Quaternized poly (poly(ethylene glycol)methyl ether methacrylate)- b -poly (2-(dimethylamino)ethyl methacrylate) as block copolymers by sequential monomer addition: Dispersion of copper phthalocyanine

Triblock Copolymer Micelles with Tunable Surface Charge as Drug Nanocarriers: Synthesis and Physico-Chemical Characterization

“…The clear solution was concentrated on a rotary evaporator and the product was precipitated in cold hexane. Yield: 0.66 g (80%) 1 The third block was polymerized by modifying a literature procedure [50]. Typically, CuCl (0.017 g, 0.075 mmol) was added to a solution of PLA-b-PDMAEMA (0.3 g, 0.0375 mmol) and OEGMA (0.375 g, 0.75 mmol) in anisole (2.5 mL).…”

“…In the third synthetic stage, the inherent halogen end-functionality of the PLA-b-PDMAEMA diblock copolymer was used to initiate the ATRP of OEGMA-macromonomer (Scheme 1). The polymerization proceeded in anisole for 24 h in the presence of CuCl/PMDETA catalytic complex under modified conditions from the literature [50]. The product was purified via ultrafiltration in water and the degree of OEGMA polymerization was determined from the relative intensities of oxyethylene protons at 3.65 ppm and the methylene protons of DMAEMA repeating units at 4.03 ppm (Figure 1c).…”