Purpose: To quantitatively evaluate the possible long-term protective effects of quercetin during renal warm ischemia. Materials and Methods: Male rats were allocated into 4 groups: sham (S), sham quercetin (SQ), ischemia (I), and ischemia quercetin (IQ). Groups SQ and IQ received quercetin (50mg/kg) before and after surgery. Groups I and IQ had their left renal vessels clamped for 60 minutes. All animals were euthanized four weeks after the procedure, and serum urea and creatinine levels were measured. Renal weight and volume, cortex-non-cortex area ratio (C-NC), cortical volume (CV), glomerular volumetric density (Vv[glom]), volume-weighted glomerular volume (VWGV) and number of glomeruli per kidney (N[glom]) were evaluated by stereological methods. Results were considered statistically signifi cant when p <0.05. Results: Serum urea levels in group I increased by 10.4% in relation to group S, but no differences were observed among the other groups. The C-NC of group I was lower than those of all other groups, and group IQ had similar results to sham groups. The Vv [glom] and N[glom] of group I were lower than those of group S (33.7% and 28.3%, respectively) and group IQ had no signifi cant difference compared to the S group. Conclusions: Quercetin was effective as a nephroprotective agent in preventing the glomerular loss observed when the kidney was subjected to warm ischemia. This suggests that this fl avonoid may be used preventively in kidney surgery, when warm ischemia is necessary, such as partial nephrectomy.
Pensando a partir da crescente exposição de crianças na internet e, consequentemente, observando os perigos que esta superexposição pode trazer, o presente artigo busca analisar quais os limites existentes entre o direito dos pais e responsáveis de publicar sobre o seu dia a dia, do qual os filhos fazem parte, e a publicação desenfreada de crianças na internet, sobretudo nas redes sociais, violando os direitos personalíssimos do menor, e trazendo para debate o bem-estar destes que são a parte mais frágil da relação familiar. O debate acerca deste tema traz consigo uma grande relevância social, visto que apresenta e traz luz a diversos incômodos e situações que poderão ser enfrentadas pelo menor que tem a sua privacidade violada, analisando e compreendendo a criança como sujeito de direitos e não como uma posse dos pais.
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