Quantum molecular resonance technology in hard‐to‐heal extremity wounds: histological and clinical results

Abstract

Chronic wounds are commonly associated with high morbidity rates due to the patient's need of frequent dressing changes and repeated visits to the outpatient wound clinic. Furthermore, chronic wounds are often characterised by severe pain, which can cause significant disability to the patient. New technologies aim to develop an optimal device to reduce discomfort of the patient and to heal wounds. The device Rexon-age is introduced for the first time in wound healing, and preliminary data on clinical and histological results are shown. From April 2014 to April 2015, 11 patients - 7 females and 4 males - were enrolled in the present study. The study was conducted at the Plastic and Reconstructive Institute of the Università degli Studi di Torino, Città della Salute e della Scienza of Torino, Italy. For histological characterisation, pre- and post-treatment biopsies on the wound bed were performed. Data regarding age, gender, weight, height, comorbidity, drug therapy and topical pre-treatment and dressings of the wound were collected as well. Moreover, local factors regarding the wound data were as follows: aetiology, time of the wound formation until first Rexon-age treatment, wound dimensions, wound bed, moisture, margins and anatomical region of the wound. A visual analogue scale (VAS) was used to monitor the pain before and after each treatment. Rexon-age treatment resulted in improvement in granulation tissue and wound contraction. Moreover, a significant reduction of pain was observed with the reduction of painkillers drug usage. Among these Rexon-age-treated patients, three patients displayed 60-80% reduction in pain intensity, and two patients showed complete pain relief. In outpatient follow-up appointments, we registered long-term durability of pain relief. As assessed by histological analyses, post-treatment biopsies of all nine patients revealed a decreased amount of inflammatory cells and lower expression levels of metalloproteinases (e.g. MMP9). We observed increased capillary thrombosis as well as up-regulation of vascular endothelial growth factor (VEGF) expression. The current study presents the first evidence that Rexon-age-based therapy can significantly ameliorate and accelerate the healing process of chronic wounds. Although this study analysed only a small number of patients, we could consistently observe positive effects on both the clinical aspect of the lesions, which underwent size reduction and wound reactivation, and the quality of life of our patients due to long-term pain relief.

Use of quantum molecular resonance energy for managing postrhinoseptoplasty perilesional edema and ecchymosis

“…2 One histopathologic analysis was performed in patients with intractable chronic wounds on the extremities after QMR treatment, 1 wherein post-QMR skin specimens exhibited remarkable decreases in inflammatory cells, upregulated VEFG expression, and decreased matrix metalloproteinase expression, along with clinical improvement in the chronic wounds and significant reductions in wound-related pain. 1 In this study, all of our patients experienced shorter durations of postoperative edema and ecchymosis along the upper eyelids, followed by the lower eyelids and anterior cheeks, regardless of treatment group. Accordingly, the resolution of postoperative edema and ecchymosis seems to be topographically associated with the lymphatic drainage system at the face and neck.…”

“…2,3 In support thereof, QMR technology has been used clinically in patients to treat painful inflammatory musculoskeletal disorders of various origins, chronic intractable ulcerative wounds in the extremities, and postoperative edema after total knee arthroplasty. 1,6 Rhinoseptoplasty is a popular plastic surgical procedure of the face. [7][8][9][10] Revision rhinoseptoplasty is sometimes required in patients with a severely contracted nose resulting from excessive inflammatory reactions and fibrosis along nasal implants.…”

Novel quantum molecular resonance energy source for laparoscopic bipolar vessel sealer: An experimental study in animal model

“…Recently, researches on the molecular cell biological effects of QMR had been also conducted. Researchers reported the up-regulation of vascular endothelial growth factor expression in chronic wounds treated by QMR technology [10]. There was also a study that suggested the QMR stimulation could trigger angiogenesis and tissue regeneration of human mesenchymal stromal cells [11].…”

Dynamics of Regenerative Processes in Patients with Trophic Ulcers against the Background of Chronic Venous Hemodynamic Disturbances Using Therapy with Polydesoxyrinobonucleotides

“…(7) According to statistics, in industrialized countries, TUs lead to disability more often than tuberculosis, rheumatism and traffic injuries, taken together. (8) Despite the development of various dressings and methods of treatment using a wide range of drugs, TUs against the background of CVI remain a significant problem. (3,8,9) All this necessitates the search for new methods of treating this pathology.…”