27 (67.5%) were female. The mean OSDI score significantly improved in the intervention group from 19.15 ± 10.3 to 10.5 ± 7.0 (P < 0.001), whereas the control group showed no significant change (14.4 ± 8.4 to 15.5 ± 8.6, P = 0.830). MGD scores significantly improved in the intervention group (1.57 ± 1.2 to 0.8 ± 0.9, P = 0.006), whereas showing no significant change in the control group (1.60 ± 0.9 to 1.99 ± 1.0, P = 0.244). The corneal staining score also showed significant improvement in the intervention group (P = 0.045) and a nonsignificant decline in the placebo group (P = 0.50). No significant difference was seen in TBUT, visual acuity, and Schirmer scores between groups. No harm resulting from treatment was reported during the duration of the trial. Conclusions: High-frequency electrotherapy may have a positive effect on symptoms and signs of dry eye. This emerging technology may become part of the arsenal of therapeutic modalities for this condition.

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Section: Discussionmentioning

confidence: 99%

Quantum Molecular Resonance Effects on Patients With Dry Eye Disease: A Randomized Controlled Trial

Shemer,

Altarescu,

Nusbaum

et al. 2023

Cornea

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“…The quantum molecular resonance (QMR) device is an innovative EBD that has been safely and effectively applied in o t o l a r y n g o l o g y -h e a d a n d n e c k s u r g e r i e s s u c h a s phonomicrosurgery (8), tonsillectomy (9)(10)(11), oral surgery (12), and adenoidectomy (13). QMR devices are powered using electron energy quanta, which is generated by alternate current and high-frequency electron waves, and it is characterized by a well-defined dominant wave at 4 MHz, followed by waves at 8, 12 and 16 MHz with reduced amplitude (13,14).…”

Section: Introductionmentioning

confidence: 99%

Safety Parameters of Quantum Molecular Resonance Devices During Thyroid Surgery: Porcine Model Using Continuous Neuromonitoring

et al. 2022

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ObjectivesQuantum molecular resonance (QMR) devices have been applied as energy-based devices in many head and neck surgeries; however, research on their use in thyroid surgery is lacking. This study aimed to investigate the safety parameters of QMR devices during thyroidectomy when dissection was adjacent to the recurrent laryngeal nerve (RLN).MethodsThis study included eight piglets with 16 RLNs, and real-time electromyography (EMG) signals were obtained from continuous intraoperative neuromonitoring (C-IONM). QMR bipolar scissor (BS) and monopolar unit (MU) were tested for safety parameters. In the activation study, QMR devices were activated at varying distances from the RLN. In the cooling study, QMR devices were cooled for varying time intervals, with or without muscle touch maneuver (MTM) before contacting with the RLN.ResultsIn the activation study, no adverse EMG change occurred when QMR BS and MU were activated at distances of 2 mm or longer from the RLNs. In the cooling study, no adverse EMG change occurred when QMR BS and MU were cooled in 2-second intervals or immediately after MTM.ConclusionQMR devices should be carefully used when performing RLN dissection during thyroid surgery. According to the activation and cooling safety parameters in this study, surgeons can avoid RLN injury by following standard procedures when using QMR devices.

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“…The use of low-temperature electrosurgery units (LTEU) avoids the formation of soot particles. In the case of LTEU, the increase in tissue temperature does not exceed 45 °C for the cut-off mode (unmodulated radiation) and 65 °C for the coagulation regimen [27,28]. This is dramatically different with low-frequency methods and essentially reduces the carbonization of the tissues to zero.…”

Section: Introductionmentioning

confidence: 99%

Combination of Low-Temperature Electrosurgical Unit and Extractive Electrospray Ionization Mass Spectrometry for Molecular Profiling and Classification of Tissues

et al. 2019

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Real-time molecular navigation of tissue surgeries is an important goal at present. Combination of electrosurgical units and mass spectrometry (MS) to perform accurate molecular visualization of biological tissues has been pursued by many research groups. Determination of molecular tissue composition at a particular location by surgical smoke analysis is now of increasing interest for clinical use. However, molecular analysis of surgical smoke is commonly lacking molecular specificity and is associated with significant carbonization and chemical contamination, which are mainly related to the high temperature of smoke at which many molecules become unstable. Unlike traditional electrosurgical tools, low-temperature electrosurgical units allow tissue dissection without substantial heating. Here, we show that low-temperature electrosurgical units can be used for desorption of molecules from biological tissues without thermal degradation. The use of extractive electrospray ionization technique for the ionization of desorbed molecules allowed us to obtain mass spectra of healthy and pathological tissues with high degree of differentiation. Overall, the data indicate that the described approach has potential for intraoperative use.

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Quantum Molecular Resonance–Assisted Phonomicrosurgery: Preliminary Experience

Cited by 4 publications

References 6 publications

Quantum Molecular Resonance Effects on Patients With Dry Eye Disease: A Randomized Controlled Trial

Quantum Molecular Resonance Effects on Patients With Dry Eye Disease: A Randomized Controlled Trial

Safety Parameters of Quantum Molecular Resonance Devices During Thyroid Surgery: Porcine Model Using Continuous Neuromonitoring

Combination of Low-Temperature Electrosurgical Unit and Extractive Electrospray Ionization Mass Spectrometry for Molecular Profiling and Classification of Tissues

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