Quercetin mitigates memory deficits in scopolamine mice model via protection against neuroinflammation and neurodegeneration

Olayinka, Juliet N; Eduviere, Anthony T.; Adeoluwa, Olusegun; Fafure, Adedamola Adediran; Adebanjo, Adeshina Samuel; Ozolua, Raymond I.

doi:10.1016/j.lfs.2022.120326

Cited by 25 publications

(11 citation statements)

References 42 publications

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“…In relation to melatonin, it has been evaluated in clinical assays related to cranial nerve diseases, multiple sclerosis, epilepsy, sleep disorders, spinal cord injuries, migraine, trauma brain injury, dementia, Huntington, Alzheimer and Parkinson Diseases [ 162 , 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 , 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 , 185 , 186 , 187 , 188 , 189 , 190 , 191 , 192 , 193 , 194 ]. Of note, some of these diseases have also been studied in experimental models, evaluating the neuroprotective effect of these compounds mainly by their antioxidant and anti-inflammatory properties [ 195 , 196 , 197 , 198 , 199 , 200 , 201 , 202 , 203 , 204 , 205 ]. Moreover, the effects of quercetin, melatonin and curcumin have been explored in obese patients in different studies, but they have not proposed gliosis as an important comorbidity [ 2...…”

Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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Obesity remains a global health problem. Chronic low-grade inflammation in this pathology has been related to comorbidities such as cognitive alterations that, in the long term, can lead to neurodegenerative diseases. Neuroinflammation or gliosis in patients with obesity and type 2 diabetes mellitus has been related to the effect of adipokines, high lipid levels and glucose, which increase the production of free radicals. Cerebral gliosis can be a risk factor for developing neurodegenerative diseases, and antioxidants could be an alternative for the prevention and treatment of neural comorbidities in obese patients. Aim: Identify the immunological and oxidative stress mechanisms that produce gliosis in patients with obesity and propose antioxidants as an alternative to reducing neuroinflammation. Method: Advanced searches were performed in scientific databases: PubMed, ProQuest, EBSCO, and the Science Citation index for research on the physiopathology of gliosis in obese patients and for the possible role of antioxidants in its management. Conclusion: Patients with obesity can develop neuroinflammation, conditioned by various adipokines, excess lipids and glucose, which results in an increase in free radicals that must be neutralized with antioxidants to reduce gliosis and the risk of long-term neurodegeneration.

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Section: Protective Role Of Antioxidants In Gliosismentioning

confidence: 99%

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

et al. 2022

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“…They can work within the processes associated with AD ( Kaur et al, 2022 ; Maccioni et al, 2022 ). For example, quercetin belonging to the subcategory of flavonoids can significantly mitigate memory deficits in scopolamine mice model via protection against neuroinflammation and neurodegeneration ( Olayinka et al, 2022 ). Eriodictyol which is a natural flavonoid compound can ameliorate cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis ( Li L. et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer’s Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter

Sun

Zhang

et al. 2022

Front. Mol. Neurosci.

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Alzheimer’s disease (AD) is the most prevalent neural disorder. However, the therapeutic agents for AD are limited. Eucommia ulmoides Olive (EUO) is widely used as a traditional Chinese herb to treat various neurodegenerative disorders. Therefore, we investigated whether the extracts of EUO male flower (EUMF) have therapeutic effects against AD. We focused on the flavonoids of EUMF and identified the composition using a targeted HPLC-MS analysis. As a result, 125 flavonoids and flavanols, 32 flavanones, 22 isoflavonoids, 11 chalcones and dihydrochalcones, and 17 anthocyanins were identified. Then, the anti-AD effects of the EUMF were tested by using zebrafish AD model. The behavioral changes were detected by automated video-tracking system. Aβ deposition was assayed by thioflavin S staining. Ache activity and cell apoptosis in zebrafish were tested by, Acetylcholine Assay Kit and TUNEL assay, respectively. The results showed that EUMF significantly rescued the dyskinesia of zebrafish and inhibited Aβ deposition, Ache activity, and occurrence of cell apoptosis in the head of zebrafish induced by AlCl3. We also investigated the mechanism underlying anti-AD effects of EUMF by RT-qPCR and found that EUMF ameliorated AD-like symptoms possibly through inhibiting excessive autophagy and the abnormal expressions of ache and slc6a3 genes. In summary, our findings suggested EUMF can be a therapeutic candidate for AD treatment.

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“…Scopolamine is a competitive blocker of M-type acetylcholine receptors, which can lead to cholinergic dysfunction (Lei and Xiaoli, 2020), oxidative damage (Baek et al, 2020), mitochondrial dysfunction (Yamagami et al, 2021), apoptosis (Fronza et al, 2020), neuroinflammation (Olayinka et al, 2022), suppression of trophic factors (Yamagami et al, 2021), leading to severe impairment of learning and memory (Tang, 2019). In the present study, mice injected intraperitoneally with scopolamine showed prominent impairments in learning and memory skills as well as in the cholinergic system, oxidative stress and neuroinflammation of the brain tissues, which proved that the scopolamine-induced mouse model was a good choice for AD study.…”

Section: Discussionmentioning

confidence: 99%

Integrating network pharmacology analysis and pharmacodynamic evaluation for exploring the active components and molecular mechanism of moutan seed coat extract to improve cognitive impairment

Wang

Yang

et al. 2022

Front. Pharmacol.

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Paeonia suffruticosa (Moutan) is a traditional medicinal plant in China. Its seed coat is rich in resveratrol oligomer, especially suffruticosol B (SB). Previous studies had shown that the seed coat extracts of Paeonia suffruticosa (PSCE) had good cholinesterase inhibitory activity and neuroprotective effect, but the effective dose range was unknown, and the pharmacodynamic components and molecular mechanism of PSCE had not been discussed. The current study aimed to screen the pharmacodynamic components in PSCE and investigate the improvement effect of PSCE and the selected SB on scopolamine-induced cognitive dysfunction in mice and its mechanism. The results of high-throughput sequencing and bioinformatics analysis showed that suffruticosol B (SB) and trans-gnetin H (GH) might be the main active components of PSCE; PSCE might improve cognitive dysfunction through p53, HIF-1, MAPK, and PI3K-Akt signaling pathways, while SB and GH might improve cognitive dysfunction through HIF-1 signaling pathway. SB and GH had good molecular docking activity with the target of HIF-1 signaling pathway. The pharmacodynamic activities of PSCE and SB were further verified by behavioral experiments. PSCE and SB could improve the recognition ability of familiar and new objects and shorten the escape latency in the Morris Water Maze test (PSCE 120 mg∙kg-1, p < 0.05; SB 60 mg∙kg-1, p < 0.01); PSCE and SB could increase Ach and GSH levels, enhance the activities of ChAT, SOD and CAT, decrease the levels of IL-1β, IL-6, and TNF-α, and decrease the activity of AChE. In conclusion, the results indicated that PSCE might exert pharmacodynamic activity through multiple components, targets, and pathways, and SB and GH might be the main active components of PSCE. PSCE and SB might improve cognitive dysfunction by regulating cholinergic, antioxidant, and anti-inflammatory effects. These results indicated that PSCE and SB might be potential anti-AD drug candidates, providing a scientific basis for the development and utilization of Moutan bark.

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Quercetin mitigates memory deficits in scopolamine mice model via protection against neuroinflammation and neurodegeneration

Cited by 25 publications

References 42 publications

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Trends in Gliosis in Obesity, and the Role of Antioxidants as a Therapeutic Alternative

Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer’s Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter

Integrating network pharmacology analysis and pharmacodynamic evaluation for exploring the active components and molecular mechanism of moutan seed coat extract to improve cognitive impairment

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