Quercetin flavonoid and vitamin C recuperate kidney functions in potassium bromate-induced renal dysfunction in Wistar rats

Ogagayere, Lucky Omamuzo; Naiho, A. O.; Emojevwe, Victor; Igweh, J. C.

doi:10.1007/s00210-023-02571-w

Cited by 2 publications

(4 citation statements)

References 28 publications

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“…Increased HIF signalling may also explain the atypical precapillary spiralling ob-served in our study, as the HIF pathway also increases the production of vascular endothelial growth factor (VEGF) [9]. Finally, testicular hypoxia leads to fibrosis through the activation of transforming growth factor-β (TGF-β) transcription [8]. Hypoxia-induced testicular fibrosis has also been demonstrated in studies by Abdelhameed RFA et al [10].…”

Section: морфологія / Morphologysupporting

confidence: 72%

“…Long-term central deprivation of luteinising hormone synthesis leads to the development of oxidative stress in the testes [7]. Nitric oxide production during central deprivation of LH synthesis undergoes complex changes: from an initial decrease in NO synthase-dependent nitric oxide production to hyperproduction of nitric oxide from NO synthases [8]. Reduced cNOS activity may contribute to the endothelial dysfunction observed in the microvasculature on day 270 of the experimental model with tryptorelin and quercetin supplementation.…”

Section: морфологія / Morphologymentioning

confidence: 99%

“…Since spermatogenesis requires multiple cell divisions, this process is highly energy dependent. At this stage of the experiment, the absence of nitric oxide derived from cNOS leads to hypoxia, which in turn increases the signalling of the hypoxia-inducible factor [8]. In 2002, at the second international conference of the Society for the Study of Nitric Oxide, it was reported that quercetin restored the activity of flavin-containing monooxygenase, which is normally inhibited by nitric oxide in rats.…”

Section: морфологія / Morphologymentioning

confidence: 99%

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The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

Stetsuk,

Shepitko,

Zaporozhets

et al. 2024

VPBM

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Connection of the publication with planned research works.The study is a fragment of the research project "Experimental and morphological study of the effect of dipherelin, ethanol and 1% methacrylic acid, cryopreserved placental transplants on the morphological and functional state of a number of internal organs", state registration number 0119U102925.Introduction.In 1976, Stanlid reported that some phenolic compounds, including quercetin-3-O-rhamnoside (Q3R, also known as quercetin) and dihydroquercetin, may be involved in polar auxin transport in plants. Quercetin is thought to act as a natural phytotrophin involved in the transport of polar auxin, according to Bruun et al. (1992). On the other hand, wounding during rupture can trigger the production of quercetin-3-D-galactoside (known as hyperoside, Q3DG), which indirectly induces a rooting response (Osterc et al., 2007a). Zohra et al. (2011), [1]. working with grape cuttings, observed that quercetin synthesis coincided with rhizogenesis and suggested a direct role of this compound in grapes. Quercetin (rutin aglycone) and rutin are two flavonols that have been extensively studied in several models of intestinal inflammation. There are a large number of clinical trials evaluating the effects of quercetin on diseases, mainly as a product to reduce uric acid levels, improve neuromuscular function and neuroprotection, reduce the effects of inflammatory factors in myocardial infarction, chronic obstructive pulmonary disease, and Covid-19. On the other hand, quercetin has several effects in experimental models of intestinal inflammation and in vitro studies. Quercetin acts as an important antioxidant compound that reduces MPO activity, reduces colonic oxidative stress in acetic acid, trinitrobenzene sulfonic acid models, and counteracts inflammationinduced glutathione depletion. In addition, quercetin acted by modulating the intestinal microbiota, restoring the integrity of the colon epithelium and creating other protective effects [2]. Similar effects have also been observed with rutin in several preclinical studies.

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Section: морфологія / Morphologysupporting

confidence: 72%

Section: морфологія / Morphologymentioning

confidence: 99%

Section: морфологія / Morphologymentioning

confidence: 99%

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The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

Stetsuk,

Shepitko,

Zaporozhets

et al. 2024

VPBM

View full text Add to dashboard Cite

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“…It is a natural polyphenol which is commonly found in various fruits and vegetables, such as citrus, potatoes, cabbage, peas, beans, apples, and ginkgo. QU has the effects of treating cardiovascular disease [ 10 , 11 ], anti-inflammatory [ 12 , 13 ], asthma [ 14 ], anti-nephrotoxicity [ 15 ], antioxidant [ 16 ], anti-cancer [ 17 ], and so on. Historical and epidemiological evidence shows that diet plans, including flavonoid such as quercetin, have positive health benefits, especially for the heart.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity of Quercetin-Containing Liposomes-in-Gel and Its Effect on Prevention and Treatment of Cutaneous Eczema

Liu,

Cheng,

et al. 2023

Pharmaceuticals

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Cutaneous eczema is a kind of skin disease is characterized by inflammation. The main manifestations are various types of dermatitis, eczema, and urticaria. There are usually complications such as erythema, blisters, and epidermal peeling. The quercetin might have a therapeutic effect on cutaneous eczema due to its favorable antioxidant activity and anti-inflammatory effects. Currently, there are few studies on transdermal administration of antioxidant drugs for the treatment of cutaneous eczema. The aim of this study was to prepare quercetin-containing liposomes-in-gel (QU-LG), its antioxidant properties were evaluated, and it was used in the skin of mice suffering from dermal eczema to see if it had preventive and therapeutic effects in an attempt to make it a new option for the treatment of cutaneous eczema. QU-LG was prepared by the injection method to form the quercetin-containing liposomes (QU-L) and evenly dispersed in the natural dissolution of carboxymethylcellulose sodium (1%, CMC-Na). The release of QU-LG across the dialysis membranes was up to 30% and clearance of 1,1-diphenyl-2-picrylhydrazyl (DPPH) was 65.16 ± 3.513%. In anti-oxidation assay QU-LG inhibited malondialdehyde (MDA) production in liver better than the commercially available drug dexamethasone acetate cream. Compared with untreated mice, mice treated with QU-LG showed a statistically significant reduction in dermatopathologic symptoms. The results suggested that QU-LG had good antioxidant activity in vivo and in vitro and could be used for the prevention and treatment of cutaneous eczema.

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Quercetin flavonoid and vitamin C recuperate kidney functions in potassium bromate-induced renal dysfunction in Wistar rats

Cited by 2 publications

References 28 publications

The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

The Effect of Quercetin on the Structural Organisation of the Testicular Interstitial Space in the Dyshormonal State Induced by Tryptorelin at Day 270 in the Experiment

Antioxidant Activity of Quercetin-Containing Liposomes-in-Gel and Its Effect on Prevention and Treatment of Cutaneous Eczema

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