Quercetin suppresses lung cancer growth by targeting Aurora B kinase

Zhu, Xingyu; Peijie, Ma; Peng, Dan; Youg, Wang; Wang, Daojun; Chen, Xinzheng; Zhang, Xijun; Song, Yangrong

doi:10.1002/cam4.891

Cited by 69 publications

(32 citation statements)

References 37 publications

(41 reference statements)

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“…For JB6 Cl41 cells and A549 lung cancer cells, researchers showed that quercetin inhibits aurora B activities and reduces the phosphorylation of histone 3 (Xingyu et al, ). Quercetin also reduces ROS production induced by exposure to hexavalent chromium [Cr(VI)] in BEAS‐2B cells.…”

Section: Anticancer Perspectives Of Quercetinmentioning

confidence: 99%

Anticancer potential of quercetin: A comprehensive review

Rauf

Imran

Khan

et al. 2018

Phytotherapy Research

501

276

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Diet plays a key role to maintaining healthy life. Many natural products present in our diet, such as flavonoids, can prevent the progression of cancer. Quercetin, a distinctive bioactive flavonoid, is a dietary component that has attracted the attention of dietitians and medicinal chemists due to its numerous health-promoting effects. It is an outstanding antioxidant that has a well-documented role in reducing different human cancers. Quercetin exhibits direct proapoptotic effects on tumor cells and thus can inhibit the progress of numerous human cancers. The anticancer effect of quercetin has been documented in numerous in vitro and in vivo studies that involved several cell lines and animal models. On the other hand, the high toxic effect of quercetin against cancer cells is accompanied with little or no side effects or harm to normal cells. Accordingly, this review presents an overview of recent developments on the use of quercetin against different types of cancer along with mechanisms of action. In addition, the present review summarizes the literature pertaining to quercetin as an anticancer agent and provides an assessment of the potential utilization of this natural compound as a complimentary or alternative medicine for preventing and treating cancer.

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Section: Anticancer Perspectives Of Quercetinmentioning

confidence: 99%

Anticancer potential of quercetin: A comprehensive review

Rauf

Imran

Khan

et al. 2018

Phytotherapy Research

501

276

View full text Add to dashboard Cite

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“…QR exhibits anticancer activity in lung cancer (A549 cells) by activation of the MEK–ERK pathway along with inactivation of Akt-1 and variation in expression of Bcl-2 family (proteins) 42. QR suppresses the growth of a variety of NSCLC cell lines by inhibiting overexpressed Aurora-B kinase and can be used for lung cancer therapy 43. However, the application of QR in lung cancer therapy has been restricted by a number of factors, ie, low water solubility (2.15 µg/mL), low bioavailability and rapid clearance from plasma 44,45.…”

Section: Introductionmentioning

confidence: 99%

<p>Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy</p>

Riaz

Zhang

Wong

et al. 2019

IJN

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Purpose: Lung cancer has a high incidence rate worldwide with a 5-year survival rate of 18%, and is the leading cause of cancer-related deaths. The aim of this study is to augment therapeutic efficacy of quercetin (QR) for lung cancer therapy by targeting transferrin receptors, which are overexpressed and confined to tumor cells. Methods: In this study, T7 surface-functionalized liposomes loaded with QR (T7-QR-lip) having different T7 peptide densities (0.5%, 1% and 2%) were prepared by the film hydration method. T7 surface-functionalized liposomes were characterized and evaluated in terms of in vitro cytotoxicity and cellular uptake, 3D tumor spheroid penetration and inhibition capabilities, in vivo biodistribution and therapeutic efficacy in mice with orthotopic lung-tumor implantation by fluorescent and bioluminescent imaging via pulmonary administration. Results: In vitro, 2% T7-QR-lip exhibited significantly augmented cytotoxicity (~3-fold), higher apoptosis induction and S-phase cell-cycle arrest. A prominent peak right-shift and enhanced mean fluorescence intensity was observed in A549 cells treated with T7 Coumarin-6 liposomes (T7-Cou6-lip), confirming the target specificity of T7 targeted liposomes; while, after treatment with T7-QR-lip and non-targeted QR-lip, no significant difference was observed in cellular uptake and in vitro cytotoxicity studies in MRC-5 (normal lung fibroblast) cells. T7-Cou6-lip showed higher fluorescence intensity in A549 cells and a significantly deeper penetration depth of 120 µm in the core of the tumor spheroids and T7-QR-lip produced significantly higher tumor-spheroid growth inhibition. The in vivo biodistribution study via pulmonary delivery of T7 1,1’-dioctadecyltetramethyl-indotricarbocyanine iodide liposomes demonstrated liposome accumulation in the lungs and sustained-release behavior up to 96 h. Further, T7-QR-lip significantly enhanced the anticancer activity of QR and lifespan of mice ( p <0.01, compared with saline) in orthotopic lung tumor-bearing mice via pulmonary administration. Conclusion: T7 surface-functionalized liposomes provide a potential drug delivery system for a range of anticancer drugs to enhance their therapeutic efficacy by localized (pulmonary) administration and targeted delivery.

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“…In general, when used alone, pure phenolic compounds have been effective in decreasing cell viability or activating cell death at micromolar concentrations. This has been shown, for example, for apigenin and curcumin in SH-SY5Y neuroblastoma cells [1,18,19] or naringenin and quercetin in A549 small lung cancer cells [20,21]. Therefore, we propose that the effects of JE were due to the potentiation, synergy, or both between several plant polyphenols through common or different mechanisms.…”

Section: Discussionmentioning

confidence: 64%

The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways

Raasmaja

Stenius

Ghalali

2019

IJMS

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Juniper (Juniperus communis L.) is a northern coniferous plant generally used as a spice and for nutritional purposes in foods and drinks. It was previously reported that juniper extract (JE) affects p53 activity, cellular stress, and gene expression induced cell death in human neuroblastoma cells. Therefore, the effects of juniper on p53 and Akt signaling was examined further in A549 lung, 22RV1 and DU145 prostate, and HepG2 liver cancer cells using Western blot, confocal microscopy, and MTT analysis. We found that juniper simultaneously decreased cell viability, activated the p53 pathway, and inactivated the PI3K/Akt pathway. The p53 activation was associated with increased nuclear p53 level. Akt was dephosphorylated, and its inactivation was associated with increased levels of PHLPP1 and PHLPP2 phosphatases. Parallel increases of PARP suggest that JE decreased cell viability by activating cell death. In addition, JE potentiated the effects of gemcitabine and 5-fluorouracil anticancer drugs. Thus, JE can activate cell death in different cancer cell lines through p53 and Akt pathways.

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Quercetin suppresses lung cancer growth by targeting Aurora B kinase

Cited by 69 publications

References 37 publications

Anticancer potential of quercetin: A comprehensive review

Anticancer potential of quercetin: A comprehensive review

<p>Pulmonary delivery of transferrin receptors targeting peptide surface-functionalized liposomes augments the chemotherapeutic effect of quercetin in lung cancer therapy</p>

The Water Extract of Juniperus communis L. Induces Cell Death and Sensitizes Cancer Cells to Cytostatic Drugs through p53 and PI3K/Akt Pathways

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