We present measurements of superconducting transition temperature, resistivity, magnetoresistivity and temperature dependence of the upper critical field of Ta 4 Pd 3 Te 16 under pressures up to 16.4 kbar. All measured properties have an anomaly at ∼ 2 − 4 kbar pressure range, in particular there is a maximum in T c and upper critical field, H c2 (0), and minimum in low temperature, normal state resistivity. Qualitatively, the data can be explained considering the density of state at the Fermi level as a dominant parameter.