Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect

Yang, Yan; Zhang, Xu; Xu, Min; Wu, Xin; Zhao, Fei; Zhao, Chengzhi

doi:10.1016/j.intimp.2017.11.013

Cited by 111 publications

(80 citation statements)

References 41 publications

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“…Moreover, this drug reduced swelling of the paw in model rats with arthritis; inhibited the proliferation and transfer of synovial cells and release of in ammatory cytokines; decreased the protein expression of in ammasome NLRP3, caspase-1, and IL-1β; inhibited in ammatory cell in ltration and angiogenesis; promoted apoptosis; reduced serum in ammatory factors IL-1β and TNF-α levels; and signi cantly inhibited the in ammatory reaction. Clinically, Herba tuberculate speranskia is used mostly for external application in rheumatic arthralgia, bone and muscle contracture, and pyogenic infections [13,[21][22][23][24][25]. In summary, the external application of this compound had antibacterial, anti-in ammatory, analgesic, and anticoagulatory effects against AGA.…”

Section: Discussionmentioning

confidence: 99%

Effects of external application of compound Qingbi granules on acute gouty arthritis with dampness-heat syndrome: A randomized control trial

Ren¹,

Meng²,

Liu

et al. 2020

Preprint

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Abstract Background The use of anti-inflammatory and analgesic drugs such as nonsteroidal anti-inflammatory drugs(NSAIDs) for treating acute gout has limitations, such as a high incidence of adverse reactions in the gastrointestinal tract and toxicity in the liver, kidney, and heart. Hence, a new safe and effective treatment approach to reduce the use of anti-inflammatory and analgesic drugs, incidence of adverse reaction, and patients’ burden needs to be explored. This randomized controlled clinical trials investigated the clinical efficacy and safety of external application of compound Qingbi granules (CQBG) in treating acute gouty arthritis, providing evidence for designing a safe and effective optimization protocol of acute gouty arthritis (AGA) comprehensive treatment. Methods A total of 90 patients in line with the diagnostic standard of AGA were recruited and divided randomly into control, T1, and T2 groups (30 in each group). Participators in three groups all received Western–medicine–bastic treatment (low-purine diet, drinking water more than 2000 mL/d, oral loxoprofen, and NAHCO3). Besides, the T1 group received an external application of diclofenac diethylamine emulgel, while the T2 group received an external application of CQBG. Participators in control group were treated by single-use Western–medicine–bastic treatment. With a treatment course of 7 days and a follow-up for subsequent 7 days, the three groups were compared in terms of primary outcome indicators including swelling, pain improvement, and change in pain duration and secondary outcome indicators including serum C-reactive protein (CRP), uric acid (UA), and change in thickness of the inflammatory synovium of joints under ultrasound. Meanwhile, the safety of the protocol was evaluated. Results The three groups of patients had no obvious differences in age, body mass index, history of gout, complication, and so on before recruitment. A comparison between pretreatment and post-treatment revealed remarkable reductions in the arthralgia VAS score and the swelling score in the three groups after the treatment and the improvements in the T2 group were more obvious than those in the T1 and control groups (P < 0.05). Regarding onset-time of pain improvement and pain duration, the T2 group had more significant efficacy compared with the other two groups (P < 0.05). The serum CRP and blood UA levels in the three groups significantly decreased after the treatment, but with no significant inter-group difference. The improvement in thickness of the inflammatory synovium in joints tested by ultrasound was more significant in the T2 group than in the control group (P < 0.05). For safety evaluations, no significant difference in the incidence of adverse events was found. Conclusions The external application of CQBG combined with Western–medicine–bastic treatment in patients with AGA improved arthralgia and swelling, shortened the period of taking NSAIDs, and reduced the levels of CRP and serum UA. Its therapeutic effect was significantly better than the effect of single-use Western medicine bastic treatment and additive diclofenac diethylamine emulgel. The study provided evidence for the clinical application of CQBG combined with Western medicine in treating AGA. Trial registration: ChiCTR, ChiCTR1800018020. Registered 27 August 2018, http://www.chictr.org.cn/showproj.aspx?proj=27138

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Section: Discussionmentioning

confidence: 99%

Effects of external application of compound Qingbi granules on acute gouty arthritis with dampness-heat syndrome: A randomized control trial

Ren¹,

Meng²,

Liu

et al. 2020

Preprint

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“…Some previous researches have shown that betulinic acid, kaempferol, leonurine, oxymatrine, and piperlongumine can inhibit the migration and invasion of FLS in RA models (Li et al, ; Liang et al, ; Liu, Feng, et al, ; Pan et al, ; Sun, Xu, Du, Zhang, & Zhu, ). Triptolide, celastrol, geniposide, paeoniflorin, clematichinenoside AR, glycyrrhetinic acid, kirenol, cucurbitacin E, 1,7‐dihydroxyl‐3,4‐dimethoxylxanthone, calycosin, catechin, cyanidin‐3‐glucoside, quercetin, α‐mangostin, leonurine, norisoboldine, oxymatrine, caffeic acid, paeonol, resveratrol, shikonin, and 3 R ‐(4′‐hydroxyl‐3′‐ O ‐β‐ d ‐glucopyranosyl phenyl)‐dihydro isocoumarin alleviate inflammatory response by inhibiting the release of a variety of proinflammatory factors (e.g., activin A, ciliary neurotrophic factor, and fractalkine) in FLS of RA models (Bi et al, ; Chen et al, ; Deng et al, ; Huang et al, ; Jia et al, ; Li et al, ; Liang et al, ; Lin, Sato, & Ito, ; Liu, Feng, et al, ; Mao, Sun, Pei, & Zhang, ; Su et al, ; Su et al, ; Sun et al, ; Sun et al, ; Sun & Li, ; Sung et al, ; Tang et al, ; Tian, Chen, Gao, Li, & Xie, ; Venkatesha, Astry, Nanjundaiah, Yu, & Moudgil, ; Wang, Sun, & Jin, ; Wei et al, ; Yang et al, ; Yang et al, ; Zhang et al, ; Zheng et al, ; Zuo et al, ).…”

Section: The Anti‐ra Activities Of Chemical Constituents From Herbal mentioning

confidence: 99%

“…Multiple inflammatory indices (e.g., TNF‐α, IL‐1, and IL‐6) are dysregulated in the peripheral blood of RA patients, which may also participate in the mechanisms of some constituents against RA, including triptolide; paeoniflorin; artesunate; artemether; glycyrrhizin; madecassoside; taraxasterol; apigenin; luteolin; quercetin; 1,7‐dihydroxyl‐xanthone; 2‐hydroxyl‐1,7‐dimethoxylxanthone; 1,7‐dihydroxyl‐3,4‐dimethoxylxanthone; berberine; norisoboldine; oxymatrine; sinomenine; curculigoside A; curcumin; ferulic acid; p‐coumaric acid; daphnetin; and matrine (Cai, Zheng, Shang, Zhao, & R., Y., ; Cuzzocrea, Saadat, Di Paola, & Mirshafiey, ; Ding et al, ; Gao, Shan, Di, Jiang, & Xu, ; Huang et al, ; Impellizzeri et al, ; Jia & He, ; Jiang, Ping, Sun, Wang, & Sun, ; Li et al, ; Lin et al, ; Luo et al, ; Ma et al, ; Pu et al, ; Shi, Zhou, Ji, Xu, & Yang, ; Tu, Hu, & Lu, ; Wang et al, ; Wang, Mo, & Zhang, ; Yang, Zhang, et al, ; Zhai et al, ; Zheng et al, ; Zhou, Wong, Wang, Cai, & Liu, ; Zhu et al, ; Zhu et al, ; Zuo, Xia, Li, & Chen, ). In addition, some kinds of cells in peripheral blood are also involved in the inflammatory processes of RA.…”

Section: The Anti‐ra Activities Of Chemical Constituents From Herbal mentioning

confidence: 99%

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Zhang

2019

Phytotherapy Research

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Rheumatoid arthritis (RA) is a systemic disease characterized by autoimmunity, joint inflammation, and cartilage destruction, which affects 0.5–1% of the population. Many compounds from herbal medicines show the potentials to treat RA. On this basis, the compounds with good pharmacokinetic behaviors and drug‐likeness properties will be further studied and developed. Therefore, the herbal compounds with anti‐RA activities were reviewed in this paper, and the cheminformatics tools were used to predict their drug‐likeness properties and pharmacokinetic parameters. A total of 90 herbal compounds were analyzed, which were reported to be effective on RA models through anti‐inflammation, chondroprotection, immunoregulation, antiangiogenesis, and antioxidation. Most of the herbal compounds have good drug‐likeness properties. Most of the compounds can be an alternative and valuable source for anti‐RA drug discovery.

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“…Catechin also inhibited MSU-induced IL-1β secretion and NLRP3 inflammasome activation in MSU-challenged THP-1 cells in a ROS-dependent manner (Jhang et al, 2015). Similarly, in a collagen-induced model of arthritis, quercetin inhibited inflammasome activation and associated inflammatory induction (Yang et al, 2018). The administration of the polyphenol quercetin prior to spinal cord injury in mice, which similarly decreased NLRP3 mediated cytokine production through the downregulation of ROS (Jiang et al, 2016).…”

Section: Grape-derived Polyphenolic Compounds Attenuate Risk Factors mentioning

confidence: 99%

Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

et al. 2018

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Neurodegenerative disorders constitute a group of multifaceted conditions characterized by the progressive loss of neurons and synaptic connections consequent to a combination of specific genetic predispositions and stochastic stressors. The neuropathologies observed in both Alzheimer’s and Parkinson’s disease are in part attributed to compounding intrinsic and extrinsic environmental stressors, which we propose may be limited by the administration of specific grape derived phytochemicals and their metabolized derivatives, specifically polyphenols isolated from grape botanicals. Current therapies for neurodegenerative disorders are limited as they solely target the final disease pathologies including behavioral changes, cognitive deficits, proteinopathies and neuronal loss; however, this strategy is not a sustainable approach toward managing disease onset or progression. This review discusses the application of grape derived polyphenols as an adjunctive treatment paradigm for the prevention of neuropathologies associated with Alzheimer’s disease, Parkinson’s disease and Chronic Traumatic Encephalopathy by simultaneously ameliorating two stochastic stressors that facilitate their disease pathologies: inflammation and oxidative stress. The biophysical attributes of grape-derived polyphenols buffer against redox potential dependent peripheral and neuroinflammation and down regulate the activation of inflammasomes in microglia and astrocytes, which could provide a novel mechanism through which grape-derived polyphenols simultaneously suppress risk factors across pathologically distinct neurodegenerative conditions. This approach therefore offers a prophylactic mode, not feasible through current pharmacological agents, to target activity dependent risk factors for neurodegenerative disorders that manifest over an individual’s lifetime.

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Quercetin attenuates collagen-induced arthritis by restoration of Th17/Treg balance and activation of Heme Oxygenase 1-mediated anti-inflammatory effect

Cited by 111 publications

References 41 publications

Effects of external application of compound Qingbi granules on acute gouty arthritis with dampness-heat syndrome: A randomized control trial

Effects of external application of compound Qingbi granules on acute gouty arthritis with dampness-heat syndrome: A randomized control trial

Herbal compounds for rheumatoid arthritis: Literatures review and cheminformatics prediction

Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols

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