Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Tian, Haijun; Lü, Xin; Shi, Jing; Liu, Xiao Qi; Chen, Qu Bo; Wang, Qi; Chen, Yun Bo; Zhang, Shi Jie

doi:10.1111/jcmm.15026

Cited by 80 publications

(36 citation statements)

References 73 publications

(155 reference statements)

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“…Interestingly, the quercetin was able to increase the expression of SIRT1 and decrease the expression of NLRP3 inflammasome components such as NLRP3 and adapter protein ASC and activated caspase-1. The quercetin also decreased the expression of proinflammatory cytokines, such as IL-1β and IL-18 [31]. The findings of this study are extremely important because SIRT1 is a pivotal factor.…”

Section: Effect Of Quercetin On Sirt1 As Anti-inflammatory Factor and Nlrp3 Inflammasome Inhibitorsupporting

confidence: 52%

Anti-inflammatory potential of Quercetin in COVID-19 treatment

2021

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SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Phylogenetic findings show more similarity of the SARS-CoV-2 virus with bat coronaviruses, and less with SARS-CoV. Quercetin is a carbohydrate-free flavonoid that is the most abundant flavonoid in vegetables and fruits and has been the most studied to determine the biological effects of flavonoids. Inflammasomes are cytosolic multi-protein complexes assembling in response to cytosolic PAMP and DAMPs, whose function is to generate active forms of cytokines IL-1β and IL-18. Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2. Quercetin suppresses the NLRP3 inflammasome by affecting these regulators. Quercetin, as an anti-inflammatory, antioxidant, analgesic and inflammatory compound, is probably a potential treatment for severe inflammation and one of the main life-threatening conditions in patients with COVID-19.

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Section: Effect Of Quercetin On Sirt1 As Anti-inflammatory Factor and Nlrp3 Inflammasome Inhibitorsupporting

confidence: 52%

Anti-inflammatory potential of Quercetin in COVID-19 treatment

2021

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“…It was also found that the activation of the NF-κB signaling pathway was not significantly influenced by the silencing of of NLRP3 in the TNF-α-induced inflammatory microenvironment. Studies have revealed that Quer can attenuate diabetic encephalopathy and protect against isoniazid-induced hepatotoxicity by suppressing the NLRP3 pathway ( 30 , 48 ). Likewise, the present study determined that Quer downregulated the expression of NLRP3 inflammasome-associated proteins and genes treated in the hPDLSCs stimulated with TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway

et al. 2021

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Quercetin (Quer) is a typical antioxidant flavonoid from plants that is involved in bone metabolism, as well as in the progression of inflammatory diseases. Elevated levels of tumor necrosis factor-α (TNF-α), a typical pro-inflammatory cytokine, can affect osteogenesis. In the present study, TNF-α was used to establish an in vitro model of periodontitis. The effects of Quer on, as well as its potential role in the osteogenic response of human periodontal ligament stem cells (hPDLSCs) under TNF-α-induced inflammatory conditions and the underlying mechanisms were then investigated. Within the appropriate concentration range, Quer did not exhibit any cytotoxicity. More importantly, Quer significantly attenuated the TNF-α induced the suppression of osteogenesis-related genes and proteins, alkaline phosphatase (ALP) activity and mineralized matrix in the hPDLSCs. These findings were associated with the fact that Quer inhibited the activation of the NF-κB signaling pathway, as well as the expression of NLRP3 inflammation-associated proteins in the inflammatory microenvironment. Moreover, the silencing of NLRP3 by small interfering RNA (siRNA) was found to protect the hPDLSCs against TNF-α-induced osteogenic damage, which was in accordance with the effects of Quer. On the whole, the present study demonstrates that Quer reduces the impaired osteogenesis of hPDLSCs under TNF-α-induced inflammatory conditions by inhibiting the NF-κB/NLRP3 inflammasome pathway. Thus, Quer may prove to be a potential remedy against periodontal bone defects.

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“…As noted above, the phenolic compound quercetin can inhibit NFκB and MMP9 activity [ 108 ]. It can also significantly decrease NLRP3 inflammasome formation [ 133 , 134 , 135 , 136 ]. Thus, quercetin from food and as a supplement may to protect BBB integrity and prevent the activation of DAM in ApoE4 carriers.…”

Section: Precision Nutrition Considerationsmentioning

confidence: 99%

Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers

et al. 2021

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The ApoE4 allele is the most well-studied genetic risk factor for Alzheimer’s disease, a condition that is increasing in prevalence and remains without a cure. Precision nutrition targeting metabolic pathways altered by ApoE4 provides a tool for the potential prevention of disease. However, no long-term human studies have been conducted to determine effective nutritional protocols for the prevention of Alzheimer’s disease in ApoE4 carriers. This may be because relatively little is yet known about the precise mechanisms by which the genetic variant confers an increased risk of dementia. Fortunately, recent research is beginning to shine a spotlight on these mechanisms. These new data open up the opportunity for speculation as to how carriers might ameliorate risk through lifestyle and nutrition. Herein, we review recent discoveries about how ApoE4 differentially impacts microglia and inflammatory pathways, astrocytes and lipid metabolism, pericytes and blood–brain barrier integrity, and insulin resistance and glucose metabolism. We use these data as a basis to speculate a precision nutrition approach for ApoE4 carriers, including a low-glycemic index diet with a ketogenic option, specific Mediterranean-style food choices, and a panel of seven nutritional supplements. Where possible, we integrate basic scientific mechanisms with human observational studies to create a more complete and convincing rationale for this precision nutrition approach. Until recent research discoveries can be translated into long-term human studies, a mechanism-informed practical clinical approach may be useful for clinicians and patients with ApoE4 to adopt a lifestyle and nutrition plan geared towards Alzheimer’s risk reduction.

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Quercetin protects against diabetic encephalopathy via SIRT1/NLRP3 pathway in db/db mice

Cited by 80 publications

References 73 publications

Anti-inflammatory potential of Quercetin in COVID-19 treatment

Anti-inflammatory potential of Quercetin in COVID-19 treatment

Quercetin reverses TNF‑α induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF‑κB/NLRP3 inflammasome pathway

Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers

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