Quinazolines and 1,4-Benzodiazepines. XVIII.¹ The Acetylation of Chlordiazepoxide² and Its Transformation into 6-Chloro-4-phenyl-2-quinazolinecarboxaldehyde³

Abstract

Quinazolines and 1,4-Benzodiazepines. XVIII.1 The Acetylation of Chlordiazepoxide2and Its Transformation into 6-Chloro-4-phenyl-2-quinazolinecarboxaldeliyde3

Rapid determination of eight benzodiazepines in suspected counterfeit pharmaceuticals using surface‐enhanced Raman scattering with handheld Raman spectrometers

“…MeOH and undergo hydrolysis [42][43][44][45] in acidic or basic medium thus making the API extraction problematic using either approach described in this study. Additionally, the triazolam tablets were colored and the resultant extract had a blue color which may have resulted in interfering luminescence masking the Raman spectral features of the analyte.…”

Structure of 7-chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepin-3-ol

“…Introduction. The crystal structure of the title compound (Sternbach, Reeder, Stempel & Rachlin, 1964) has been determined as part of an investigation of structure-activity relationships for 1,4-benzodiazepine derivatives. Certain of these compounds exhibit marked anxiolytic and anti-convulsant activity in man (Randall, Schallek, Sternbach & Ning, 1974).…”

Studies on Benzodiazepinooxazoles. III. Reactions and Rearrangements of Benzo [6, 7]-1, 4-diazepino-[5, 4-<I>b</I>] oxazole Derivatives

“…Bromo -2,3,5, 6, 7,11 b-hexahydro -5-methylene -7-methyl -11b-phenylbenzo [6,7] -1,4-diazepino[5,[4][5][6][7][8][9][10]]oxazol-6-one (Vb)-The reaction of 10-bromo-2,3,5,6,7,11b-hexahydro-7-methyl-11b-phenylbenzo[6,7]-1,4-diazepino[5,4-b]-oxazol-6-one (IIIb) (3.73 g) and NaH (0.48 g) in 40 ml of DMF afforded Vb (1.54 g) J=1.2 Hz, >C=CH2) 4.22 (2H, multiplet, -CH2 -O-), 7.3 (center, 8H, multiplet, aromatic protons). Anal.…”