Quercetin alleviates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats

Ramachandra, Rashmi; Shetty, Ajaya Kumar; Salimath, Paramahans V.

doi:10.1002/mnfr.200400084

Cited by 31 publications

(22 citation statements)

References 41 publications

(39 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protective effects of quercetin in diabetes mellitus and DN have also been reported in rat models (12)(13)(14). Our data showed that quercetin treatment at 40 µM led to smaller cells with irregular shapes, larger gaps between adjacent cells, and weakened cell adhesion (Fig.…”

Section: Effects Of Quercetin On Morphology and Proliferation In Highsupporting

confidence: 77%

“…Protective effects of quercetin in diabetes mellitus and DN have also been reported in rat models (10)(11)(12). In addition, the protective effects of quercetin have been observed in a streptozotocin (STZ)-induced model of diabetes mellitus (11)(12)(13)(14). Furthermore, Kim et al (15) reported that dietary quercetin attenuated fasting and postprandial hyperglycemia.…”

Section: Introductionmentioning

confidence: 92%

See 1 more Smart Citation

Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model

Chen

Shi

et al. 2012

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Diabetic nephropathy (DN), which is characterized by mesangial cell proliferation, is a common complication observed in diabetic patients. The protective effects of quercetin for DN have been reported; however, the mechanism has yet to be determined. We aimed to identify the underlying mechanism for quercetin protection against DN. High glucose (HG)-induced human mesangial cell (HMC) proliferation, a feature of the early stages of diabetic nephropathy, was employed as an in vitro model. Cells were grown in normal glucose (5.6 mM), high glucose (30 mM) or high glucose with various concentrations of quercetin. Cell proliferation, cell cycle progression, and expression of NF-κB and MCP-1 were examined by MTT assay, DNA staining, immunocytochemistry and western blot analysis, respectively. HMCs cultured in high glucose had signficantly greater proliferation, accumulation in the G1 phase, upregulated NF-κB and MCP-1 expression. Quercetin treatment reversed the effects of high glucose in a dose-dependent manner. Cotreatment of quercetin with pyrrolidine dithiocarbamate (PDTC), an inhibitor of NF-κB activation, suggest that the effects of quercetin are partially mediated by NF-κB signaling. Quercetin partially suppresses the effects of high glucose in HMC cultures, which are mediated at least in part through the suppression of NF-κB.

show abstract

Section: Effects Of Quercetin On Morphology and Proliferation In Highsupporting

confidence: 77%

Section: Introductionmentioning

confidence: 92%

Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model

Chen

Shi

et al. 2012

Int J Mol Med

View full text Add to dashboard Cite

show abstract

“…43,16 Moreover, some studies have shown that polyphenolic compounds may reduce the activity of endogenous enzymes in the small intestine and thereby may influence the regulation of blood glucose levels. 22,46 In summary, the present experiment demonstrated that some of the positive changes in the cecal metabolism of rats that resulted from the ingestion of a diet enriched only with FOS were suppressed or slightly suppressed by the addition of an ET strawberry extract. The pH value, SCFA production, and β-glucuronidase activity in the cecum of rats fed with FOS were affected upon the addition of the ET strawberry extract.…”

Section: ■ Discussionmentioning

confidence: 81%

Strawberry Ellagitannins Thwarted the Positive Effects of Dietary Fructooligosaccharides in Rat Cecum

Fotschki

Milala

Jurgoński

et al. 2014

J. Agric. Food Chem.

View full text Add to dashboard Cite

Forty-eight male Wistar rats were fed diets containing low (0.051% of diet) or high (0.153% of diet) levels of an ellagitannin-rich (ET) strawberry extract with dietary fructooligosaccharides (FOS) or cellulose (CEL) for 4 weeks. The in vivo study demonstrated that some positive changes in the cecal metabolism resulting from the ingestion of a diet enriched only with FOS were completely or slightly suppressed by the dietary ET. In particular, the pH value (7.21 vs 7.36), short-chain fatty acid production (41.2 vs 30.0 μmol/100g BW), and β-glucuronidase activity (20.2 vs 15.7 μmol/h/g) in the cecum of rats fed with FOS were affected upon the addition of the ET extract. Dietary FOS caused higher metabolism of the tested ET strawberry extract in the gastrointestinal tract of rats. Moreover, the systemic effect of the supplements when consumed together showed undesired serum HDL-cholesterol decrease (0.78 vs 1.02 mmol/L in the treatment with FOS only).

show abstract

“…Chronic consumption of QE (0.1% of diet) decreased blood glucose in STZ-treated rats [6,7]. QE protected pancreatic β cells from oxidative stress and damage, resulting in increased insulin secretion in STZ-treated rats [5].…”

Section: Discussionmentioning

confidence: 99%

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus

et al. 2011

View full text Add to dashboard Cite

The objective of this study was to investigate the hypoglycemic effects of quercetin (QE) in animal models of diabetes mellitus (DM). A starch solution (1 g/kg) with and without QE (100 mg/kg) or acarbose (40 mg/kg) was orally administered to streptozotocin (STZ)-induced diabetic rats after an overnight fast. Postprandial plasma glucose levels were measured and incremental areas under the response curve were calculated. To study the effects of chronic feeding of QE, five-week-old db/db mice were fed an AIN-93G diet, a diet containing QE at 0.08%, or a diet containing acarbose at 0.03% for 7 weeks after 1 week of adaptation. Plasma glucose and insulin, blood glycated hemoglobin, and maltase activity of the small intestine were measured. Oral administration of QE (100 mg/kg) or acarbose (40 mg/kg) to STZ-treated rats significantly decreased incremental plasma glucose levels 30-180 min after a single oral dose of starch and the area under the postprandial glucose response, compared with the control group. QE (0.08% of diet) or acarbose (0.03% of diet) offered to db/db mice significantly reduced both plasma glucose and blood glycated hemoglobin compared to controls without significant influence on plasma insulin. Small intestine maltase activities were significantly reduced by consumption of QE or acarbose. Thus, QE could be effective in controlling fasting and postprandial blood glucose levels in animal models of DM.

show abstract

Quercetin alleviates activities of intestinal and renal disaccharidases in streptozotocin-induced diabetic rats

Cited by 31 publications

References 41 publications

Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model

Quercetin suppresses NF-κB and MCP-1 expression in a high glucose-induced human mesangial cell proliferation model

Strawberry Ellagitannins Thwarted the Positive Effects of Dietary Fructooligosaccharides in Rat Cecum

Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus

Contact Info

Product

Resources

About