2019
DOI: 10.1016/j.freeradbiomed.2019.09.024
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Quercetin alleviates rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages

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Cited by 223 publications
(165 citation statements)
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References 62 publications
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“…Through the screening of active ingredients and analysis of compound-target network, quercetin, kaempferol, wogonin, and baicalein were identified to be the most important active ingredients of EU-RAB in the treatment of OA. Previous studies have shown that quercetin promotes chondrocytes proliferation and acts on inflammatory injury to accelerate cartilage repair [32]. Increasingly evidence has associated kaempferol with the inflammation process.…”
Section: Discussionmentioning
confidence: 99%
“…Through the screening of active ingredients and analysis of compound-target network, quercetin, kaempferol, wogonin, and baicalein were identified to be the most important active ingredients of EU-RAB in the treatment of OA. Previous studies have shown that quercetin promotes chondrocytes proliferation and acts on inflammatory injury to accelerate cartilage repair [32]. Increasingly evidence has associated kaempferol with the inflammation process.…”
Section: Discussionmentioning
confidence: 99%
“…To alleviate dextran sodium sulphate-induced experimental colitis, the soya genistein induces macrophage polarization of M1 towards M2 macrophages and reduces systemic cytokines [24]. In addition, quercetin modulates synovial macrophages polarization to M2 macrophages, hence creating a pro-chondrogenic microenvironment for chondrocytes to enhance cartilage repair under osteoarthritis condition [44]. Accordingly, these natural compounds may boost the induction of macrophage polarization with M2 phenotype in the pathogenesis of infectious and autoimmune diseases.…”
Section: Discussionmentioning
confidence: 99%
“…Imperatorin (IMT) reduced the release of TNF-α, IL-6 and IL-1β, inhibited the expression of iNOS and COX-2, and suppressed the activity of NF-κB via upregulation of the expression of p65 (C) and IκB (C), and downregulation of the expression of p65 (N) [16]. Quercetin alleviated rat osteoarthritis by inhibiting inflammation and apoptosis of chondrocytes, modulating synovial macrophages polarization to M2 macrophages [17]. The pharmacological effects of Sanse powder may be a synergy of actions of multicomponents.…”
Section: Chemical Constituents Of "Sanse Powder" Prescriptionmentioning
confidence: 99%