Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats

Elshikh, Mohamed S.; Mohamed, Mohamed Othman; Darweesh, Mohamed Faisal; Hussein, Dina S.; Almutairi, Saeedah Musaed; Embaby, Azza

doi:10.1016/j.jksus.2022.101946

Cited by 9 publications

(6 citation statements)

References 45 publications

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“…A long-term high-fat diet can induce obesity and promote lipid accumulation in the liver and kidneys [ 28 , 45 , 46 ] while increasing the size of fat cells in adipose tissue and the corresponding organ weight [ 47 ]. In addition, the weight of the adipose tissue around the perirenal and epididymal of the animal accounted for a certain percentage of the total adipose tissue weight [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

“…The liver tissues were fixed in 10% formaldehyde, embedded in paraffin, and sliced to determine the morphology by hematoxylin and eosin (H&E) staining. The liver index, kidney index, and adipose fat index were calculated [ 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

“…At the end of the modeling, the average body weight of the HC group mice was >15% higher than that of the NC group mice, indicating the successful modeling of obese mice [44]. A long-term high-fat diet can induce obesity and promote lipid accumulation in the liver and kidneys [28,45,46] while increasing the size of fat cells in adipose tissue and the corresponding organ weight [47]. In addition, the weight of the adipose tissue around the perirenal and epididymal of the animal accounted for a certain percentage of the total adipose tissue weight [29].…”

Section: Gen Sd Supplementation To Reduce Obesitymentioning

confidence: 97%

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Solid Dispersions of Genistein via Solvent Rotary Evaporation for Improving Solubility, Bioavailability, and Amelioration Effect in HFD-Induced Obesity Mice

Qiu,

Zhang,

Fan

et al. 2024

Pharmaceutics

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Genistein (GEN) is an active pharmaceutical ingredient that presents the challenges of poor water solubility and low oral bioavailability. To tackle these challenges, a GEN solid dispersion was prepared by solvent rotary evaporation using polyvinylpyrrolidone K30 (PVP K30) as a carrier. The optimal formulation was determined by drug loading efficiency and in vitro release. The physical state of the solid dispersion was characterized by DSC, XRD, SEM and FT-IR. And the results of the in vitro release study indicate that the drug release of SD (1:7) increased 482-fold that of pure GEN at 60 min. Following oral administration to rats, the Cmax and AUC0–24 of SD (1:7) was increased 6.86- and 2.06-fold to that of pure GEN. The adipose fat index and body weight of the SD (1:7) group were significantly lower than those of the GEN group (p < 0.05). Meanwhile, the levels of TC and TG in the serum were significantly decreased in the SD (1:7) group compared with the GEN group (p < 0.05). All experiments revealed that solid dispersion could be a promising formulation approach to improve the dissolution rate, oral bioavailability, and effect on the reduction of lipid accumulation in high-fat diet-induced obesity mice.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Gen Sd Supplementation To Reduce Obesitymentioning

confidence: 97%

See 1 more Smart Citation

Solid Dispersions of Genistein via Solvent Rotary Evaporation for Improving Solubility, Bioavailability, and Amelioration Effect in HFD-Induced Obesity Mice

Qiu,

Zhang,

Fan

et al. 2024

Pharmaceutics

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“…In experiments related to the kidneys, a high-fat diet induced kidney inflammation by damaging small vascular tissues [ 83 , 84 ]. Palm oil and LO induce basal blood pressure and vascular wall inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…SIO is beneficial for lipid metabolism in tissues; it can reduce the likelihood of excessive fat accumulation and inflammation, especially in liver tissue, which is a key factor in the development of fatty liver. Furthermore, it plays a vital role in preventing the formation of free radicals and in promoting and maintaining balance in the immune system [ 83 , 84 , 85 ].…”

Section: Discussionmentioning

confidence: 99%

Cold-Pressed Sacha Inchi Oil: High in Omega-3 and Prevents Fat Accumulation in the Liver

Samrit,

Osotprasit,

Chaiwichien

et al. 2024

Pharmaceuticals

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The ability of oil supplementation to inhibit various metabolic syndromes has been recognized. However, there are currently no studies determining the effects of oil supplements on healthy conditions. Plukenetia volubilis L., also known as Sacha inchi, is a seed rich in essential unsaturated fatty acids that improves metabolic syndrome diseases, such as obesity and nonalcoholic fatty liver. However, the health benefits and effects of Sacha inchi oil (SIO) supplementation remain unclear. This study aims to evaluate the chemical effects and properties of Sacha inchi oil. The results of the chemical compound analysis showed that Sacha inchi is an abundant source of ω-3 fatty acids, with a content of 44.73%, and exhibits scavenging activity of 240.53 ± 11.74 and 272.41 ± 6.95 µg Trolox/g, determined via DPPH and ABTS assays, respectively, while both olive and lard oils exhibited lower scavenging activities compared with Sacha inchi. Regarding liver histology, rats given Sacha inchi supplements showed lower TG accumulation and fat droplet distribution in the liver than those given lard supplements, with fat areas of approximately 14.19 ± 6.49% and 8.15 ± 2.40%, respectively. In conclusion, our findings suggest that Sacha inchi oil is a plant source of ω-3 fatty acids and antioxidants and does not induce fatty liver and pathology in the kidney, pancreas, and spleen. Therefore, it has the potential to be used as a dietary supplement to improve metabolic syndrome diseases.

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Ascorbic acid alleviates oxidative stress and improves major salivary glands’ structure and function in diabetic rats: A histological and immunohistochemical study

Rasheed¹,

Embaby

Elkhamisy

et al. 2022

Journal of King Saud University - Science

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Quercetin mitigates the adverse effects of high fat diet on pancreatic and renal tissues in adult male albino rats

Cited by 9 publications

References 45 publications

Solid Dispersions of Genistein via Solvent Rotary Evaporation for Improving Solubility, Bioavailability, and Amelioration Effect in HFD-Induced Obesity Mice

Solid Dispersions of Genistein via Solvent Rotary Evaporation for Improving Solubility, Bioavailability, and Amelioration Effect in HFD-Induced Obesity Mice

Cold-Pressed Sacha Inchi Oil: High in Omega-3 and Prevents Fat Accumulation in the Liver

Ascorbic acid alleviates oxidative stress and improves major salivary glands’ structure and function in diabetic rats: A histological and immunohistochemical study

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