Quercetin-3-O-glucuronide promotes the proliferation and migration of neural stem cells

Baral, Samrat; Pariyar, Ramesh; Kim, Jaehyo; Lee, Ho-Sub; Seo, Jooyeok

doi:10.1016/j.neurobiolaging.2016.12.024

Cited by 59 publications

(52 citation statements)

References 64 publications

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“…Baral, Pariyar, Kim, Lee, and Seo () observed opposite effects of quercetin and one of its metabolites, quercetin‐3‐O‐glucuronide (Q3GA) in neural stem cells: while quercetin caused a decrease in Akt phosphorylation and decrease in cell viability, Q3GA promoted Akt phosphorylation and cell proliferation which was shown to be Akt‐dependent. We have also previously demonstrated that a white grape juice extract caused an increase in Akt phosphorylation when incubated with the HK‐2 cells used in the present study (Andreucci et al, ).…”

Section: Discussionmentioning

confidence: 99%

Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells

Andreucci¹,

Faga²,

Pisani³

et al. 2017

Journal Cellular Physiology

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Radiocontrast media (RCM)-induced acute kidney injury (CI-AKI) is a major clinical problem whose pathophysiology is not well understood. Direct toxic effects on renal cells, possibly mediated by reactive oxygen species, have been postulated as contributing to CI-AKI. We investigated the effect of quercetin on human renal proximal tubular (HK-2) cells treated with the radiocontrast medium (RCM) sodium diatrizoate. Quercetin is the most widely studied flavonoid, and the most abundant flavonol present in foods. It has been suggested to have many health benefits, including angioprotective properties and anti-cancer effects. These beneficial effects have been attributed to its antioxidant properties and its ability to modulate cell signaling pathways. Incubation of HK-2 cells with 100 μM quercetin caused a decrease in cell viability and pre-treatment of HK-2 cells with 100 μM quercetin followed by incubation with 75 mgI/ml sodium diatrizoate for 2 hr caused a decrease in cell viability which was worse than in cells treated with diatrizoate alone. However, further incubation of the cells (for 22 hr) after removal of the diatrizoate and quercetin caused a recovery in cell viability in those cells previously treated with quercetin + diatrizoate and quercetin alone. Analysis of signaling molecules by Western blotting showed that in RCM-treated cells receiving initial pre-treatment with quercetin, followed by its removal, an increase in phosphorylation of Akt (Ser473), pSTAT3 (Tyr705), and FoxO3a (Thr32) as well as an induction of Pim-1 and decrease in PARP1 cleavage were observed. Quercetin may alleviate the longer-term toxic effects of RCM toxicity and its possible beneficial effects should be further investigated.

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Section: Discussionmentioning

confidence: 99%

Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells

Andreucci¹,

Faga²,

Pisani³

et al. 2017

Journal Cellular Physiology

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“…Baral's study demonstrated that Q3GA increased NSC proliferation via the Akt/cyclin D1 and BDNF signaling pathway and promoted migration (increased mRNA expression of CXCR4) in vitro and in vivo. In contrast, quercetin induced apoptosis of NSCs, along with Akt dephosphorylation [47]. Preclinical studies suggest that natural compounds modulate neuroplasticity.…”

Section: Research Hao Yangmentioning

confidence: 91%

Modulatory Effects of Natural Products on Neuronal Differentiation

An¹,

Chen²,

Wang³

et al. 2018

Neuropsychiatry

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Neuron loss is the cardinal characteristic of neurodegenerative diseases. Regulation of adult neurogenesis, especially the induction of neuronal differentiation, is important in developing therapies to promote neuronal regeneration from nerve injury or neurological disorders. Neuronal differentiation is extremely complicated because it can occur in different cell types and be caused by a variety of inducers. In recent years, medicinal plant-derived natural compounds have received extensive attention as major sources of new therapeutic agents for treating neurological disorders and they exert their effects by promoting adult neurogenesis. In this study, we summarized the detailed research progress on the active natural compounds with potential neuroprotective effects and their molecular mechanisms on inducing neuronal differentiation and morphogenesis in NS/PCs, MSCs, PC12 cells and neuroblastoma cells. The active ingredients derived from natural plants that efficacious in promoting neuronal differentiation and neurite outgrowth include phenolics, flavonoids, alkaloids, coumarins, terpenes, quinines, glycosides, iridoids, volatile oils and others (xanthone, isothiocyanate). Studies have shown that above natural products exert the promotion effects via regulating many factors involve in the process of neurogenesis, including specific proteins (DCX, β IIItubulin, MAP

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“…Apigenin and luteolin promoted human hematopoietic stem cell differentiation [141] and were confirmed safe for developing vertebrates in terms of neurobehavior [142]. [138] into bone cells Increased Rat BM-MSCs cultures [129], mice BM-MSC cultures [130] Decreased Human BM cell cultures [133] into β-cells Increased Rat BM-MSCs cultures [131] into hepatic cells Increased Human BM cell cultures [134] into fat tissue cells Increased Human BM cell cultures [133] Proinflammatory cytokines Decreased Rat model of spinal cord injury [132] Anti-inflammatory cytokines Increased Rat model of spinal cord injury [132] Angiogenic factor secretion Increased Rat BM-MSC cultures [135] BDNF secretion Increased Human embryonic NSCs culture [138] BDNF: Brain-derived neurotrophic factor, BM: Bone marrow, hHSC: Human hematopoietic stem cells, MSC: Mesenchymal stem cells, NSC: Neural stem cells, hPSCs: Human pluripotent stem cells.…”

Section: Past and Future Perspectivesmentioning

confidence: 94%

“…Baral et al investigated the effects of quercetin on neurodifferentiation and stem cell migration, but their results were inconclusive. Although quercetin increased differentiation and migration, it also decreased cell viability [138]. Apigenin increased the expression of neuronal markers and the number of neural progenitor cells obtained from human embryonic stem cells and human iPSCs [139].…”

Section: Past and Future Perspectivesmentioning

confidence: 99%

Autologous Cord Blood in Children with Cerebral Palsy: A Review

Boruczkowski

Pujal²,

Zdolińska-Malinowska

2019

IJMS

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The aim of this narrative review is to report on the current knowledge regarding the clinical use of umbilical cord blood (CB) based on articles from PubMed and clinical trials registered on ClinicalTrials.gov. An increasing amount of evidence suggests that CB may be used for both early diagnostics and treatment of cerebral palsy. The acidity of CB and its biochemical parameters, including dozens of cytokines, growth factors, and other metabolites (such as amino acids, acylcarnitines, phosphatidylcholines, succinate, glycerol, 3-hydroxybutyrate, and O-phosphocholine) are predictors of future neurodevelopment. In addition, several clinical studies confirmed the safety and efficacy of CB administration in both autologous and allogeneic models, including a meta-analysis of five clinical trials involving a total of 328 participants. Currently, nine clinical trials assessing the use of autologous umbilical CB in children diagnosed with hypoxic-ischemic encephalopathy or cerebral palsy are in progress. The total population assessed in these trials exceeds 2500 patients.

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Quercetin-3-O-glucuronide promotes the proliferation and migration of neural stem cells

Cited by 59 publications

References 64 publications

Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells

Quercetin protects against radiocontrast medium toxicity in human renal proximal tubular cells

Modulatory Effects of Natural Products on Neuronal Differentiation

Autologous Cord Blood in Children with Cerebral Palsy: A Review

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