Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines

Aghapour, Fahimeh; Moghadamnia, Ali Akbar; Nicolini, Andrea; Kani, Seydeh Narges Mousavi; Barari, Ladan; Morakabati, Payam; Rezazadeh, Leyla; Kazemi, Sohrab

doi:10.1016/j.bbrc.2018.04.174

Cited by 70 publications

(34 citation statements)

References 20 publications

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“…However, the bioavailability of quercetin is limited and affected by several factors including gender, source, and form of quercetin (reviewed in) . Methods to improve bioavailability are actively being sought and techniques such as liposomal and nanoparticle‐based delivery and targeted delivery to tumors are finding success …”

Section: Discussionmentioning

confidence: 99%

Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells

Sundaram¹,

Hussain²,

Haque

et al. 2019

J of Cellular Biochemistry

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The central role of epigenomic alterations in carcinogenesis has been widely acknowledged, particularly the impact of DNA methylation on gene expression across all stages of carcinogenesis is considered vital for both diagnostic and therapeutic strategies. Dietary phytochemicals hold great promise as safe anticancer agents and effective epigenetic modulators. This study was designed to investigate the potential of a phytochemical, quercetin as a modulator of the epigenetic pathways for anticancer strategies. Biochemical activity of DNA methyltransferases (DNMTs), histone deacetylases (HDACs), histone methyltransferases (HMTs), and global genomic DNA methylation was quantitated by an enzyme‐linked immunosorbent assay based assay in quercetin‐treated HeLa cells. Molecular docking studies were performed to predict the interaction of quercetin with DNMTs and HDACs. Quantitative methylation array was used to assess quercetin‐mediated alterations in the promoter methylation of selected tumor suppressor genes (TSGs). Quercetin induced modulation of chromatin modifiers including DNMTs, HDACs, histone acetyltransferases (HAT) and HMTs, and TSGs were assessed by quantitative reverse transcription PCR (qRT‐PCR). It was found that quercetin modulates the expression of various chromatin modifiers and decreases the activity of DNMTs, HDACs, and HMTs in a dose‐dependent manner. Molecular docking results suggest that quercetin could function as a competitive inhibitor by interacting with residues in the catalytic cavity of several DNMTs and HDACs. Quercetin downregulated global DNA methylation levels in a dose‐ and time‐dependent manner. The tested TSGs showed steep dose‐dependent decline in promoter methylation with the restoration of their expression. Our study provides an understanding of the quercetin's mechanism of action and will aid in its development as a candidate for epigenetic‐based anticancer therapy.

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Section: Discussionmentioning

confidence: 99%

Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells

Sundaram¹,

Hussain²,

Haque

et al. 2019

J of Cellular Biochemistry

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“…9 Even if wellknown and characterized, thanks to its strong biological activity, quercetin is of continuously rising scientific interest. [10][11][12] For introducing a carboxylic acid linker into quercetin without affecting its function we chose to address the 7-hydroxy group. This was achieved by first completely acetylating quercetin with an excess of acetic anhydride in pyridine at 70 1C.…”

mentioning

confidence: 99%

Silica particles with a quercetin–R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus

et al. 2019

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“…Quercetin (QC), a flavonol from the flavonoid group of polyphenols, is produced by plants, including Allagopappus viscosissimus, Opuntia ficus-indica var. saboten, Lychnophora staavioides, and Rhamnus species (12,13). The geographical distribution determines, it is found in more than twenty pants material (14).…”

Section: Quercetinmentioning

confidence: 99%

“…QC promotes apoptosis in a wide variety of cells, including those of prostate, lung, breast, colon, and cervical cancers (15). In addition, nanoparticles containing QC reduce the growth of cancer cells and cause them to undergo apoptosis, (12). To promote apoptosis of cancer cells, QC decreases the expression of anti-apoptotic proteins, such as survivin, Bcl-xL, and Bcl-2, and increases the expression of the proapoptotic proteins, such as Bad and Bax, (15).…”

Section: Quercetinmentioning

confidence: 99%

shy Role of natural compounds in preventing and treating breast cancer

et al. 2020

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Breast cancer (BrCa) is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women. Alarming increases in the cases quests for more effective treatment of BrCa. As most chemotherapeutic drugs are associated with drug resistance, cancer relapse, and side effects, scientists are turning to agents with more efficacy, such as natural compounds for treatment and prevention of BrCa. Selected natural compounds, substances derived from living organisms, promote apoptosis and inhibit metastasis, preventing cancer growth. As a result, these compounds have the potential to suppress BrCa progression, thus increasing patient survival rates and decreasing the number of BrCa-related deaths. In this review, we summarize natural compounds that have displayed, anti-cancer effects on BrCa cells in various studies. These natural compounds inhibit the development of BrCa, suppress the growth of cancer cells, and promote cell death. We conclude that natural compounds are efficient, effective and promising agents for treating BrCa other than therapeutic methods.

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Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines

Cited by 70 publications

References 20 publications

Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells

Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells

Silica particles with a quercetin–R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus

shy Role of natural compounds in preventing and treating breast cancer

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