Quaternary ammonium polyethylenimine nanoparticles for treating bacterial contaminated water

Farah, Shady; Aviv, Oren; Laout, Natalia; Ratner, S. B.; Beyth, Nurit; Domb, Abraham J.

doi:10.1016/j.colsurfb.2015.03.006

Cited by 29 publications

(18 citation statements)

References 18 publications

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“…Biomedical materials have evolved with the advent of nanotechnology, making it possible to develop antibacterial dental materials with QAC-functionalized nano-fillers. Quaternary ammonium polyethylenimine (QPEI) nanoparticles are effective against a variety of Gram-positive and Gram-negative bacteria, including clinical isolates of pathogenic bacteria and bacteria in contaminated water [325,326]. The antimicrobial potency of these nanoparticles is attributed to the abundance of QA groups along its backbone.…”

Section: Dental Materialsmentioning

confidence: 99%

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Jiao

Niu

et al. 2017

Progress in Polymer Science

507

317

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a b s t r a c tMicrobial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.Published by Elsevier B.V.

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Section: Dental Materialsmentioning

confidence: 99%

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Jiao

Niu

et al. 2017

Progress in Polymer Science

507

317

View full text Add to dashboard Cite

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“…Quaternization of PEI forms quaternary ammonium groups that are highly effective in antimicrobial action to both Gram‐positive and Gram‐negative due their lytic cationic nature . Quaternary ammonium PEI‐based materials have been used for a variety of applications such as to endow antibacterial activity to restorative composite resins, targeting against clinical isolates of pathogenic bacteria and for eradication of bacteria in water . Other polymers such as poly(2‐dimethylaminoethyl methacrylate) (PDMAEMA), which has been frequently used as a gene transfection agent, have cationic groups which can be used for antibacterial applications .…”

Section: Introductionmentioning

confidence: 99%

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

Yew

Chee

Zhang

et al. 2017

Macro Materials & Eng

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The rise in resistant bacteria strains worldwide is proving to be a challenge to the healthcare industry. These “superbugs” are emerging faster than the rate of new antibiotic discovery. This has a heavy impact on medical devices as they are susceptible to biofilm production. Antimicrobial resistance (AMR) causes infections to be difficult to treat, especially postimplantation of a medical device. To prevent bacterial adhesion on devices, various types are coatings are introduced. By binding antibiotics to polymers, an effective adhesive coating on the surface can be created. However, with AMR on the rise, these polymers are losing their efficacy in the application. Another class of antimicrobial polymers with a different mode of mechanism will be explored in this project. Biocidal polymers are effective antimicrobial agents as they rely on the electrostatic interactions between the polymeric charged groups and the charged microbial membrane. Polyethylenimine (PEI) can be modified to achieve a macromolecule containing various charged cationic groups. Quaternizing low‐molecular‐weight PEI with different alkyl groups of short, long, and aromatic groups will give rise to various structural differences. The structure of the quaternized PEI is characterized, and its antimicrobial activity and compatibility are shown to be remarkably improved.

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“…A ratio to reactive sites of 2.5:1 and 1.5:1 was used, and reagent amounts/volumes were accordingly adjusted. Before and during bromination, beads samples were taken after every 1,8,24, and 72 h. These samples were filtrated and washed with 1 L DDW in 100 mL portion and then dried. Beads were analyzed for Br% by elemental analysis and the iodometric/thiosulfate titration method.…”

Section: Synthesis and Characterizationsmentioning

confidence: 99%

“…4,5 A variety of biocidal polymers, such as phosphonium compounds, 6 quaternary ammonium compounds, 7,8 and N-halamines have been demonstrated to be efficient. They exhibit unique biocidal properties as has been reported.…”

mentioning

confidence: 99%

N‐bromo‐hydantoin grafted polystyrene beads: Synthesis and nano‐micro beads characteristics for achieving controlled release of active oxidative bromine and extended microbial inactivation efficiency

Farah

Aviv

Daif

et al. 2015

J. Polym. Sci. Part A: Polym. Chem.

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N-bromo-hydantoin and N-bromo-5,50 -dimethylhydantoin conjugated polystyrene beads were synthesized from chloromethyl polystyrene beads which differ in their particles size, crosslinking, nano-micro porosity, and tunnels size on the surface, in order to study the effect of these parameters on oxidative halogen release and resultant activity, for water purification applications. The synthesized beads were characterized using elemental analysis, FT-IR, solid state 13 C-NMR, and scanning electron microscope (SEM). The conjugation yield and kinetics in different solvents and bromine loading capacity were studied. The N-bromoamine polystyrene beads were tested for water decontamination according to NSF 231 protocol. The release of active bromine was analyzed by spectrophotometer using a DPD-1 kit and also studied the antimicrobial activity against Escherichia coli and MS2 phages. Bead's nano-micro characteristics were found critical for oxidative halogen release control: rate stabilization and modulation, extension and also influences antimicrobial activity. The synthesized beads exhibited extended and stable release of bromine, 6 and 4 log reduction for E. coli and MS2, respectively for 250 L of passing contaminated water. Thus, N-halamine hydantoins conjugated polystyrenes, chemically or kinetically release modified should have applications as disinfectants in water purification systems as well as medical field.

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Quaternary ammonium polyethylenimine nanoparticles for treating bacterial contaminated water

Cited by 29 publications

References 18 publications

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance

Quarternized Short Polyethylenimine Shows Good Activity against Drug‐Resistant Bacteria

N‐bromo‐hydantoin grafted polystyrene beads: Synthesis and nano‐micro beads characteristics for achieving controlled release of active oxidative bromine and extended microbial inactivation efficiency

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