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Relevance of the work is due to the need for new materials that are used in medicine as a substitute for natural bone tissue injuries, fractures, etc. The aim of the work is to obtain composites with improved biocompatible properties based on poly-L-lactide (PLA) and hydroxyapatite (HA) and to perform pilot analysis of interaction PLA, HA, composite PLA-HA with primary human monocytes-derived macrophages in vitro. The pilot experiments using human primary monocytes cultivated on the surface of the samples demonstrated that PLA-HA can stimulate release of anti-inflammatory cytokines that indicates the presence of potential anti-inflammatory properties of the composites

Direct current (DC) reactive magnetron sputtering is as an efficient method for enhancing the biocompatibility of poly (ε-caprolactone) (PCL) scaffolds. However, PCL chemical bonding state, the composition of the deposited coating and their interaction with immune cells remains unknown. Herein, we demonstrated that DC reactive magnetron sputtering of the titanium target in a nitrogen atmosphere leads to the formation of nitrogencontaining moieties and the titanium dioxide coating on the scaffolds surface. We have provided the possible mechanism of PCL fragmentation and coating formation supported by XPS results and DFT calculations. Our preliminary biological studies suggest that DC reactive magnetron sputtering of titanium target could be an effective tool to control macrophage functional responses towards PCL scaffolds as it allows to inhibit respiratory burst while retaining cell viability and scavenging activity.

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