Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease

Chakraborty, J.; Singh, R. P.; Dutta, Debashis; Naskar, Amit K.; Rajamma, Usha; Mohanakumar, Kochupurackal P.

doi:10.1111/cns.12189

Cited by 114 publications

(60 citation statements)

References 54 publications

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“…3 In addition, QUE acts as an anti-inflammatory factor (such as ICAM-1) and modulates CD11b + , which may have implications for strategies attenuating endothelial dysfunction. [30][31][32] In this study, QUE regulates endothelial expression of ICAM-1 and attenuates inflammatory cell infiltration (CD11b + ), and ameliorates glucose metabolism and lipid metabolism disorder in DN. As is well known, the in vivo solubility of QUE is very low and circulation time is extremely short.…”

mentioning

confidence: 71%

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Tong¹,

Liu²,

Yan³

et al. 2017

IJN

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The purpose of the study was to reveal the therapeutic effect of quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating the expression of intercellular adhesion molecular-1 (ICAM-1) on endothelium as compared to free QUE. QUE 10 mg/kg as a single abdominal subcutaneous injection daily for 8 weeks continuously in diabetic rats and 10 mg/kg QUE nanoparticle complex as a single abdominal subcutaneous injection every 5 days, continuously administered for 8 weeks to diabetic rats. Blood and left kidneys were collected; pathological change of kidney, renal function, oxidative stress level, blood glucose level, serum lipid, urine protein, and albumin/creatinine ratio were measured; and neutrophil adhesion, ICAM-1 expression, and CD11b + cells infiltration were observed. Both QUE and QUE nanoparticle complex preconditioning ameliorated the pathological damage of kidney and improved renal function, alleviated renal oxidative stress injury, restricted inflammatory cells infiltration, and downregulated the ICAM-1 expression as compared to DN group, while QUE nanoparticle complex significantly alleviated this effect.

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mentioning

confidence: 71%

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Tong¹,

Liu²,

Yan³

et al. 2017

IJN

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“…42,43 A higher dose of the toxins might have elicited inflammatory responses beyond physiological control caused by microglial activation, 44 which in turn can lead to cell death, and was also demonstrated in our previous reports. 32,37 Because hypoxia, inflammatory trauma, and excitotoxic events could be the striatal environment of the lesioned side, 32,34,39,45 we suppose that the higher the dose of neurotoxin, the more hostile will be the condition for survival of the transplanted cells. Some studies suggest that ectopic placement of the graft, i.e., the striatum instead of SN, may be an issue that affects the survival of the grafts, the reason being the lack of trophic factors required for survival and maintenance of dopaminergic neurons.…”

Section: Discussionmentioning

confidence: 99%

“…32,34 Animals were anesthetized on the 50 th day after toxin infusion, perfused transcardially with 0.1 M phosphate-buffered saline (PBS; pH 7.4) initially, followed by 4% paraformaldehyde perfusion. The brain was dissected out, kept in the fixative overnight, and transferred to 30% sucrose solution.…”

Section: Tyrosine Hydroxylase Immunohistochemistrymentioning

confidence: 99%

“…The sections were mounted in DPX Mountant, following dehydration with graded alcohol and clearing in xylene. 32,34 The anti-rabbit IgG antibody-Alexa Flour 564-tagged sections were mounted on slides with Antifade (UltraCruz TM , sc-359850, Santa Cruz/ProLong Gold antifade, Invitrogen) mounting medium and viewed in an epifluorescence inverted microscope (Karl Ziess, Germany).…”

Section: Tyrosine Hydroxylase Immunohistochemistrymentioning

confidence: 99%

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Embryonic Stem Cells Derived Neuron Transplantation Recovery in Models of Parkinsonism in Relation to Severity of the Disorder in Rats

Haobam

Tripathy

Kaidery

et al. 2015

Rejuvenation Research

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Abstract6-Hydroxydopamine (6-OHDA)-and 1-methyl-4-phenylpyridinium (MPP + )-induced hemi-parkinsonism was investigated in relation to the severity of the disorder in terms of behavioral disability and nigral neuronal loss and recovery regarding the number of stem cell-derived neurons transplanted in the striatum. Intramedian forebrain bundle infusion of the parkinsonian neurotoxins and intra-striatal transplantation of differentiated embryonic stem cells (ESCs) were carried out by rat brain stereotaxic surgery. The severity of the disease was determined using the number of amphetamine-or apomorphine-induced rotations, striatal dopamine levels as estimated by high-performance liquid chromatography (HPLC)-electrochemistry, and the number of surviving tyrosine hydroxylase immunoreactive dopaminergic neurons in the substantia nigra pars compacta. Rats that received unilateral infusion of 6-OHDA or MPP + responded with dose-dependent, unilateral bias in turning behavior when amphetamine or apomorphine was administered. Rotational asymmetry in both models correlated significantly well with the loss in the number of nigral dopaminergic neurons and striatal dopamine depletion. Transplantation of 2 · 10 5 differentiated murine ESCs revealed remarkably similar kinds of recovery in both animal models. The survival of the grafted dopaminergic cells in the striatum was better in animals with low-severity parkinsonism, but poor in the animals with severe parkinsonism. Amphetamine-induced rotational recovery correlated positively with an increasing number of cells transplanted in animals with uniform nigral neuronal lesion. These results suggest that disease severity is an important factor for determining the number of cells to be transplanted in parkinsonian rats for desirable recovery, which may be true in clinical conditions too.

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“…The review revises all these aspects with the objective to generate debate among scientists. In this review, we emphasize the protective and preventive functions of apigenin and quercetin in neurodegenerative diseases by modulation of neurosignaling pathways 11,12 . 13,14 .…”

Section: Introductionmentioning

confidence: 99%

Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease

Jangdey

Gupta

Sarwa³

2018

PBJ

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Alzheimer's disease (AD) is an accelerating neurodegenerative disorder, dementia in the world. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmission & leading to neuronal dysfunction and loss in the brain. Flavonoid bioactive compounds are the major role for the designer of a new generation of therapeutic agents that are clinically effective in treating neurodegenerative diseases. Apigenin & quercetin are attractive biomarkers in this regards which has been epidemiological studies height a Neuroprotective and related to a lower risk of developing dementia or gradual decline its progressive. The continuing investigation of the potential preventive activity of quercetin and apigenin should be evaluated in long-term exposure clinical trials, using preparations with high bioavailability and promising to yield a possible remedy for this pervasive disease. Thus, the aim of the review, we analyzed the enhancing effects of apigenin and quercetin and discuss the potential of these compounds for Alzheimer's disease prevention and treatment.

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Quercetin Improves Behavioral Deficiencies, Restores Astrocytes and Microglia, and Reduces Serotonin Metabolism in 3‐Nitropropionic Acid‐Induced Rat Model of Huntington's Disease

Abstract: These results taken together suggest that quercetin could be of potential use not only for correcting movement disturbances and anxiety in HD, but also for addressing inflammatory damages.

Cited by 114 publications

References 54 publications

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Quercetin nanoparticle complex attenuated diabetic nephropathy via regulating the expression level of ICAM-1 on endothelium

Embryonic Stem Cells Derived Neuron Transplantation Recovery in Models of Parkinsonism in Relation to Severity of the Disorder in Rats

Apigenin and Quercetin: Potential Therapeutic Challenging Effective Against in Alzheimer’s Disease

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