Quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in rat model of cardiopulmonary resuscitation through modulating Bmi‑1 expression

Abstract

With extensive pharmacological actions, quercetin has anti‑oxidant, free radical scavenging, anti‑tumor, anti‑inflammatory, anti‑bacterial and anti‑viral activity. Quercetin also reduces blood glucose and reduces high blood pressure, and has immunoregulation and cardiovascular protection functions. Additionally, it has been reported that it can reduce depression. The current study evaluated whether quercetin protects against inflammation, matrix metalloproteinase‑2 (MMP‑2) activation and apoptosis induction in a rat model of cardiopulmonary resuscitation (CPR), and whether Bmi‑1 expression was involved in the effects. In CPR model rats, treatment with quercetin significantly recovered left ventricular ejection fraction, left ventricular fractional shortening, ejection fraction (%), and left ventricle weight/body weight. Treatment with quercetin significantly inhibited ROS generation, inflammation and MMP‑2 protein expression in the rat model CPR. Finally, quercetin significantly suppressed caspase‑3 activity and activated Bmi‑1 protein expression in the rat model of CPR. The results demonstrated that quercetin protects against inflammation, MMP‑2 activation and apoptosis induction in a rat model of CPR, and that this may be mediated by modulating Bmi‑1 expression.

Quercetin as a nephroprotector after warm ischemia: histomorphometric evaluation in a rodent model

“…Quercetin is a flavonoid that has proven to be effective in combating the production of reactive oxygen species and has positively modified the values of biochemical markers of homeostatic functions of organs and tissues (12)(13)(14)(15)(16)(17), including kidneys in different situations (11) such as warm ischemia (18)(19)(20). Our quantitative results corroborate that the use of quercetin is beneficial in warm renal ischemia.…”

“…Quercetin has shown positive results under different experimental conditions, mainly attributed to its antioxidant and anti-inflammatory properties (11)(12)(13)(14). This flavonoid has also been shown to be promising when associated with warm ischemia in different organs and tissues (15)(16)(17) and, more specifically, in the kidney (18)(19)(20).…”

Comparative Pharmacognosy, Chemical Profile and Antioxidant Activity of Extracts from Phania matricarioides (Spreng.) Griseb. Collected from Different Localities in Cuba

“…In particular, phenolic compounds have been shown to be effective agents in scavenging reactive species responsible for inducing oxidative stress. In concordance with chemical studies, quercetin was identified in the three extracts, which has been noted in the literature for its antioxidant activities [35,36], and anticancer [37], neuroprotection [38], hepatoprotection [39], anti-inflammatory [40], and antiparasitic [41,42] properties. Among the P. matricarioides extracts, higher antioxidant activity was observed in the PmC extract, which also displayed the higher concentration of quercetin according to the chemical profile as shown in the quantitative map.…”

The Gut Microbiota Links Dietary Polyphenols With Management of Psychiatric Mood Disorders

“…There is also ample evidence that quercetin can reduce neuroinflammation and as previously indicated, the urolithin metabolic products derived from quercetin have more bioactivity than quercetin itself. In a rat cardiopulmonary resuscitation model of depression, quercetin inhibited ROS generation, neuroinflammation and metalloproteinase-2 protein expression corresponding to recovering left ventricular ejection fraction reduced by the depression paradigm (Wang D. et al, 2018). Mice undergoing chronic unpredictable stress for 21 days were simultaneously treated with 30 mg/kg of quercetin, which alleviated both anxiety and depression behavioral dysfunctions.…”