Quercetin alleviates acute kidney injury by inhibiting ferroptosis

Wang, Yue; Quan, Fei; Cao, Qiu-Hua; Lin, Yining; Yue, Chongxiu; Bi, Ran; Cui, Xinmeng; Yang, Hongbao; Yang, Yong; Birnbaumer, Lutz; Li, Xianjing; Gao, Xinghua

doi:10.1016/j.jare.2020.07.007

Cited by 385 publications

(249 citation statements)

References 52 publications

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“… 17 The levels of lipid ROS can be determined using BODIPY-C11 dye. 18 , 19 Lipoxygenases (LOXs) may be involved in the formation of iron-dependent lipid ROS by catalysing the oxidation of PUFAs into lipid hydroperoxides and forming toxic lipid-free radicals in the presence of a large number of iron ions in the cytoplasm, which may eventually lead to cell damage. 20 Meanwhile, protons beside PUFAs can be transferred by these toxic lipid-free radicals and then start a new round of lipid oxidation reactions, which eventually lead to more severe oxidative damage.…”

Section: Mechanisms Of Ferroptosismentioning

confidence: 99%

Role of Ferroptosis in Lung Diseases

Xu¹,

Deng²,

Hu³

et al. 2021

JIR

101

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Ferroptosis is a new type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress and cell death. The metabolism of iron, lipids, and amino acids and multiple signalling pathways precisely regulate the process of ferroptosis. Emerging evidence has demonstrated that ferroptosis participates in the occurrence and progression of various pathological conditions and diseases, such as infections, neurodegeneration, tissue ischaemia-reperfusion injury and immune diseases. Recent studies have also indicated that ferroptosis plays a critical role in the pathogenesis of acute lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infection and asthma. Herein, we summarize the latest knowledge on the regulatory mechanism of ferroptosis and its association with iron, lipid and amino acid metabolism as well as several signalling pathways. Furthermore, we review the contribution of ferroptosis to the pathogenesis of lung diseases and discuss ferroptosis as a novel therapeutic target for various lung diseases.

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Section: Mechanisms Of Ferroptosismentioning

confidence: 99%

Role of Ferroptosis in Lung Diseases

Xu¹,

Deng²,

Hu³

et al. 2021

JIR

101

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“…Moreover, acute treatment with quercetin before I/R prevented mouse kidney function and limited morphological alterations. In this model, quercetin reduced tubular necrosis, renal inflammation and increased the levels of antioxidant pathways and GSH (190). In addition to its effect on ferroptosis, a plausible explanation for the effects of quercetin is the induction of the antioxidant enzyme HO-1 (191).…”

Section: F) Inhibitors Of Ferroptosismentioning

confidence: 82%

“…Flavonoids form a class of polyphenolic compounds (tannins in the broad sense) ubiquitous in vascular plants (including vegetables and cereals). An in vitro study has shown that quercetin inhibits ferroptosis in renal proximal tubular epithelial cells (190). Moreover, acute treatment with quercetin before I/R prevented mouse kidney function and limited morphological alterations.…”

Section: F) Inhibitors Of Ferroptosismentioning

confidence: 99%

Targeting oxidative stress, a crucial challenge in renal transplantation outcome

Carcy

Cougnon

Poët

et al. 2021

Free Radical Biology and Medicine

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“…In this study, quercetin was the most significant compound, which is closely related to semen quality. Quercetin, a compound belonging to the flavonol class, has extensive pharmacological actions, such as antioxidant and anti-inflammatory effects [ 32 ]. In vitro experiments have shown that adding quercetin to semen can elevate the total antioxidant potential and ameliorate lipid peroxidation during cryopreservation to improve sperm motility, acrosome integrity, plasma membrane integrity, mitochondrial activity and chromatin condensation [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

A network pharmacology approach to determine the underlying mechanisms of action of Yishen Tongluo formula for the treatment of oligoasthenozoospermia

Chen

Sun

2021

PLoS ONE

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Oligoasthenozoospermia is a complex disease caused by a variety of factors, and its incidence is increasing yearly worldwide. Yishen Tongluo formula (YSTLF), created by Professor Sun Zixue, has been used to treat oligoasthenozoospermia in clinical practice for several decades with a good therapeutic effect. However, the chemical and pharmacological profiles of YSTLF remain unclear and need to be elucidated. In this study, a network pharmacology approach was applied to explore the potential mechanisms of YSTLF in oligoasthenozoospermia treatment. All of the compounds in YSTLF were retrieved from the corresponding databases, and the bioactive ingredients were screened according to their oral bioavailability (OB) and drug-likeness (DL). The potential proteins of YSTLF were obtained from the traditional Chinese medicine systems pharmacology (TCMSP) database and the Bioinformatics Analysis Tool for Molecular Mechanism of Traditional Chinese Medicine (BATMAN-TCM) database, while the potential genes of oligoasthenozoospermia were obtained from the GeneCards database and the DisGeNET database. The STRING database was used to construct an interaction network according to the common targets identified by the online tool Venny for YSTLF and oligoasthenozoospermia. The topological characteristics of nodes were visualized and analyzed through Cytoscape. Biological functions and significant pathways were determined and analyzed using the Gene Ontology (GO) knowledgebase, the Kyoto Encyclopedia of Genes and Genomes (KEGG) and Metascape. Finally, the disease-formula-compound-target-pathway network was constructed by Cytoscape. A total of 106 bioactive ingredients and 134 potential targets from YSTLF were associated with oligoasthenozoospermia or considered to be therapeutically relevant. Pathway analysis indicated that the PI3K/Akt, MAPK and apoptosis signaling pathways were significant pathways involved in oligoasthenozoospermia. In conclusion, the current study expounded the pharmacological actions and molecular mechanisms of YSTLF in treating oligoasthenozoospermia from a holistic viewpoint. The potential molecular mechanisms were closely related to antioxidative stress, antiapoptosis and anti-inflammation, with TNF, CCND1, ESR1, NFKBIA, NR3C1, MAPK8, and IL6 being possible targets. This network pharmacology prediction may offer a helpful tool to illustrate the molecular mechanisms of the Chinese herbal compound YSTLF in oligoasthenozoospermia treatment.

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Quercetin alleviates acute kidney injury by inhibiting ferroptosis

Cited by 385 publications

References 52 publications

Role of Ferroptosis in Lung Diseases

Role of Ferroptosis in Lung Diseases

Targeting oxidative stress, a crucial challenge in renal transplantation outcome

A network pharmacology approach to determine the underlying mechanisms of action of Yishen Tongluo formula for the treatment of oligoasthenozoospermia

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