Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells

Tao, Sifeng; He, Haifei; Chen, Qiang

doi:10.1007/s11010-014-2317-7

Cited by 149 publications

(90 citation statements)

References 42 publications

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“…These results are with the trend of studies indicating that some microRNAs, including the miR-145, are downregulated in ovarian cancer [65,66], and that cancer cells growth inhibition caused by quercetin may be correlated with the modulation of several miRs expression of [60,63,67,68].…”

Section: Chemoprotective Activities In Ovarian Cancer Cells Of Quercesupporting

confidence: 86%

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Kujawski¹,

Baraniak²,

Ożarowski³

et al. 2017

Altern Integr Med

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Despite the increasing number of studies on the molecular actions of quercetin and curcumin, their anticancer efficacy, safety and molecular aspects of chemopreventive action in the ovarian cancer prophylaxis or treatment and also their potential in the sensitization to cytostatics used in the clinical practice remains still not clearly understood.Based on basic studies we have summarized evidences for inhibitory activities of several often studied plantorigin bio-active compounds (mostly quercetin and curcumin) against ovarian cancer cells proliferation, their mechanisms of action as well as their strong potential to sensitization of ovarian cancer cells to the presence of several platinum-based cytostatics -cisplatin and oxaliplatin. Up to date only several dietary, clinical (cohort and case-control) studies evaluating the association of some flavonoids (mostly nonisoflavones) and its subgroup components consumption and ovarian cancer risk were already performed. According to the researchers, there has been no association between ovarian cancer risk and total nonisoflavone flavonoids intake. There is a still an insufficient amount of data designed to explain the effect of quercetin or curcumin (alone or together) on ovarian cancer development and/or its chemotherapy. Obtained results provide limited support for an association between nonisoflavone flavonoids intake and ovarian cancer risk, therefore there is a need for further and more accurate studies to be confirmed. We are of the opinion that this paper will contribute to a better understanding of the molecular basis for positive interactions between concomitant usage of quercetin or curcumin with above-mentioned cytostatics and other bio-active agents. This work may also contribute to an increase in the number of preclinical studies or other clinical, dietary trials using these or other phenolic / alkaloid, plant-origin constituents in order to investigate efficiency and safety of pharmacotherapy of ovarian cancer patients.

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Section: Chemoprotective Activities In Ovarian Cancer Cells Of Quercesupporting

confidence: 86%

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Kujawski¹,

Baraniak²,

Ożarowski³

et al. 2017

Altern Integr Med

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“…Liang et al identified that quercetin can induce autophagy in bladder cancer BIU-87 cell and in early stage, autophagy induced by quercetin can protect BIU-87 cells, and delay apoptosis [9]. Quercetin was used to inhibit proteasome activity of breast cancer cells MCF-7, and verified intracellular proteasome was involved in quercetin-induced autophagy [10]. As for HeLa cells, there was few report to identify the role of quercetin in autophagy.…”

Section: Discussionmentioning

confidence: 99%

The critical role of quercetin in autophagy and apoptosis in HeLa cells

Wang

Zhang

et al. 2015

Tumor Biol.

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In recent years, the effects of quercetin on autophagy and apoptosis of cancer cells have been widely reported, while effects on HeLa cells are still unclear. Here, HeLa cells were subjected to quercetin treatment, and then proliferation, apoptosis, and autophagy were evaluated using MTT, flow cytometry, and MDC staining, respectively. The LC3-I/II, Beclin 1, active caspase-3, and S6K1 phosphorylation were detected using Western blot assay. The ultrastructure of HeLa was observed via transmission electron microscope (TEM). Our findings showed that quercetin can dose-dependently inhibit the growth of HeLa cells. The MDC fluorescence was enhanced with increased concentration of quercetin and hit a plateau at 50 μmol/l. Western blot assay revealed that LC3-I/II ratio, Beclin 1, and active caspase-3 protein were enforced in a dose-dependent method. However, the phosphorylation of S6K1 gradually decreased, concomitant with an increase of autophagy. In addition, TEM revealed that the number of autophagic vacuoles was peaked at 50 μmol/l of quercetin. Besides, interference of autophagy with 3-MA led to proliferation inhibition and increased apoptosis in HeLa cells, accompanied by the decreased LC3-I/II conversion and the increased active caspase-3. In conclusion, quercetin can inhibit HeLa cell proliferation and induce protective autophagy at low concentrations; thus, 3-MA plus quercetin would suppress autophagy and effectively increased apoptosis.

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“…Quercetin shows significant inhibition effects on malignant cells growth in leukemia, breast, hepatic, ovarian, colorectal, gastric, and endometrial cancers [2–4]. Several studies have shown that quercetin controls cancer cell growth through the regulation of specific signaling pathways, such as decreasing oncogene expression, inducing malignant cells apoptosis and inhibiting angiogenesis, etc.…”

Section: Introductionmentioning

confidence: 99%

Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo

Zhou

Liao

et al. 2017

PLoS ONE

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Quercetin, a natural polyphenolic flavonoid compound, can inhibit the growth of several malignant cancers. However, the mechanism still remains unclear. Our previous findings have suggested that quercetin can significantly inhibit HepG2 cell proliferation and induce cell apoptosis in vitro. It can also affect cell cycle distribution and significantly decrease cyclin D1 expression. In this study, we investigated the anti-cancer effect of quercetin on HepG2 tumor-bearing nude mice and its effect on cyclin D1 expression in the tumor tissue. First, the nude murine tumor model was established by subcutaneous inoculation of HepG2 cells, then quercetin was administered intraperitoneally, and the mice injected with saline solution were used as controls. The daily behavior of the tumor-bearing mice was observed and differences in tumor growth and survival rate were monitored. The expression of cyclin D1 in isolated tumor sections was evaluated by immunohistochemistry. We found that HepG2 tumor became palpable in the mice one-week post-inoculation. Tumors in the control group grew rapidly and the daily behavior of the mice changed significantly, including listlessness, poor feeding and ataxia. The mice in quercetin-treated group showed delayed tumor growth, no significant changes in daily behavior, and the survival rate was significantly improved. Finally, we observed increased tumor necrosis and a lighter cyclin D1 staining with reduced staining areas. Our findings thus suggest that quercetin can significantly inhibit HepG2 cell proliferation, and this effect may be achieved through the regulation of cyclin D1 expression.

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Quercetin inhibits proliferation and invasion acts by up-regulating miR-146a in human breast cancer cells

Cited by 149 publications

References 42 publications

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

The critical role of quercetin in autophagy and apoptosis in HeLa cells

Investigation of the anti-cancer effect of quercetin on HepG2 cells in vivo

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