This paper reports a novel design of a quartz crystal microbalance (QCM) for effective preservation of high quality factor and sensitivity in liquid. Many previous attempts have not achieved effective solutions to improve the QCM's performance in liquid. It is challenging to create a device without serious liquid damping effect. Our new design removes this dependence through an acoustic loss isolation layer (vacuum) and a sensing diaphragm, which reduce direct contact area at the interface between the QCM and liquid. The sensing diaphragm plays another important role of keeping the liquid damping effect at a much lower frequency than the operating frequency of the QCM. By successful isolation of the liquid damping effect from the QCM's resonance, we have successfully been able to preserve high Q in liquid. Q of 1603 in air and 1600 in water (less than 1% reduction) have been clearly observed.