Quercetine protects liver from oxidative stress induced by glycerole

Cvetković, Tatjana; Vlahović, Predrag; Savic, V.; Pavlović, Dušica; Kocić, Gordana; Djordjević, Vidosava

doi:10.1016/s0168-8278(00)81147-2

Cited by 2 publications

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“…The initial screening was performed with resveratrol and quercetin as target compounds with powerful anti-oxidant and anti-inflammatory properties but a very low solubility in water. [33][34][35] As expected only traces of resveratrol or quercetin could be dissolved in the cosolvent-free system. The addition of 20% ILs resulted in a remarkable increase in solubility, without affecting the ability to dissolve 1 M sucrose.…”

Section: Solubility Of Acceptors In Il Cosolvent Systemssupporting

confidence: 71%

Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability

et al. 2013

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Over the past decade, disaccharide phosphorylases have received increasing attention as promising biocatalysts for glycoside synthesis. Unfortunately, these enzymes typically have a very low affinity for non-carbohydrate acceptors, which urges the addition of cosolvents to increase the dissolved concentration of these acceptors. However, commonly applied solvents such as methanol and dimethyl sulfoxide (DMSO) are not compatible with many intended applications of carbohydrate-derived products. In this work, the solubility of a wide range of relevant acceptors was assessed in the presence of ionic liquids (ILs) as alternative and 'green' solvents. The IL AMMOENG 101 was found to be the most effective co-solvent for compounds as diverse as medium-and long-chain alcohols, flavonoids, alkaloids, phenolics and terpenes. Moreover, this IL was shown to be less deleterious to the stability and activity of sucrose phosphorylase than the commonly used dimethyl sulfoxide. To demonstrate the usefulness of this solvent system, a process for the resveratrol glycosylation was established in a buffer containing 20% AMMOENG 101, 1 M sucrose and saturated amounts of the acceptor. A single regioisomer 3-O-alpha-D-glucopyranosyl-(E)-resveratrol was obtained as proven by NMR spectroscopy

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Section: Solubility Of Acceptors In Il Cosolvent Systemssupporting

confidence: 71%

Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability

et al. 2013

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“…The most probable mechanisms of lipid peroxidation inhibition by quercetin are: halation of iron, scavenging of free radicals with the formation of less effective radicals, or the increase of GSH content in the liver. [14,19,20] The obtained results show that liver arginase activity is elevated in glycerolinduced acute renal failure. Considering that the level of hepatic urea synthesis is dependent of the availability of substrates, increased arginase activity occurs as a consequence of accelerated protein breakdown.…”

Section: Discussionmentioning

confidence: 54%

Role of Quercetin on Hepatic Urea Production in Acute Renal Failure

2003

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Acute renal failure (ARF) is a serious damage of renal function induced by various nephrotoxic drugs, ischemia, bilateral urethral obstruction, trauma and unilateral nephrectomy. Dramatic clinical syndrome, azotemia, develops as a result of hypovolemia, oliguria, reduced glomerular filtration and acidosis. In addition to classic medications recent studies give more attention to beneficial effect of natural plant products as bioflavonoids. We have studied the influence of bioflavonoid, quercetin, on hepatic urea production in glycerol induced ARF in the rats. Male Sprague Dawley rats were used in the experiment. The value of urea production in the liver was determined by measuring of liver arginase activity, the terminal enzyme of urea cycle. Arginase activity was increased (p < 0.01) as well as urea level (p < 0.001) 48 h after glycerol administration. Pretreatment by quercetin suppressed the arginase activity in the liver (p < 0.05) and plasma levels of urea (p < 0.01). So, we have concluded that quercetin may be beneficial in glycerol induced ARF.

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Quercetine protects liver from oxidative stress induced by glycerole

Cited by 2 publications

References 0 publications

Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability

Ionic liquids as cosolvents for glycosylation by sucrose phosphorylase: balancing acceptor solubility and enzyme stability

Role of Quercetin on Hepatic Urea Production in Acute Renal Failure

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